Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 103
Filtrar
1.
J Oral Maxillofac Surg ; 80(7): 1272-1283, 2022 07.
Artigo em Inglês | MEDLINE | ID: mdl-35378095

RESUMO

PURPOSE: Surgical reconstruction after segmental mandibulectomy in patients with oral cancer commonly requires implantation of titanium plates, which cause metallic artifacts in CT examinations detrimental for image quality. Therefore, the aim of the present study was to evaluate CT artifacts and image quality of the polymer plate materials polyetheretherketone (PEEK), polyetherketoneketone (PEKK), polyphenylsulfone (PPSU), and polyethylene (PE) in mandible reconstruction. METHODS: Five plates (titanium, PEEK, PEKK, PPSU, and PE) were successively surgically inserted in a human cadaveric specimen using eight (1) titanium and (2) zirconium oxide screws. Streak and blooming artifacts were assessed in 1 mm CT scans with and without metallic artifact reduction algorithms (MAR) in this cross-sectional study. The different plate materials were analyzed for their effect on Hounsfield unit (HU) values resulting in streak artifacts. Blooming artifacts were measured as virtual growth of plates compared to actual size. Subjective image quality was assessed by 3 independent observers. Statistics were conducted by multifactorial ANOVA and Bonferroni's post hoc test. RESULTS: Titanium (182.42 HU; SD ± 3.09) was associated with significantly more streak and blooming artifacts compared to the polymers PEEK (86.41 HU; SD ± 1.72; P < .001), PEKK (85.50 HU; SD ± 2.75; P < .001), PPSU (85.51 HU; SD ± 1.97; P < .001), and PE (85.52 HU; SD ± 3.33; P < .001) implants. No significant differences could be seen between the screw types (titanium vs zirconium oxide) (P = .75) or the activation or inactivation of MAR (P = .85). Image quality was best for PE and worst for titanium implants in combination with zirconium oxide screws. CONCLUSIONS: Polymers plate materials PEEK, PEKK, PPSU, and PE significantly reduce CT artifacts and improve image quality facilitating the radiological interpretation of implant surrounding tissues. This effect is beneficial for radiological tumor follow-up and CT-based planning of adjuvant radiotherapy.


Assuntos
Artefatos , Implantes Dentários , Benzofenonas , Estudos Transversais , Humanos , Cetonas , Polietileno , Polietilenoglicóis , Polímeros , Titânio , Tomografia Computadorizada por Raios X/métodos
2.
Int J Mol Sci ; 23(24)2022 Dec 11.
Artigo em Inglês | MEDLINE | ID: mdl-36555353

RESUMO

Titanium and stainless steel are commonly known as osteosynthesis materials with high strength and good biocompatibility. However, they have the big disadvantage that a second operation for hardware removal is necessary. Although resorbable systems made of polymers or magnesium are increasingly used, they show some severe adverse foreign body reactions or unsatisfying degradation behavior. Therefore, we started to investigate molybdenum as a potential new biodegradable material for osteosynthesis in craniomaxillofacial surgery. To characterize molybdenum as a biocompatible material, we performed in vitro assays in accordance with ISO Norm 10993-5. In four different experimental setups, we showed that pure molybdenum and molybdenum rhenium alloys do not lead to cytotoxicity in human and mouse fibroblasts. We also examined the degradation behavior of molybdenum by carrying out long-term immersion tests (up to 6 months) with molybdenum sheet metal. We showed that molybdenum has sufficient mechanical stability over at least 6 months for implants on the one hand and is subject to very uniform degradation on the other. The results of our experiments are very promising for the development of new resorbable osteosynthesis materials for craniomaxillofacial surgery based on molybdenum.


