Detalhe da pesquisa
1.
A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
J Biol Chem
; 291(3): 1267-76, 2016 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26515064
2.
Pyroglutamate and O-linked glycan determine functional production of anti-IL17A and anti-IL22 peptide-antibody bispecific genetic fusions.
J Biol Chem
; 288(2): 1409-19, 2013 Jan 11.
Artigo
Inglês
| MEDLINE | ID: mdl-23184956
3.
Engineering novel Lec1 glycosylation mutants in CHO-DUKX cells: molecular insights and effector modulation of N-acetylglucosaminyltransferase I.
Biotechnol Bioeng
; 109(7): 1723-34, 2012 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-22252477
4.
Large-Scale Transient Production in ExpiCHO-S™ with Enhanced N-Galactosylation-Sialylation and PEI-Based Transfection.
Methods Mol Biol
; 2313: 143-150, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-34478135
5.
Cysteine metabolic engineering and selective disulfide reduction produce superior antibody-drug-conjugates.
Sci Rep
; 12(1): 7262, 2022 05 04.
Artigo
Inglês
| MEDLINE | ID: mdl-35508689
6.
Transient CHO expression platform for robust antibody production and its enhanced N-glycan sialylation on therapeutic glycoproteins.
Biotechnol Prog
; 35(1): e2724, 2019 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30299005
7.
Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.
Neuron
; 41(4): 587-98, 2004 Feb 19.
Artigo
Inglês
| MEDLINE | ID: mdl-14980207
8.
Expression, purification and crystallization of the ecto-enzymatic domain of rat E-NTPDase1 CD39.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 64(Pt 11): 1063-5, 2008 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18997343
9.
Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing.
Sci Rep
; 8(1): 4241, 2018 03 09.
Artigo
Inglês
| MEDLINE | ID: mdl-29523796
10.
Mechanistic understanding of the cysteine capping modifications of antibodies enables selective chemical engineering in live mammalian cells.
J Biotechnol
; 248: 48-58, 2017 Apr 20.
Artigo
Inglês
| MEDLINE | ID: mdl-28300660
11.
Improved variants of SrtA for site-specific conjugation on antibodies and proteins with high efficiency.
Sci Rep
; 6: 31899, 2016 08 18.
Artigo
Inglês
| MEDLINE | ID: mdl-27534437
12.
CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.
MAbs
; 5(6): 882-95, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23995618
13.
Swift residue-screening identifies key N-glycosylated asparagines sufficient for surface expression of neuroglycoprotein Lingo-1.
FEBS Lett
; 583(6): 1034-8, 2009 Mar 18.
Artigo
Inglês
| MEDLINE | ID: mdl-19254717
14.
Automated systems for protein crystallization.
Methods
; 34(3): 329-47, 2004 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-15325651