Detalhe da pesquisa
1.
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.
Nature
; 611(7937): 769-779, 2022 11.
Artigo
Inglês
| MEDLINE | ID: mdl-36385529
2.
iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss.
Glia
; 72(2): 452-469, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-37969043
3.
Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.
Mol Syst Biol
; 16(12): e9819, 2020 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33289969
4.
Modeling Alzheimer's disease with iPSC-derived brain cells.
Mol Psychiatry
; 25(1): 148-167, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31391546
5.
Acetaminophen Relieves Inflammatory Pain through CB1 Cannabinoid Receptors in the Rostral Ventromedial Medulla.
J Neurosci
; 38(2): 322-334, 2018 01 10.
Artigo
Inglês
| MEDLINE | ID: mdl-29167401
6.
GABAA receptor subtypes in the mouse brain: Regional mapping and diazepam receptor occupancy by in vivo [18F]flumazenil PET.
Neuroimage
; 150: 279-291, 2017 04 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28192273
7.
Nanoparticle-Mediated Delivery of Anti-PU.1 siRNA via Localized Intracisternal Administration Reduces Neuroinflammation.
Adv Mater
; 36(8): e2309225, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-38018280
8.
A virus-like particle-based anti-nerve growth factor vaccine reduces inflammatory hyperalgesia: potential long-term therapy for chronic pain.
J Immunol
; 186(3): 1769-80, 2011 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21191068
9.
A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation.
J Exp Med
; 220(11)2023 11 06.
Artigo
Inglês
| MEDLINE | ID: mdl-37642942
10.
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia.
Sci Transl Med
; 13(583)2021 03 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33658354
11.
Mice lacking spinal α2GABAA receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype.
Brain Res
; 1741: 146889, 2020 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32439345
12.
TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABAA receptors.
Neuropharmacology
; 143: 71-78, 2018 12.
Artigo
Inglês
| MEDLINE | ID: mdl-30240781
13.
Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors.
Nat Commun
; 9(1): 3230, 2018 08 13.
Artigo
Inglês
| MEDLINE | ID: mdl-30104684
14.
The positive allosteric GABAB receptor modulator rac-BHFF enhances baclofen-mediated analgesia in neuropathic mice.
Neuropharmacology
; 108: 172-8, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27108932
15.
The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia.
Neuropharmacology
; 109: 366-375, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27392635
16.
Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain.
J Clin Invest
; 126(7): 2547-60, 2016 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27270175
17.
Restoring the spinal pain gate: GABA(A) receptors as targets for novel analgesics.
Adv Pharmacol
; 73: 71-96, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25637438
18.
Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype.
Nat Commun
; 6: 6803, 2015 Apr 13.
Artigo
Inglês
| MEDLINE | ID: mdl-25865415
19.
Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla.
Neuropharmacology
; 98: 78-89, 2015 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-25839900
20.
Targeted ablation, silencing, and activation establish glycinergic dorsal horn neurons as key components of a spinal gate for pain and itch.
Neuron
; 85(6): 1289-304, 2015 Mar 18.
Artigo
Inglês
| MEDLINE | ID: mdl-25789756