Assuntos
Implantes Absorvíveis , Molibdênio , Animais , Camundongos , Humanos , Materiais Biocompatíveis , Ligas , Magnésio , Teste de Materiais
3.
HNO ; 69(11): 899-906, 2021 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-33337508

RESUMO

BACKGROUND: Psycho-oncological screening is a useful tool to ascertain whether patients need special support. Currently, patients are asked mainly about their acute problems. Stable internal and external risk factors and preventive patient characteristics are largely disregarded. The newly developed Düsseldorf Screening Tool (DST) captures distress through stable traits, social support, and the patient's coping style. The aim of this study was to validate the DST using the Distress-Thermometer (DT) and Basic Documentation for Psycho-Oncology (PO-Bado). METHODS: A total of 126 patients with head and neck squamous cell carcinoma were investigated. To determine the cut-off value, receiver operating curves (ROC) curves were calculated. As a measure of quality, area under the curve (AUC) values are given. Sensitivity and specificity were established for each gold standard questionnaire. RESULTS: Compared to the DT and PO-Bado, the discrimination ability of the DST is good, with AUC values of 0.62 to 0.80. With a DT cut-off value of 5, a sensitivity of 84.2% with a specificity of 37.0% can be stated. Compared to PO-Bado, a sensitivity value of 92.9% with a specificity of 43.6% can be reported. CONCLUSION: The results show that a trait-based approach to identify patients' level of psychological distress can purposefully and safely assess cancer patients' stress level. A new approach to screening in psycho-oncology has thus emerged.


Assuntos
Neoplasias de Cabeça e Pescoço , Neoplasias , Angústia Psicológica , Detecção Precoce de Câncer , Humanos , Programas de Rastreamento , Neoplasias/diagnóstico , Psicometria , Estresse Psicológico/diagnóstico , Inquéritos e Questionários
4.
Clin Oral Investig ; 23(11): 4145-4156, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30834990

RESUMO

OBJECTIVES: Sialolithiasis is the most common cause of chronic sialadenitis of the submandibular gland (SMG). Symptomatic superficial lobe stones are often treated by submandibulectomy. A gland preserving operation allows for transoral stone removal through endoscopically assisted sialolithotomy. Herein, we provide clinical and sonographical follow-up data in patients who underwent sialolithotomy under general anesthesia. MATERIALS AND METHODS: Sixty patients treated at the Department of Oral and Maxillofacial Surgery at Düsseldorf University Hospital for superficial lobe sialolithiasis of SMG were included in this study. All received transoral sialolithotomy under general anesthesia. Follow-up was conducted via standardized patient questionnaires, clinical examination, and B-mode and color Doppler sonography. RESULTS: Mean patient age was 48.9 years. 56.6% of right and 43.4% of left SMG were affected. Mean follow-up was 45 months. Fifty-five of 59 detected stones could be removed. Mean operation time was 71 min. 3.3% of patients reported recurrent episodes of postoperative pain and 10% felt recurrent episodes of gland swelling. Persistent postoperative lingual nerve hypesthesia was described in one patient. No facial nerve damages occurred. Salivary flow rates remained reduced in most of the affected glands upon stone removal. Sonographical follow-up data of the previously affected SMG after intraoral endoscopy-assisted sialolithotomy showed a regular gland size in 70.8% of cases, a parenchyma free of inflammation in 93.8%, and without signs of fibrosis in 72.9% of cases. 68.7% of patients showed a regular structure of Wharton's duct at time of follow-up. In total, 89.6% of patients were diagnosed stone-free within both glands on follow-up. No case required subsequent submandibulectomy. CONCLUSIONS: Sialolithotomy of Wharton's duct for removal of stones from the SMG's superficial lobe is a promising alternative to submandibulectomy. CLINICAL RELEVANCE: Reduction of postoperative morbidity through endoscopically assisted sialolithotomy for removal of superficial lobe stones from SMG. TRIAL REGISTRATION: Ethics Committee of Heinrich-Heine-University Düsseldorf (no. 5586).


