Detalhe da pesquisa
1.
Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain.
Med Chem Res
; : 1-7, 2023 Jun 03.
Artigo
Inglês
| MEDLINE | ID: mdl-37362320
2.
Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.
J Pharmacol Exp Ther
; 358(1): 125-37, 2016 07.
Artigo
Inglês
| MEDLINE | ID: mdl-27189974
3.
Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage.
ACS Med Chem Lett
; 11(3): 266-271, 2020 Mar 12.
Artigo
Inglês
| MEDLINE | ID: mdl-32184955
4.
A simple strategy for mitigating the effect of data variability on the identification of active chemotypes from high-throughput screening data.
J Biomol Screen
; 12(2): 276-84, 2007 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-17272827
5.
2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor.
J Med Chem
; 49(23): 6819-32, 2006 Nov 16.
Artigo
Inglês
| MEDLINE | ID: mdl-17154512
6.
HTS quality control and data analysis: a process to maximize information from a high-throughput screen.
Comb Chem High Throughput Screen
; 8(6): 521-7, 2005 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-16178811
7.
Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.
Int J Alzheimers Dis
; 2014: 431858, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-25097793
8.
Acyl guanidine inhibitors of ß-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.
J Med Chem
; 55(21): 9208-23, 2012 Nov 08.
Artigo
Inglês
| MEDLINE | ID: mdl-23030502
9.
Natural products or not? How to screen for natural products in the emerging HTS paradigm.
Methods Mol Biol
; 190: 153-68, 2002.
Artigo
Inglês
| MEDLINE | ID: mdl-12029820
10.
2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors.
Bioorg Med Chem Lett
; 17(11): 3208-11, 2007 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17383874
11.
Amino-caprolactam derivatives as gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 17(21): 5790-5, 2007 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17869509
12.
Solid-phase synthesis and anti-infective activity of a combinatorial library based on the natural product anisomycin.
Bioorg Med Chem Lett
; 15(18): 4151-4, 2005 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16005213
13.
Targeting the MraY and MurG bacterial enzymes for antimicrobial therapeutic intervention.
Anal Biochem
; 314(2): 243-52, 2003 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-12654311