Detalhe da pesquisa
1.
Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System.
Chem Res Toxicol
; 36(3): 390-401, 2023 03 20.
Artigo
Inglês
| MEDLINE | ID: mdl-36812109
2.
Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration.
Hepatology
; 74(2): 973-986, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33872408
3.
Expression and enzyme activity of cytochrome P450 enzymes CYP3A4 and CYP3A5 in human skin and tissue-engineered skin equivalents.
Exp Dermatol
; 27(5): 473-475, 2018 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29227563
4.
Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process.
Mol Pharm
; 15(8): 3557-3572, 2018 08 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29944835
5.
Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms.
Arch Toxicol
; 92(2): 557-569, 2018 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-29362863
6.
Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation.
Hepatology
; 64(5): 1743-1756, 2016 11.
Artigo
Inglês
| MEDLINE | ID: mdl-27532775
7.
Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile.
Arch Toxicol
; 91(1): 439-452, 2017 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-27039104
8.
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.
Arch Toxicol
; 91(3): 1385-1400, 2017 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-27344343
9.
Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes.
J Hepatol
; 62(3): 581-9, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25457200
10.
Safety pharmacology--current and emerging concepts.
Toxicol Appl Pharmacol
; 273(2): 229-41, 2013 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23732082
11.
Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury.
Toxicol Sci
; 192(1): 106-116, 2023 03 20.
Artigo
Inglês
| MEDLINE | ID: mdl-36782357
12.
A systems approach reveals species differences in hepatic stress response capacity.
Toxicol Sci
; 196(1): 112-125, 2023 10 30.
Artigo
Inglês
| MEDLINE | ID: mdl-37647630
13.
Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins.
Toxicol In Vitro
; 46: 29-38, 2018 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-28919358
14.
Model-based identification of TNFα-induced IKKß-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.
NPJ Syst Biol Appl
; 4: 23, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-29900006
15.
Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study.
Toxicol Sci
; 162(2): 655-666, 2018 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29329425
16.
Donor-Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells.
Stem Cells Transl Med
; 6(5): 1321-1331, 2017 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28456008
17.
Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats.
Toxicol Lett
; 258: 207-215, 2016 Sep 06.
Artigo
Inglês
| MEDLINE | ID: mdl-27363785
18.
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.
Sci Rep
; 6: 25187, 2016 05 04.
Artigo
Inglês
| MEDLINE | ID: mdl-27143246
19.
Glutathione metabolism in the HaCaT cell line as a model for the detoxification of the model sensitisers 2,4-dinitrohalobenzenes in human skin.
Toxicol Lett
; 237(1): 11-20, 2015 Aug 19.
Artigo
Inglês
| MEDLINE | ID: mdl-26022718
20.
Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication.
Toxicol Sci
; 147(2): 412-24, 2015 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-26160117