Assuntos
Cálculos das Glândulas Salivares , Glândula Submandibular , Endoscopia , Humanos , Ductos Salivares , Cálculos das Glândulas Salivares/diagnóstico por imagem , Cálculos das Glândulas Salivares/cirurgia , Glândula Submandibular/diagnóstico por imagem , Ultrassonografia
5.
J Oral Maxillofac Surg ; 73(6): 1113-8, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25981837

RESUMO

PURPOSE: Advances in technology have allowed increasing degrees of accuracy in the treatment of orbital deformities. The purpose of this study was to compare the accuracy of pre-bent titanium mesh (PBTM) and selective laser-melted patient-specific implants (PSIs) in unilateral orbital reconstruction after traumatic injury. The authors hypothesized that selective laser-melted PSIs would more accurately reconstruct the orbit. MATERIALS AND METHODS: A retrospective review of 34 cases of primary reconstruction of unilateral orbital fractures treated using selective laser-melted PSIs (group 1, n = 17) or PBTM (group 2, n = 17) was performed. The primary outcome measurements were orbital volume excess and the anterior, medial, and posterior intraorbital angles. The Mann-Whitney U test was used to assess the difference in orbital volume and angular deviation between the 2 groups. The level of statistical significance was set at .05. All P values were 2-sided. RESULTS: The comparison of mean values for the 2 groups showed significant differences for the anterior angle (PBTM: mean, 11.3; standard deviation [SD], 1.8; PSI: mean, 4.1; SD, 0.7; P = .001), but not the medial (PBTM: mean, 11.6; SD, 2.0; PSI: mean, 8.2; SD, 1.9; P = .170) and posterior (PBTM: mean, 10.8, SD, 2.8; PSI: mean, 8.2, SD, 1.4; P = .760) angles between the unaffected and reconstructed orbits. The postoperative difference in volume between the unaffected and reconstructed orbits differed significantly between the 2 study groups (PBTM: mean, 0.6; SD, 0.1; PSI: mean, 0.4; SD, 0.1; P = .029). CONCLUSION: The results of this study suggest that complex orbital fractures can be reconstructed with an even higher degree of accuracy with selective laser-melted PSIs than with PBTM.


Assuntos
Lasers , Fraturas Orbitárias/cirurgia , Procedimentos de Cirurgia Plástica/métodos , Próteses e Implantes , Desenho de Prótese , Cirurgia Assistida por Computador/métodos , Materiais Biocompatíveis/química , Desenho Assistido por Computador , Tomografia Computadorizada de Feixe Cônico/métodos , Seguimentos , Fraturas Cominutivas/cirurgia , Humanos , Imageamento Tridimensional/métodos , Modelos Anatômicos , Órbita/patologia , Procedimentos de Cirurgia Plástica/instrumentação , Estudos Retrospectivos , Telas Cirúrgicas , Titânio/química , Tomografia Computadorizada por Raios X/métodos , Resultado do Tratamento , Interface Usuário-Computador
6.
Clin Oral Investig ; 19(2): 481-8, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24878612

RESUMO

OBJECTIVES: Health-related quality of life (HR-QoL) informations are becoming an important tool for the treatment concept for cancer patients. The purpose of this study was to evaluate how the quality of life depends on the disease severity of pre- and oral cancer patients and which factors influence their quality of life. MATERIALS AND METHODS: During this study, 106 patients with a premalignant oral lesion, 174 patients with oral squamous cell carcinoma (OSSC) as well as 21 patients with a recurrence of OSSC were asked about their oral health-related quality of life. Additionally, the UW-QOLv4 was used to record the psychological and clinical symptoms from which the patients of the three groups are suffering. RESULTS: Significant differences with respect to oral HR-QoL of life between the groups could be evaluated. Patients with a recurrence have the lowest and patients with precancer the highest HR-QoL. Within the groups, there is a difference regarding the significance of the psychological factors. The lowest values were achieved for mood within all three groups. Anxiety is of key importance for the precancer group whereas appearance and activity are of importance for the patients having a tumor. The patients of the recurrence group are heavily affected by all factors. CONCLUSIONS: The quality of life differs depending on the disease. The patients of the recurrence group have the lowest oral health-related quality of life for all aspects analyzed, and they are suffering the most with respect to the psychological dimensions of the UW-QOLv4. CLINICAL RELEVANCE: The present study examined the quality of life depending on the severity of the disease of pre- and oral cancer patients and which factors significantly influenced their quality of life. The evaluated findings of relevant variables may have therapeutic relevance for the multidisciplinary treatment of oral cancer patients in the future.


