Detalhe da pesquisa
1.
SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression.
Nucleic Acids Res
; 51(1): 144-165, 2023 01 11.
Artigo
Inglês
| MEDLINE | ID: mdl-36546765
2.
An equine iPSC-based phenotypic screening platform identifies pro- and anti-viral molecules against West Nile virus.
Vet Res
; 55(1): 32, 2024 Mar 16.
Artigo
Inglês
| MEDLINE | ID: mdl-38493182
3.
SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction.
Nucleic Acids Res
; 49(13): 7695-7712, 2021 07 21.
Artigo
Inglês
| MEDLINE | ID: mdl-34232992
4.
Novel Antiviral Molecules against Ebola Virus Infection.
Int J Mol Sci
; 24(19)2023 Sep 30.
Artigo
Inglês
| MEDLINE | ID: mdl-37834238
5.
Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands.
Molecules
; 28(3)2023 Jan 24.
Artigo
Inglês
| MEDLINE | ID: mdl-36770826
6.
1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors.
Molecules
; 25(12)2020 Jun 17.
Artigo
Inglês
| MEDLINE | ID: mdl-32560578
7.
1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase.
J Enzyme Inhib Med Chem
; 34(1): 1730-1739, 2019 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-31822127
8.
A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism.
Antimicrob Agents Chemother
; 62(6)2018 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29632009
9.
Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response.
Antimicrob Agents Chemother
; 61(10)2017 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28807907
10.
Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin.
Antimicrob Agents Chemother
; 60(10): 5631-9, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27401578
11.
Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents.
Bioorg Med Chem
; 24(21): 5172-5182, 2016 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27614917
12.
Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 9): 1890-9, 2015 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-26327379
13.
The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components.
Antimicrob Agents Chemother
; 60(3): 1438-49, 2015 Dec 14.
Artigo
Inglês
| MEDLINE | ID: mdl-26666917
14.
Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity.
PLoS Pathog
; 9(10): e1003678, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-24098125
15.
[Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening]. / Activation de la réponse innée antivirale par des inhibiteurs de la biosynthèse des pyrimidines - Les surprises d'un criblage phénotypique.
Med Sci (Paris)
; 31(1): 98-104, 2015 Jan.
Artigo
Francês
| MEDLINE | ID: mdl-25658737
16.
A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis.
Front Pharmacol
; 15: 1329011, 2024.
Artigo
Inglês
| MEDLINE | ID: mdl-38444943
17.
Synergy of the antibiotic colistin with echinocandin antifungals in Candida species.
J Antimicrob Chemother
; 68(6): 1285-96, 2013 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-23378416
18.
Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors.
Bioorg Med Chem
; 21(1): 257-68, 2013 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23199481
19.
Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation.
Nucleic Acids Res
; 39(8): 3458-72, 2011 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-21149268
20.
Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli.
FEBS J
; 290(12): 3165-3184, 2023 06.
Artigo
Inglês
| MEDLINE | ID: mdl-36748301