Detalhe da pesquisa
1.
Mechanisms and regulation of cholesterol homeostasis.
Nat Rev Mol Cell Biol
; 21(4): 225-245, 2020 04.
Artigo
Inglês
| MEDLINE | ID: mdl-31848472
2.
Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts.
Cell
; 184(1): 289, 2021 Jan 07.
Artigo
Inglês
| MEDLINE | ID: mdl-33417863
3.
Cholesterol transport through lysosome-peroxisome membrane contacts.
Cell
; 161(2): 291-306, 2015 Apr 09.
Artigo
Inglês
| MEDLINE | ID: mdl-25860611
4.
The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity.
Nat Immunol
; 18(5): 519-529, 2017 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28346409
5.
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.
Nature
; 608(7922): 413-420, 2022 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35922515
6.
GRAMD1/ASTER-mediated cholesterol transport promotes Smoothened cholesterylation at the endoplasmic reticulum.
EMBO J
; 42(3): e111513, 2023 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36524353
7.
Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages.
Immunity
; 49(5): 842-856.e7, 2018 11 20.
Artigo
Inglês
| MEDLINE | ID: mdl-30366764
8.
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
Nature
; 588(7838): 479-484, 2020 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33177714
9.
Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.
Mol Cell
; 66(1): 154-162.e10, 2017 Apr 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28344083
10.
EZH2 W113C is a gain-of-function mutation in B-cell lymphoma enabling both PRC2 methyltransferase activation and tazemetostat resistance.
J Biol Chem
; 299(4): 103073, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36858198
11.
New Loss-of-Function Mutations in PCSK9 Reduce Plasma LDL Cholesterol.
Arterioscler Thromb Vasc Biol
; 43(7): 1219-1233, 2023 07.
Artigo
Inglês
| MEDLINE | ID: mdl-37165876
12.
Intracellular Cholesterol Transport by Sterol Transfer Proteins at Membrane Contact Sites.
Trends Biochem Sci
; 44(3): 273-292, 2019 03.
Artigo
Inglês
| MEDLINE | ID: mdl-30415968
13.
TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport.
J Lipid Res
; 64(12): 100465, 2023 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37890669
14.
Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis.
Circulation
; 145(9): 675-687, 2022 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35189703
15.
Discovery of an insulin-induced gene binding compound that ameliorates nonalcoholic steatohepatitis by inhibiting sterol regulatory element-binding protein-mediated lipogenesis.
Hepatology
; 76(5): 1466-1481, 2022 11.
Artigo
Inglês
| MEDLINE | ID: mdl-35102596
16.
Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease.
PLoS Genet
; 16(8): e1008955, 2020 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32776921
17.
SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1.
J Biol Chem
; 296: 100032, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-33154164
18.
Deficiency of Histone Methyltransferase SET Domain-Containing 2 in Liver Leads to Abnormal Lipid Metabolism and HCC.
Hepatology
; 73(5): 1797-1815, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33058300
19.
Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism.
Nature
; 531(7596): 651-5, 2016 Mar 31.
Artigo
Inglês
| MEDLINE | ID: mdl-26982734
20.
The cation-π interaction in cysteine-rich domain of Smoothened is critical for its cholesterylation and function.
Acta Biochim Biophys Sin (Shanghai)
; 54(8): 1171-1179, 2022 Aug 25.
Artigo
Inglês
| MEDLINE | ID: mdl-35904215