Assuntos
Neoplasias Bucais/fisiopatologia , Lesões Pré-Cancerosas/fisiopatologia , Qualidade de Vida , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/patologia , Lesões Pré-Cancerosas/patologia
7.
J Relig Health ; 54(1): 173-86, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25723043

RESUMO

In the present study, the coping strategies of stroke patients were examined. An intercultural comparison between patients from Germany and Pakistan was made to investigate the impact of culture on coping processes and the need to consider these in the therapy of stroke patients. Six self-completed questionnaires were given to 53 stroke patients from Germany and 44 from Pakistan. In addition to coping processes, potential determinants on coping such as religiosity, social support and locus of control were examined. Analysis suggested both samples to be characterized by similar coping processes,but the German and Pakistani patients eventually differ in the extent they use these psychosocial determinants. This study provides modern treatment strategies for coping with stroke.


Assuntos
Adaptação Psicológica , Comparação Transcultural , Religião e Medicina , Acidente Vascular Cerebral/etnologia , Acidente Vascular Cerebral/psicologia , Inquéritos e Questionários , Adulto , Idoso , Feminino , Alemanha , Humanos , Controle Interno-Externo , Masculino , Pessoa de Meia-Idade , Paquistão/etnologia , Estudos Prospectivos , Psicometria , Religião , Apoio Social , Estatística como Assunto , Tradução
8.
J Relig Health ; 54(6): 2142-54, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25204789

RESUMO

Little research has been done on comparing confessions regarding mental health. In the present study, 320 people (78 Buddhists, 77 Catholics, 89 Protestants and 79 Muslims) were compared in terms of their symptom severity. Buddhists and Protestants had lower scores than Catholics and Muslims for obsessive-compulsive behavior and hostility. Muslim group had the highest comparative scores for psychoticism. Buddhists and Protestants had comparatively low scores for paranoid ideation and overall symptom severity, with Catholics and Muslims having high ones. Results reveal that confession should be taken in account in psychological research and diagnosis, since it is explicitly associated with psychological well-being.


Assuntos
Revelação , Transtornos Mentais/psicologia , Religião e Psicologia , Adaptação Psicológica , Adolescente , Adulto , Idoso , Budismo/psicologia , Catolicismo/psicologia , Feminino , Humanos , Islamismo/psicologia , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Protestantismo/psicologia , Índice de Gravidade de Doença , Adulto Jovem
9.
Support Care Cancer ; 22(11): 2981-6, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24897962

RESUMO

PURPOSE: Oral tumours lead to critical reductions in quality of life and well being. Coping with illness is a multidimensional construct that is affected by various factors, including social structure, social support, locus of control and religious considerations. However, the effect of personality on coping with illness has hardly been studied. In this context, just one personality model has been developed, but this defines personality in very wide dimensions. Therefore, this study considered the personality factors related to health and disease and aimed to identify potential clinical applications in patients with oral cancer. METHODS: We enrolled 104 patients suffering from oral cancer. Participants were asked about their personality and illness coping styles using the Freiburg Personality Inventory and the Freiburg Questionnaire of Coping with Illness, respectively. RESULTS: Regression analyses revealed that specific personality structures of the patients determine their way of coping. Patients primarily used active and problem-oriented coping styles; spirituality, depressive coping and minimization were used less frequently. CONCLUSIONS: The results demonstrate that personality affects coping behaviour. When treating patients, both situational factors and personality traits affect how patients cope with their disease. We note that it is important to give particular attention to patients who use depressive coping styles, as these patients are often incapable of coping with their diseases without external support.


