Detalhe da pesquisa
1.
Emerging applications of genome-editing technology to examine functionality of GWAS-associated variants for complex traits.
Physiol Genomics
; 50(7): 510-522, 2018 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29652634
2.
Identifying functional noncoding variants from genome-wide association studies for cardiovascular disease and related traits.
Curr Opin Lipidol
; 26(2): 120-6, 2015 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-25692342
3.
Use of allele-specific FAIRE to determine functional regulatory polymorphism using large-scale genotyping arrays.
PLoS Genet
; 8(8): e1002908, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22916038
4.
Interleukin-6 receptor pathways in abdominal aortic aneurysm.
Eur Heart J
; 34(48): 3707-16, 2013 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-23111417
5.
The Genetics of Coronary Artery Disease: A Vascular Perspective.
Cells
; 12(18)2023 Sep 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37759455
6.
Application of statistical and functional methodologies for the investigation of genetic determinants of coronary heart disease biomarkers: lipoprotein lipase genotype and plasma triglycerides as an exemplar.
Hum Mol Genet
; 19(20): 3936-47, 2010 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20650961
7.
The functional interaction on in vitro gene expression of APOA5 SNPs, defining haplotype APOA52, and their paradoxical association with plasma triglyceride but not plasma apoAV levels.
Biochim Biophys Acta
; 1782(7-8): 447-52, 2008.
Artigo
Inglês
| MEDLINE | ID: mdl-18395529
8.
A functional mutation in the LDLR promoter (-139C>G) in a patient with familial hypercholesterolemia.
Eur J Hum Genet
; 15(11): 1186-9, 2007 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-17625505
9.
Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22.
Dis Markers
; 2017: 1096916, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28458444
10.
Post-GWAS methodologies for localisation of functional non-coding variants: ANGPTL3.
Atherosclerosis
; 246: 193-201, 2016 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-26800306
11.
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
Nat Genet
; 48(10): 1171-1184, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27618452
12.
Demonstration of the presence of the "deleted" MIR122 gene in HepG2 cells.
PLoS One
; 10(3): e0122471, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25811611
13.
Functional Analysis of a Carotid Intima-Media Thickness Locus Implicates BCAR1 and Suggests a Causal Variant.
Circ Cardiovasc Genet
; 8(5): 696-706, 2015 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-26276885
14.
A genome-wide association study identifies multiple loci for variation in human ear morphology.
Nat Commun
; 6: 7500, 2015 Jun 24.
Artigo
Inglês
| MEDLINE | ID: mdl-26105758
15.
Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels.
Circ Cardiovasc Genet
; 7(2): 144-50, 2014 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-24563418
16.
Characterization of DNA-binding proteins using multiplexed competitor EMSA.
J Mol Biol
; 385(3): 714-7, 2009 Jan 23.
Artigo
Inglês
| MEDLINE | ID: mdl-19059416
17.
Cytokine and cytokine receptor gene polymorphisms and their functionality.
Cytokine Growth Factor Rev
; 20(1): 43-59, 2009 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-19038572
18.
Association of serum interleukin-6 concentration with a functional IL6 -6331T>C polymorphism.
Clin Chem
; 54(5): 841-50, 2008 May.
Artigo
Inglês
| MEDLINE | ID: mdl-18356242
19.
Accuracy of haplotype association studies is enhanced by increasing number of polymorphic loci examined: comment on the article by Meulenbelt et al.
Arthritis Rheum
; 52(2): 675; author reply 675-6, 2005 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-15692964