Detalhe da pesquisa
1.
Insights into cytokine-receptor interactions from cytokine engineering.
Annu Rev Immunol
; 33: 139-67, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25493332
2.
Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.
Cell
; 184(4): 983-999.e24, 2021 02 18.
Artigo
Inglês
| MEDLINE | ID: mdl-33606986
3.
Engineering the IL-4/IL-13 axis for targeted immune modulation.
Immunol Rev
; 320(1): 29-57, 2023 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-37283511
4.
Engineering Anticytokine Antibodies for Immune Modulation.
J Immunol
; 212(2): 225-234, 2024 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38166248
5.
Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds.
Nat Chem Biol
; 19(9): 1127-1137, 2023 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37024727
6.
De novo design of potent and selective mimics of IL-2 and IL-15.
Nature
; 565(7738): 186-191, 2019 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30626941
7.
Redirecting the specificity of tripartite motif containing-21 scaffolds using a novel discovery and design approach.
J Biol Chem
; 299(12): 105381, 2023 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-37866632
8.
Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.
Immunity
; 42(5): 815-25, 2015 May 19.
Artigo
Inglês
| MEDLINE | ID: mdl-25992858
9.
Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.
Immunity
; 42(5): 826-38, 2015 May 19.
Artigo
Inglês
| MEDLINE | ID: mdl-25992859
10.
Pharmacodynamic measures within tumors expose differential activity of PD(L)-1 antibody therapeutics.
Proc Natl Acad Sci U S A
; 118(37)2021 09 14.
Artigo
Inglês
| MEDLINE | ID: mdl-34508005
11.
Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease.
J Autoimmun
; 140: 103125, 2023 Oct 14.
Artigo
Inglês
| MEDLINE | ID: mdl-37844543
12.
Engineered bispecific antibodies targeting the interleukin-6 and -8 receptors potently inhibit cancer cell migration and tumor metastasis.
Mol Ther
; 30(11): 3430-3449, 2022 11 02.
Artigo
Inglês
| MEDLINE | ID: mdl-35841152
13.
Empowering gene delivery with protein engineering platforms.
Gene Ther
; 2022 Dec 19.
Artigo
Inglês
| MEDLINE | ID: mdl-36529795
14.
Antibody-Invertase Fusion Protein Enables Quantitative Detection of SARS-CoV-2 Antibodies Using Widely Available Glucometers.
J Am Chem Soc
; 144(25): 11226-11237, 2022 06 29.
Artigo
Inglês
| MEDLINE | ID: mdl-35675509
15.
Weaponizing T-cell receptors through molecular engineering.
J Biol Chem
; 294(15): 5805-5806, 2019 04 12.
Artigo
Inglês
| MEDLINE | ID: mdl-30979848
16.
A strategy for the selection of monovalent antibodies that span protein dimer interfaces.
J Biol Chem
; 294(38): 13876-13886, 2019 09 20.
Artigo
Inglês
| MEDLINE | ID: mdl-31387945
17.
Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy.
J Immunol
; 201(7): 2094-2106, 2018 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30104245
18.
Joined at the hip: The role of light chain complementarity determining region 2 in antibody self-association.
Proc Natl Acad Sci U S A
; 119(28): e2208330119, 2022 07 12.
Artigo
Inglês
| MEDLINE | ID: mdl-35776537
19.
Structural Basis for Signaling Through Shared Common γ Chain Cytokines.
Adv Exp Med Biol
; 1172: 1-19, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31628649
20.
Full speed AHEAD in antibody discovery.
Nat Chem Biol
; 17(10): 1011-1012, 2021 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34211163