Assuntos
Adaptação Psicológica , Carcinoma de Células Escamosas/psicologia , Neoplasias Bucais/psicologia , Determinação da Personalidade , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Qualidade de Vida , Apoio Social , Inquéritos e Questionários , Adulto Jovem
10.
Facial Plast Surg ; 30(5): 518-27, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25397707

RESUMO

Decreasing visual acuity secondary to orbital trauma or orbital and anterior skull base surgery may be caused by either sudden space-occupying intraorbital lesions, including retrobulbar hemorrhage (RBH), or direct damage to the prechiasmatic pathway. Contrary to traumatic optic neuropathy, RBH must be diagnosed and treated immediately to prevent permanent damage to the visual system. Therefore, monitoring and handling of visual pathway damage are mandatory. Flash visual evoked potentials and electroretinograms can provide evidence of the status of conductivity of the visual pathway when clinical assessment is not feasible. Both are thus essential diagnostic procedures not only for primary diagnosis but also for intraoperative evaluation. In case of RBH surgical decompression is compulsory. However, traumatic optic neuropathy does not respond to either corticosteroids or optic canal surgery. Modern craniomaxillofacial surgery requires detailed consideration of the diagnosis and treatment of traumatic visual pathway damage with the ultimate goal of preserving visual acuity.


Assuntos
Traumatismos do Nervo Óptico/diagnóstico , Traumatismos do Nervo Óptico/terapia , Algoritmos , Traumatismos Craniocerebrais/complicações , Diagnóstico Diferencial , Diagnóstico por Imagem , Potenciais Evocados Visuais , Humanos , Traumatismos do Nervo Óptico/fisiopatologia , Acuidade Visual
11.
Healthcare (Basel) ; 12(6)2024 Mar 09.
Artigo em Inglês | MEDLINE | ID: mdl-38540584

RESUMO

The diagnosis of a chronic disease, such as multiple sclerosis, has both psychological and physical effects. Living with the disease and its uncertain consequences requires a great deal of psychological resilience in order to employ more comprehensive coping strategies in stressful situations. This study investigated the effect of a four-week online self-directed resilience training program on the perception of psychological resilience among multiple sclerosis patients. A total of 94 MS patients were recruited for a randomised controlled trial. The experimental group underwent a 28-day online self-directed training program consisting of daily exercises aimed at strengthening a resilient mindset. Psychological resilience was measured through self-assessment immediately before, immediately after, and three months after the training. A repeated measures ANOVA revealed a statistically significant improvement in the perception of four factors related to stress: perceived worries, tension, joy, and demands. Two resilience coping strategies were measured, of which one, a resilient orientation, improved significantly in the short and long term. The study suggests that online self-directed resilience training might provide an easily accessible, low-cost option for patients with MS to improve their psychological resilience. This is a pilot study to assess the general applicability to people with MS. Future studies should examine the transferability of results in relation to disease stage and co-morbidities.

12.
Head Face Med ; 20(1): 39, 2024 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-39044223

RESUMO

BACKGROUND: Postoperative delirium (POD) in the oral and maxillofacial settings has gained more attention in recent decades. Due to advances in medical technology, treatment possibilities have expanded treatment for elderly and frail patients. This scoping review explores the correlation between POD and oral and maxillofacial surgery, summarizing screening and management protocols and identifying risk factors in this surgical field. METHODS: This review follows the Scoping Review extension of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA-ScR). A comprehensive literature search was performed using multiple databases, focusing on articles published from 2002 to 2023 that discuss delirium in oral and maxillofacial surgery settings. The review was registered beforehand in the Open Science Framework ( https://osf.io/r2ebc ). RESULTS: From the initial 644 articles, 68 met the inclusion criteria. These studies highlighted the significant heterogeneity in POD diagnosis methods. The review identifies multiple risk factors across the preoperative, intraoperative, and postoperative phases that influence the occurrence of POD. Significant and independent risk factors in multiple regression analysis were highlighted, creating a clinical prediction list for the occurrence of POD. CONCLUSION: It is crucial to preoperatively identify patients at risk for POD and actively modify these risks throughout the patient's hospital stay. Implementing nonpharmacological preventive measures for at-risk patients is recommended to decrease the incidence of POD. Future research should focus on creating standardized specialty-specific protocols incorporating validated assessment tools and addressing the full spectrum of risk factors associated with POD.


