1.
Biosci Biotechnol Biochem
; 79(1): 11-5, 2015.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25184606
RESUMO
The first synthesis of the racemate of terpendole E, a specific inhibitor of the mitotic kinesin Eg5, has been achieved from a known tricyclic dihydroxy ketone by a 13-step sequence that involves diastereoselective installation of its C3 quaternary stereocenter via a cyclopropyl ketone intermediate and Pd-mediated two-step construction of the indole ring moiety as the key transformations.