Detalhe da pesquisa
1.
Synthesis of Deuterated Endochin-Like Quinolones.
J Labelled Comp Radiopharm
; 67(5): 186-196, 2024 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38661253
2.
Babesia duncani as a Model Organism to Study the Development, Virulence, and Drug Susceptibility of Intraerythrocytic Parasites In Vitro and In Vivo.
J Infect Dis
; 226(7): 1267-1275, 2022 09 28.
Artigo
Inglês
| MEDLINE | ID: mdl-35512141
3.
Effective Therapy Targeting Cytochrome bc1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection.
Antimicrob Agents Chemother
; 65(9): e0066221, 2021 08 17.
Artigo
Inglês
| MEDLINE | ID: mdl-34152821
4.
Novel Endochin-Like Quinolones Exhibit Potent In Vitro Activity against Plasmodium knowlesi but Do Not Synergize with Proguanil.
Antimicrob Agents Chemother
; 64(5)2020 04 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32094134
5.
Orally Bioavailable Endochin-Like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondii Brain Cysts.
Antimicrob Agents Chemother
; 64(9)2020 08 20.
Artigo
Inglês
| MEDLINE | ID: mdl-32540978
6.
Improving solubility and oral bioavailability of a novel antimalarial prodrug: comparing spray-dried dispersions with self-emulsifying drug delivery systems.
Pharm Dev Technol
; 25(5): 625-639, 2020 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-32031478
7.
ELQ-331 as a prototype for extremely durable chemoprotection against malaria.
Malar J
; 18(1): 291, 2019 Aug 27.
Artigo
Inglês
| MEDLINE | ID: mdl-31455339
8.
Genetic Evidence for Cytochrome b Qi Site Inhibition by 4(1H)-Quinolone-3-Diarylethers and Antimycin in Toxoplasma gondii.
Antimicrob Agents Chemother
; 61(2)2017 02.
Artigo
Inglês
| MEDLINE | ID: mdl-27919897
9.
Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria.
Antimicrob Agents Chemother
; 60(8): 4853-9, 2016 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27270285
10.
ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.
Antimicrob Agents Chemother
; 59(9): 5555-60, 2015 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-26124159
11.
Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis.
ACS Infect Dis
; 10(4): 1405-1413, 2024 Apr 12.
Artigo
Inglês
| MEDLINE | ID: mdl-38563132
12.
Long-acting intramuscular injections of ELQ-331, an antimalarial agent.
Eur J Pharm Sci
; 198: 106795, 2024 May 08.
Artigo
Inglês
| MEDLINE | ID: mdl-38729224
13.
Sontochin as a guide to the development of drugs against chloroquine-resistant malaria.
Antimicrob Agents Chemother
; 56(7): 3475-80, 2012 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-22508305
14.
A New Scalable Synthesis of ELQ-300, ELQ-316, and other Antiparasitic Quinolones.
Org Process Res Dev
; 25(8): 1841-1852, 2021 Aug 20.
Artigo
Inglês
| MEDLINE | ID: mdl-35110959
15.
Endochin-like quinolone-300 and ELQ-316 inhibit Babesia bovis, B. bigemina, B. caballi and Theileria equi.
Parasit Vectors
; 13(1): 606, 2020 Dec 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33272316
16.
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
J Med Chem
; 63(11): 6179-6202, 2020 06 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32390431
17.
Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages.
PLoS One
; 14(4): e0214023, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-30964863
18.
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.
J Med Chem
; 62(7): 3475-3502, 2019 04 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30852885
19.
Endochin-Like Quinolones Exhibit Promising Efficacy Against Neospora Caninum in vitro and in Experimentally Infected Pregnant Mice.
Front Vet Sci
; 5: 285, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-30510935
20.
Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis.
ACS Infect Dis
; 4(11): 1574-1584, 2018 11 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30117728