Assuntos
Delírio , Procedimentos Cirúrgicos Bucais , Complicações Pós-Operatórias , Humanos , Procedimentos Cirúrgicos Bucais/efeitos adversos , Procedimentos Cirúrgicos Bucais/métodos , Complicações Pós-Operatórias/epidemiologia , Delírio/etiologia , Delírio/diagnóstico , Fatores de Risco , Delírio do Despertar/epidemiologia , Delírio do Despertar/diagnóstico , Delírio do Despertar/etiologia
13.
Cancers (Basel) ; 16(7)2024 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-38611070

RESUMO

The preparation and implementation of interdisciplinary oncological case reviews are time-consuming and complex. The variety of clinical and radiological information must be presented in a clear and comprehensible manner. Only if all relevant patient-specific information is demonstrated in a short time frame can well-founded treatment decisions be made on this basis. Mixed reality (MR) technology as a multimodal interactive user interface could enhance understanding in multidisciplinary collaboration by visualising radiological or clinical data. The aim of the work was to develop an MR-based software prototype for a head and neck tumour board (HNTB) to support clinical decision-making. The article describes the development phases and workflows in the planning and creation of a MR-based software prototype that were required to meet the multidisciplinary characteristics of a HNTB.

14.
Sci Rep ; 14(1): 11665, 2024 05 22.
Artigo em Inglês | MEDLINE | ID: mdl-38778125

RESUMO

The concept of narcissism encompasses various personality traits, including cognitive, emotional and behavioural characteristics, which often lead to difficulties in maintaining a healthy self-esteem. This study examines the prevalence of narcissism traits (Admiration and Rivalry) in the surgical profession and their association with age, gender and professional experience. A total of 1390 participants (408 women, 982 men) took part in an online survey. The results show that female participants have significantly lower levels of rivalry than male colleagues. Additionally, age was found to be inversely correlated with both facets of narcissism, demonstrating that levels of narcissism decrease as age increases. Participants who are still in education tend to show higher levels of both facets. These results improve our understanding of personality traits in surgery and provide valuable insights for researchers and practitioners.


Assuntos
Narcisismo , Cirurgiões , Humanos , Feminino , Masculino , Adulto , Pessoa de Meia-Idade , Cirurgiões/psicologia , Inquéritos e Questionários , Autoimagem , Personalidade , Fatores Sexuais
15.
J Maxillofac Oral Surg ; 23(1): 145-151, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38312982

RESUMO

The odontogenic keratocyst (OKC) is a benign but locally aggressive growing lesion that infiltrates the bone and surrounding tissue. It is characterized by high rates of recurrence along with rapid growth. Different forms of partly successful treatment therapies are reported. The retrospective study at hand examined 114 patients with OKC treated over a period of 20 years. Data extracted includes gender, age, location, previous treatment for the lesion, surgery, outcome, recurrence rate and follow-up. 63.1% of the patients underwent cystectomy, 22.5% by cystectomy and carnoy solution, 7.2% by cystectomy, and curettage, 4.5% by cystostomy and 2.7% by partial resection. In this study, no significant differences could be observed regarding the surgical method. Most recurrences occurred with 91.9% in the mandible with an average size of 5.5 cm2 and increased in women. Within a mean follow-up time of 3.6 years the recurrence rate was 36.9%, on average after 36 months. Recurrences were most frequently diagnosed at the age of 31-50 (43.9%). Despite numerous studies, there is still no unanimous opinion on an effective therapy for OKC. However, precise resection of OKC can be facilitated by preoperative 3D-imaging and virtual planning.

