Detalhe da pesquisa
1.
Synthon-based ligand discovery in virtual libraries of over 11 billion compounds.
Nature
; 601(7893): 452-459, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34912117
2.
Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer.
Mol Ther
; 30(1): 485-500, 2022 01 05.
Artigo
Inglês
| MEDLINE | ID: mdl-34450249
3.
Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK).
Molecules
; 24(22)2019 Nov 06.
Artigo
Inglês
| MEDLINE | ID: mdl-31698822
4.
Mild, Pd-catalyzed stannylation of radioiodination targets.
Bioorg Med Chem Lett
; 25(8): 1761-1764, 2015 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25777268
5.
Illuminating the understudied GPCR-ome.
Drug Discov Today
; 29(3): 103848, 2024 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-38052317
6.
Virtual Screening of a Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target.
ACS Chem Biol
; 19(4): 866-874, 2024 Apr 19.
Artigo
Inglês
| MEDLINE | ID: mdl-38598723
7.
Sandmeyer reaction repurposed for the site-selective, non-oxidizing radioiodination of fully-deprotected peptides: studies on the endogenous opioid peptide α-neoendorphin.
Bioorg Med Chem Lett
; 23(15): 4347-50, 2013 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23796454
8.
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.
J Med Chem
; 65(2): 1313-1328, 2022 01 27.
Artigo
Inglês
| MEDLINE | ID: mdl-34333981
9.
Identification of 4-Anilinoquin(az)oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype.
ChemMedChem
; 17(12): e202200161, 2022 06 20.
Artigo
Inglês
| MEDLINE | ID: mdl-35403825
10.
Synthesis and Characterization of 5-(2-Fluoro-4-[11C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2.
J Med Chem
; 65(3): 2593-2609, 2022 02 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35089713
11.
Design, Synthesis, and Characterization of [18F]mG2P026 as a High-Contrast PET Imaging Ligand for Metabotropic Glutamate Receptor 2.
J Med Chem
; 65(14): 9939-9954, 2022 07 28.
Artigo
Inglês
| MEDLINE | ID: mdl-35802702
12.
Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas.
Sci Adv
; 8(25): eabn3471, 2022 06 24.
Artigo
Inglês
| MEDLINE | ID: mdl-35731869
13.
Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series.
RSC Med Chem
; 12(1): 129-136, 2021 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34046605
14.
Predilection for developing a hematogenous orthopaedic implant-associated infection in older versus younger mice.
J Orthop Surg Res
; 16(1): 556, 2021 Sep 14.
Artigo
Inglês
| MEDLINE | ID: mdl-34521424
15.
Development of a potent and selective chemical probe for the pleiotropic kinase CK2.
Cell Chem Biol
; 28(4): 546-558.e10, 2021 04 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33484635
16.
A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
J Med Chem
; 63(23): 14626-14646, 2020 12 10.
Artigo
Inglês
| MEDLINE | ID: mdl-33215924
17.
Quantifying CDK inhibitor selectivity in live cells.
Nat Commun
; 11(1): 2743, 2020 06 02.
Artigo
Inglês
| MEDLINE | ID: mdl-32488087
18.
SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K.
ACS Med Chem Lett
; 11(3): 340-345, 2020 Mar 12.
Artigo
Inglês
| MEDLINE | ID: mdl-32184967
19.
Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone.
Bone Res
; 6: 13, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-29707402
20.
Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets.
JCI Insight
; 3(17)2018 09 06.
Artigo
Inglês
| MEDLINE | ID: mdl-30185667