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Braz J Biol ; 70(2): 443-9, 2010 May.
Artigo em Inglês | MEDLINE | ID: mdl-20549071

RESUMO

Molecular plant components have long been aimed at the angiogenesis and anti-angiogenesis pathways, and have been tested as sources for antineoplasic drugs with promising success. The present work deals with the anti-angiogenic effects of Methyl Jasmonate. Jasmonate derivatives were demonstrated to selectively damage the mitochondria of cancer cells. In vitro, 1-10 mM Methyl Jasmonate induced the cell death of the human umbilical vein endothelial cells (HUVEC) and the Murine melanoma cells (B16F10), while micromolar concentrations were ineffective. In vivo, comparable concentrations were toxic and reduced the vessel density of the Chorioallantoic Membrane of the Chicken Embryo (CAM). However, 1-10 microM concentrations produced a complex effect. There was increased capillary budding, but the new vessels were leakier and less organised than corresponding controls. It is suggested that not only direct toxicity, but also the drug effects upon angiogenesis are relevant to the antineoplasic effects of Methyl Jasmonate.


Assuntos
Acetatos/farmacologia , Inibidores da Angiogênese/farmacologia , Antineoplásicos/farmacologia , Membrana Corioalantoide/efeitos dos fármacos , Ciclopentanos/farmacologia , Células Endoteliais/efeitos dos fármacos , Oxilipinas/farmacologia , Animais , Linhagem Celular Tumoral , Embrião de Galinha , Membrana Corioalantoide/irrigação sanguínea , Células Endoteliais/citologia , Humanos , Veias Umbilicais/citologia , Veias Umbilicais/efeitos dos fármacos
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