16.
J Funct Biomater ; 15(5)2024 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-38786630

RESUMO

Titanium continues to be the gold standard in the field of osteosynthesis materials. This also applies to pediatric craniofacial surgery. Various resorbable materials have already been developed in order to avoid costly and risky second operations to remove metal in children. However, none of these resorbable materials have been able to completely replace the previous gold standard, titanium, in a satisfactory manner. This has led to the need for a new resorbable osteosynthesis material that fulfills the requirements for biocompatibility, stability, and uniform resorption. In our previous in vitro and in vivo work, we were able to show that molybdenum fulfills these requirements. To further confirm these results, we conducted a proof of concept in four domestic pigs, each of which was implanted with a resorbable molybdenum implant. The animals were then examined daily for local inflammatory parameters. After 54 days, the animals were euthanized with subsequent computer tomography imaging. We also removed the implants together with the surrounding tissue and parts of the spleen, liver, and kidney for histopathological evaluation. The molybdenum implants were also analyzed metallographically and using scanning electron microscopy. A blood sample was taken pre- and post-operatively. None of the animals showed clinical signs of inflammation over the entire test period. Histopathologically, good tissue compatibility was found. Early signs of degradation were observed after 54 days, which were not sufficient for major resorption. Resorption is expected with longer in situ residence times based on results of similar earlier investigations.

17.
J Clin Med ; 13(5)2024 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-38592134

RESUMO

Introduction: The use of 3D-printed aortic models for the creation of surgeon-modified endoprostheses represents a promising avenue in aortic surgery. By focusing on the potential impact of sterilization on model integrity and geometry, this report sheds light on the suitability of these models for creating customized endoprostheses. The study presented here aimed to investigate the safety and viability of 3D-printed aortic models in the context of sterilization processes and subsequent remodeling. Methods: The study involved the fabrication of 3D-printed aortic models using patient-specific imaging data and established additive manufacturing techniques. Five identical aortic models of the same patient were printed. Two models were subjected to sterilization and two to disinfection using commonly employed methods, and one model remained untreated. The models were checked by in-house quality control for deformation (heat map analyses) after the sterilization and disinfection processes. Three models (sterilized, disinfected, and untreated) were sent for ex-house (Lufthansa Technik, AG, Materials Technologies and Central Laboratory Services, Hamburg, Germany) evaluation and subsequent quantification of possible structural changes using advanced imaging and measurement technologies (macroscopic and SEM/EDX examinations). After sterilization and disinfection, each aortic model underwent sterility checks. Results: Based on macroscopic and SEM/EDX examinations, distinct evidence of material alterations attributed to a treatment process, such as a cleaning procedure, was not identified on the three implants. Comparative material analyses conducted via the EDX technique yield consistent results for all three implants. Disinfected and sterilized models tested negative for common pathogens. Conclusions: The evaluation of 3D-printed aortic models' safety after sterilization as well as their suitability for surgeon-modified endoprostheses is a critical step toward their clinical integration. By comprehensively assessing changes in model integrity and geometry after sterilization, this research has contributed to the broader understanding of the use of 3D-printed models for tailor-made endovascular solutions. As medical technologies continue to evolve, research endeavors such as this one can serve as a foundation for harnessing the full potential of 3D printing to advance patient-centered care in aortic surgery.

