Detalhe da pesquisa
1.
Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors.
Proc Natl Acad Sci U S A
; 120(28): e2302485120, 2023 07 11.
Artigo
Inglês
| MEDLINE | ID: mdl-37399416
2.
Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket.
Proc Natl Acad Sci U S A
; 119(43): e2204481119, 2022 10 25.
Artigo
Inglês
| MEDLINE | ID: mdl-36252024
3.
Intersectin - many facets of a scaffold protein.
Biochem Soc Trans
; 52(1): 1-13, 2024 Feb 28.
Artigo
Inglês
| MEDLINE | ID: mdl-38174740
4.
Mutations in the α4-α5 allosteric lobe of RAS do not significantly impair RAS signaling or self-association.
J Biol Chem
; 298(12): 102661, 2022 12.
Artigo
Inglês
| MEDLINE | ID: mdl-36334633
5.
Direct inhibition of RAS: Quest for the Holy Grail?
Semin Cancer Biol
; 54: 138-148, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-29248537
6.
Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function.
Am J Physiol Cell Physiol
; 319(5): C933-C944, 2020 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32936699
7.
Inhibition of RAS: proven and potential vulnerabilities.
Biochem Soc Trans
; 48(5): 1831-1841, 2020 10 30.
Artigo
Inglês
| MEDLINE | ID: mdl-32869838
8.
Inhibition of RAS function through targeting an allosteric regulatory site.
Nat Chem Biol
; 13(1): 62-68, 2017 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-27820802
9.
Pharmacological targeting of RAS: Recent success with direct inhibitors.
Pharmacol Res
; 139: 503-511, 2019 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30366101
10.
Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus.
Arterioscler Thromb Vasc Biol
; 38(3): 529-541, 2018 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29301787
11.
Intersectin scaffold proteins and their role in cell signaling and endocytosis.
Biochim Biophys Acta Mol Cell Res
; 1864(1): 23-30, 2017 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-27746143
12.
Silencing Intersectin 1 Slows Orthotopic Neuroblastoma Growth in Mice.
J Pediatr Hematol Oncol
; 39(8): e413-e418, 2017 11.
Artigo
Inglês
| MEDLINE | ID: mdl-28787396
13.
Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity.
J Biol Chem
; 290(19): 12058-67, 2015 May 08.
Artigo
Inglês
| MEDLINE | ID: mdl-25802336
14.
Probing RAS Function Using Monobody and NanoBiT Technologies.
Methods Mol Biol
; 2797: 211-225, 2024.
Artigo
Inglês
| MEDLINE | ID: mdl-38570462
15.
HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer.
Cell Death Differ
; 2024 May 28.
Artigo
Inglês
| MEDLINE | ID: mdl-38802657
16.
Emerging roles for intersectin (ITSN) in regulating signaling and disease pathways.
Int J Mol Sci
; 14(4): 7829-52, 2013 Apr 10.
Artigo
Inglês
| MEDLINE | ID: mdl-23574942
17.
Secreted frizzled related-protein 2 is prognostic for human pancreatic cancer patient survival and is associated with fibrosis.
Cancer Biomark
; 38(3): 287-300, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37955079
18.
Targeting the "undruggable" RAS with biologics.
Adv Cancer Res
; 153: 237-266, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35101232
19.
Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants.
Cell Rep
; 38(6): 110322, 2022 02 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35139380
20.
Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis.
Small GTPases
; 13(1): 114-127, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33949915