Detalhe da pesquisa
1.
Novel 1,4-Dihydropyridine Derivatives as Mineralocorticoid Receptor Antagonists.
Int J Mol Sci
; 24(3)2023 Jan 26.
Artigo
Inglês
| MEDLINE | ID: mdl-36768761
2.
Synthesis and biological activity of cyclopropyl Δ7-dafachronic acids as DAF-12 receptor ligands.
Org Biomol Chem
; 19(24): 5403-5412, 2021 06 28.
Artigo
Inglês
| MEDLINE | ID: mdl-34056641
3.
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy.
Biochim Biophys Acta
; 1844(10): 1765-72, 2014 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-25062913
4.
Brain natriuretic peptide modulates calcium homeostasis and epidermal growth factor receptor gene signalling in asthmatic airways smooth muscle cells.
Pulm Pharmacol Ther
; 31: 51-4, 2015 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-25722070
5.
Brain natriuretic peptide protects against hyperresponsiveness of human asthmatic airway smooth muscle via an epithelial cell-dependent mechanism.
Am J Respir Cell Mol Biol
; 50(3): 493-501, 2014 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-24074453
6.
Semisynthetic bile acid FXR and TGR5 agonists: physicochemical properties, pharmacokinetics, and metabolism in the rat.
J Pharmacol Exp Ther
; 350(1): 56-68, 2014 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-24784847
7.
Discovery and Structure-Activity Relationships of Novel ssDAF-12 Receptor Modulators.
J Med Chem
; 67(5): 4150-4169, 2024 Mar 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38417155
8.
BH4 domain of bcl-2 protein is required for its proangiogenic function under hypoxic condition.
Carcinogenesis
; 34(11): 2558-67, 2013 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-23836782
9.
Asymmetric synthesis of the four diastereoisomers of a novel non-steroidal farnesoid X receptor (FXR) agonist: role of the chirality on the biological activity.
Bioorg Med Chem
; 21(13): 3780-9, 2013 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23684233
10.
Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives.
Eur J Med Chem
; 261: 115851, 2023 Dec 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37813065
11.
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells.
Eur J Med Chem
; 247: 115022, 2023 Feb 05.
Artigo
Inglês
| MEDLINE | ID: mdl-36549114
12.
Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists.
Bioorg Med Chem
; 20(11): 3429-45, 2012 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22564381
13.
Development of 3α,7α-dihydroxy-6α-ethyl-24-nor-5ß-cholan-23-sulfate sodium salt (INT-767): Process optimization, synthesis and characterization of metabolites.
Eur J Med Chem
; 242: 114652, 2022 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36049273
14.
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.
J Med Chem
; 64(23): 17031-17050, 2021 12 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34843649
15.
Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist.
Mol Pharmacol
; 78(4): 617-30, 2010 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-20631053
16.
From PARP1 to TNKS2 Inhibition: A Structure-Based Approach.
ACS Med Chem Lett
; 11(5): 862-868, 2020 May 14.
Artigo
Inglês
| MEDLINE | ID: mdl-32435397
17.
Btg2 enhances retinoic acid-induced differentiation by modulating histone H4 methylation and acetylation.
Mol Cell Biol
; 26(13): 5023-32, 2006 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-16782888
18.
Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool.
Medchemcomm
; 10(8): 1412-1419, 2019 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31673308
19.
Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists.
ACS Med Chem Lett
; 10(4): 677-681, 2019 Apr 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30996817
20.
Cellular retinoic acid binding protein-II expression and its potential role in skin aging.
Aging (Albany NY)
; 11(6): 1619-1632, 2019 03 18.
Artigo
Inglês
| MEDLINE | ID: mdl-30888968