Detalhe da pesquisa
1.
Robust and High-Throughput Analytical Flow Proteomics Analysis of Cynomolgus Monkey and Human Matrices With Zeno SWATH Data-Independent Acquisition.
Mol Cell Proteomics
; 22(6): 100562, 2023 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-37142056
2.
Multiplex Hybrid Antigen-Capture LC-MRM Quantification in Sera and Nasal Lining Fluid of AZD7442, a SARS-CoV-2-Targeting Antibody Combination.
Anal Chem
; 94(43): 14835-14845, 2022 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36269894
3.
LEGACY: Phase 2a Trial to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamic Effects of the Anti-EL (Endothelial Lipase) Antibody MEDI5884 in Patients With Stable Coronary Artery Disease.
Arterioscler Thromb Vasc Biol
; 41(12): 3005-3014, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34706556
4.
Characterization of Antibody-Drug Conjugate Pharmacokinetics and in Vivo Biotransformation Using Quantitative Intact LC-HRMS and Surrogate Analyte LC-MRM.
Anal Chem
; 93(15): 6135-6144, 2021 04 20.
Artigo
Inglês
| MEDLINE | ID: mdl-33835773
5.
Multifaceted Bioanalytical Methods for the Comprehensive Pharmacokinetic and Catabolic Assessment of MEDI3726, an Anti-Prostate-Specific Membrane Antigen Pyrrolobenzodiazepine Antibody-Drug Conjugate.
Anal Chem
; 92(16): 11135-11144, 2020 08 18.
Artigo
Inglês
| MEDLINE | ID: mdl-32459957
6.
Comprehensive performance evaluation of ligand-binding assay-LC-MS/MS method for co-dosed monoclonal anti-SARS-CoV-2 antibodies (AZD7442).
Bioanalysis
; 16(7): 149-163, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-38385904
7.
Quantitative evaluation of trastuzumab deruxtecan pharmacokinetics and pharmacodynamics in mouse models of varying degrees of HER2 expression.
CPT Pharmacometrics Syst Pharmacol
; 2024 Mar 26.
Artigo
Inglês
| MEDLINE | ID: mdl-38532525
8.
Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells.
Proc Natl Acad Sci U S A
; 107(12): 5477-82, 2010 Mar 23.
Artigo
Inglês
| MEDLINE | ID: mdl-20212119
9.
Multiplex Bioanalytical Methods for Comprehensive Characterization and Quantification of the Unique Complementarity-Determining-Region Deamidation of MEDI7247, an Anti-ASCT2 Pyrrolobenzodiazepine Antibody-Drug Conjugate.
Antibodies (Basel)
; 12(4)2023 Oct 17.
Artigo
Inglês
| MEDLINE | ID: mdl-37873863
10.
Systems Biology and Peptide Engineering to Overcome Absorption Barriers for Oral Peptide Delivery: Dosage Form Optimization Case Study Preceding Clinical Translation.
Pharmaceutics
; 15(10)2023 Oct 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37896196
11.
Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305.
Clin Cancer Res
; 29(6): 1086-1101, 2023 03 14.
Artigo
Inglês
| MEDLINE | ID: mdl-36355054
12.
2022 White Paper on Recent Issues in Bioanalysis: ICH M10 BMV Guideline & Global Harmonization; Hybrid Assays; Oligonucleotides & ADC; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A - Recommendations on Mass Spectrometry, Chromatography and Sample Preparation, Novel Technologies, Novel Modalities, and Novel Challenges, ICH M10 BMV Guideline & Global Harmonization Part 1B - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV, Biomarkers/CDx/BAV, Immunogenicity, Gene & Cell Therapy and Vaccine).
Bioanalysis
; 15(16): 955-1016, 2023 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-37650500
13.
Bioanalytical Methods and Strategic Perspectives Addressing the Rising Complexity of Novel Bioconjugates and Delivery Routes for Biotherapeutics.
BioDrugs
; 36(2): 181-196, 2022 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-35362869
14.
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans.
Sci Transl Med
; 14(635): eabl8124, 2022 03 09.
Artigo
Inglês
| MEDLINE | ID: mdl-35076282
15.
2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A - Recommendations on Endogenous Compounds, Small Molecules, Complex Methods, Regulated Mass Spec of Large Molecules, Small Molecule, PoC & Part 1B - Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine).
Bioanalysis
; 14(9): 505-580, 2022 May.
Artigo
Inglês
| MEDLINE | ID: mdl-35578993
16.
Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches.
J Neurochem
; 116(5): 789-95, 2011 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-20807315
17.
Differences in levels of phosphatidylinositols in healthy and stable Coronary Artery Disease subjects revealed by HILIC-MRM method with SERRF normalization.
PLoS One
; 16(6): e0252426, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34086718
18.
Targeted oral peptide delivery using multi-unit particulates: Drug and permeation enhancer layering approach.
J Control Release
; 338: 784-791, 2021 10 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34499981
19.
Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease.
Sci Rep
; 11(1): 22521, 2021 11 18.
Artigo
Inglês
| MEDLINE | ID: mdl-34795324
20.
First-in-Human, Phase 1 Dose-Escalation Study of Biparatopic Anti-HER2 Antibody-Drug Conjugate MEDI4276 in Patients with HER2-positive Advanced Breast or Gastric Cancer.
Mol Cancer Ther
; 20(8): 1442-1453, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34045233