Detalhe da pesquisa
1.
Phase I open label liver-directed gene therapy clinical trial for acute intermittent porphyria.
J Hepatol
; 65(4): 776-783, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27212246
2.
Sustained enzymatic correction by rAAV-mediated liver gene therapy protects against induced motor neuropathy in acute porphyria mice.
Mol Ther
; 19(2): 243-50, 2011 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-20877347
3.
AAV gene therapy as a means to increase apolipoprotein (Apo) A-I and high-density lipoprotein-cholesterol levels: correction of murine ApoA-I deficiency.
J Gene Med
; 11(8): 697-707, 2009 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-19431216
4.
AAV1-LPL(S447X) gene therapy reduces hypertriglyceridemia in apoE2 knock in mice.
Biochim Biophys Acta
; 1761(10): 1163-8, 2006 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-16990047
5.
Gene therapy in disorders of lipoprotein metabolism.
Curr Gene Ther
; 7(1): 35-47, 2007 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-17305527
6.
Correction of feline lipoprotein lipase deficiency with adeno-associated virus serotype 1-mediated gene transfer of the lipoprotein lipase S447X beneficial mutation.
Hum Gene Ther
; 17(5): 487-99, 2006 May.
Artigo
Inglês
| MEDLINE | ID: mdl-16716106
7.
Aorta of ApoE-deficient mice responds to atherogenic stimuli by a prelesional increase and subsequent decrease in the expression of antioxidant enzymes.
Circ Res
; 93(3): 262-9, 2003 Aug 08.
Artigo
Inglês
| MEDLINE | ID: mdl-12829615
8.
Complete rescue of lipoprotein lipase-deficient mice by somatic gene transfer of the naturally occurring LPLS447X beneficial mutation.
Arterioscler Thromb Vasc Biol
; 25(10): 2143-50, 2005 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-16002740
9.
Gene therapy for lipoprotein lipase deficiency: working toward clinical application.
Hum Gene Ther
; 16(11): 1276-86, 2005 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-16259561
10.
Transplantation of monocyte CC-chemokine receptor 2-deficient bone marrow into ApoE3-Leiden mice inhibits atherogenesis.
Arterioscler Thromb Vasc Biol
; 23(3): 447-53, 2003 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-12615695
11.
Long-term correction of murine lipoprotein lipase deficiency with AAV1-mediated gene transfer of the naturally occurring LPL(S447X) beneficial mutation.
Hum Gene Ther
; 15(9): 906-19, 2004 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-15353045
12.
P-selectin as a candidate target in atherosclerosis.
Biochem Pharmacol
; 66(5): 859-66, 2003 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-12948867
13.
Intramuscular administration of AAV1-lipoprotein lipase S447X lowers triglycerides in lipoprotein lipase-deficient patients.
Arterioscler Thromb Vasc Biol
; 28(12): 2303-4, 2008 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-18802015
14.
Immune responses to intramuscular administration of alipogene tiparvovec (AAV1-LPL(S447X)) in a phase II clinical trial of lipoprotein lipase deficiency gene therapy.
Hum Gene Ther
; 25(3): 180-8, 2014 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-24299335
15.
Effect of alipogene tiparvovec (AAV1-LPL(S447X)) on postprandial chylomicron metabolism in lipoprotein lipase-deficient patients.
J Clin Endocrinol Metab
; 97(5): 1635-44, 2012 May.
Artigo
Inglês
| MEDLINE | ID: mdl-22438229
16.
Adeno-associated viral vector (AAV)-mediated gene transfer in the red nucleus of the adult rat brain: comparative analysis of the transduction properties of seven AAV serotypes and lentiviral vectors.
J Neurosci Methods
; 185(2): 257-63, 2010 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19850079
17.
Effect of adeno-associated virus serotype and genomic structure on liver transduction and biodistribution in mice of both genders.
Hum Gene Ther
; 20(8): 908-17, 2009 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-19419275
18.
Adeno-associated virus LPL(S447X) gene therapy in LDL receptor knockout mice.
Atherosclerosis
; 194(1): 55-61, 2007 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-17087965
19.
Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats.
Mol Ther
; 13(6): 1085-92, 2006 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-16581301
20.
Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice.
J Lipid Res
; 45(11): 2088-95, 2004 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-15314100