18.
World J Surg Oncol ; 11: 73, 2013 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-23506357

RESUMO

BACKGROUND: Lymphomas of the orbit and orbital adnexae are rare tumors, comprising only 1% of all non-Hodgkin's lymphoma. The majority of non-Hodgkin's lymphomas of the orbit are extranodal marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissue type. Because of nonspecific clinical signs and symptoms, some diagnostic delay may occur. The purpose of the study was to evaluate the diagnostic approach in orbital lymphomas and to analyze their treatment outcome. METHODS: In the period from 2005 to 2012, from a group of 135 patients with tumors of the orbit, we identified 11 patients diagnosed with orbital lymphoma. This patient cohort was reviewed retrospectively. RESULTS: The patient group consisted of 11 patients (seven females, male males) with a median age of 57.7 years (range 42 to 88 years). Orbital swelling, pain and motility impairment were the leading clinical symptoms. Diagnosis was confirmed by surgical biopsy. Depending on the anatomic location of the tumor, a surgical biopsy was taken using a blepharoplasty incision, a lateral orbitotomy or a navigation-guided biopsy. The predominant histology was extranodal non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue type (82%). All patients underwent complete clinical staging. These were clinical stage IEA in seven patients, and stages IIEA (n = 2) and IIIEA (n = 2) in four patients . Patients in stage IEA were treated with radiation therapy alone, with radiation doses between 25 and 40 Gy, and patients with stage IIEA received systemic chemotherapy with bendamustin/rituximab. Those two patients diagnosed with diffuse large B-cell lymphoma and mantle cell lymphoma received systemic chemotherapy according to the R-CHOP protocol. CONCLUSIONS: Owing to unspecific clinical symptoms, some diagnostic delay may occur in orbital lymphoma. If unspecific orbital symptoms are present, adequate imaging studies followed by early surgical biopsy will contribute to early diagnosis. Once diagnosis is established and staging is complete, radiation therapy is the recommended treatment for stage IEA patients. Systemic chemotherapy is indicated in selected stage IIEA patients and in patients with stage IIIEA disease.


Assuntos
Linfoma de Zona Marginal Tipo Células B/mortalidade , Linfoma não Hodgkin/mortalidade , Linfoma/mortalidade , Neoplasias Orbitárias/mortalidade , Adulto , Idoso , Idoso de 80 Anos ou mais , Terapia Combinada , Feminino , Seguimentos , Humanos , Linfoma/diagnóstico , Linfoma/terapia , Linfoma de Zona Marginal Tipo Células B/diagnóstico , Linfoma de Zona Marginal Tipo Células B/terapia , Linfoma não Hodgkin/diagnóstico , Linfoma não Hodgkin/terapia , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Neoplasias Orbitárias/diagnóstico , Neoplasias Orbitárias/terapia , Prognóstico , Estudos Retrospectivos , Taxa de Sobrevida , Tomografia Computadorizada por Raios X
19.
Schweiz Monatsschr Zahnmed ; 123(10): 883-94, 2013.
Artigo em Francês, Alemão | MEDLINE | ID: mdl-24203487

RESUMO

INTRODUCTION: Even if a mortal incident occurs rarely in a dentists daily routine there is a chance of it. The entire team has to face a great challenge then. Stress and incertainty are leading to mistakes and cost precious time which is not given for treating due to emergency. MATERIAL: Usual emergencies helped developing emergency kits which should make it easy for the practise team to act right and aim orientated in case of emergency. Therefore the combination for an as much efficient as possible state of those kits has priority. Through these the acting procedures turn out easier and more secure. RESULT: The management in case of emergency could be highly improved through the developing of emergency kits. The acting procedures turn out easier and more secure. The possibility for mistakes decreases.


Assuntos
Assistência Odontológica , Tratamento de Emergência , Equipamentos e Provisões , Eficiência , Humanos , Preparações Farmacêuticas
20.
J Pers Med ; 13(1)2023 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-36675809

RESUMO

This technical note describes the technique of plasma electrolytic polishing on orbital patient-specific implants and demonstrates clinical handling and use by the insertion of a plasma electrolytic polished orbital implant into a patient.

SELEÇÃO DE REFERÊNCIAS
Detalhe da pesquisa