Detalhe da pesquisa
1.
Single-stranded siRNAs activate RNAi in animals.
Cell
; 150(5): 883-94, 2012 Aug 31.
Artigo
Inglês
| MEDLINE | ID: mdl-22939618
2.
Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics.
Nucleic Acids Res
; 51(4): 1583-1599, 2023 02 28.
Artigo
Inglês
| MEDLINE | ID: mdl-36727438
3.
Systematic Investigation of Tether Length and Phosphorus Configuration in Backbone Constrained Macrocyclic Nucleic Acids to Modulate Binding Kinetics for RNA.
J Org Chem
; 88(6): 3599-3614, 2023 03 17.
Artigo
Inglês
| MEDLINE | ID: mdl-36857642
4.
High-resolution visualization and quantification of nucleic acid-based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS).
Nucleic Acids Res
; 49(1): 1-14, 2021 01 11.
Artigo
Inglês
| MEDLINE | ID: mdl-33275144
5.
Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
Nucleic Acids Res
; 49(16): 9026-9041, 2021 09 20.
Artigo
Inglês
| MEDLINE | ID: mdl-34417625
6.
Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs.
Nucleic Acids Res
; 49(4): 1828-1839, 2021 02 26.
Artigo
Inglês
| MEDLINE | ID: mdl-33544849
7.
Backbone Hydrocarbon-Constrained Nucleic Acids Modulate Hybridization Kinetics for RNA.
J Am Chem Soc
; 144(4): 1941-1950, 2022 02 02.
Artigo
Inglês
| MEDLINE | ID: mdl-35041415
8.
Efficient Gene Suppression by DNA/DNA Double-Stranded Oligonucleotide In Vivo.
Mol Ther
; 29(2): 838-847, 2021 02 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33290725
9.
Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice.
Nucleic Acids Res
; 48(8): 4382-4395, 2020 05 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32182359
10.
Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.
Nucleic Acids Res
; 48(4): 1691-1700, 2020 02 28.
Artigo
Inglês
| MEDLINE | ID: mdl-31980820
11.
Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell.
J Am Chem Soc
; 143(9): 3416-3429, 2021 03 10.
Artigo
Inglês
| MEDLINE | ID: mdl-33626278
12.
Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay.
Nucleic Acids Res
; 47(3): 1110-1122, 2019 02 20.
Artigo
Inglês
| MEDLINE | ID: mdl-30566688
13.
Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle.
Nucleic Acids Res
; 47(12): 6029-6044, 2019 07 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31127296
14.
Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins.
Nucleic Acids Res
; 47(11): 5465-5479, 2019 06 20.
Artigo
Inglês
| MEDLINE | ID: mdl-31034558
15.
Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates.
Nucleic Acids Res
; 47(12): 6045-6058, 2019 07 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31076766
16.
Interaction of ASOs with PC4 Is Highly Influenced by the Cellular Environment and ASO Chemistry.
J Am Chem Soc
; 142(21): 9661-9674, 2020 05 27.
Artigo
Inglês
| MEDLINE | ID: mdl-32374993
17.
The Interaction of Phosphorothioate-Containing RNA Targeted Drugs with Proteins Is a Critical Determinant of the Therapeutic Effects of These Agents.
J Am Chem Soc
; 142(35): 14754-14771, 2020 09 02.
Artigo
Inglês
| MEDLINE | ID: mdl-32786803
18.
Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins.
J Am Chem Soc
; 142(16): 7456-7468, 2020 04 22.
Artigo
Inglês
| MEDLINE | ID: mdl-32202774
19.
Disulfide bridge cross-linking between protein and the RNA backbone as a tool to study RNase H1.
Bioorg Med Chem
; 28(23): 115741, 2020 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32992250
20.
MXD3 antisense oligonucleotide with superparamagnetic iron oxide nanoparticles: A new targeted approach for neuroblastoma.
Nanomedicine
; 24: 102127, 2020 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31783139