Detalhe da pesquisa
1.
Brevilin A is a potent anti-metastatic CRC agent that targets the VEGF-IL6-STAT3 axis in the HSCs-CRC interplay.
J Transl Med
; 21(1): 260, 2023 04 16.
Artigo
Inglês
| MEDLINE | ID: mdl-37062842
2.
Omics approach to reveal the effects of obesity on the protein profiles of the exosomes derived from different adipose depots.
Cell Mol Life Sci
; 79(11): 570, 2022 Oct 28.
Artigo
Inglês
| MEDLINE | ID: mdl-36306016
3.
Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra-Sensitive Immunoaffinity 2D-LC-MS/MS Approach.
Anal Chem
; 94(37): 12927-12933, 2022 09 20.
Artigo
Inglês
| MEDLINE | ID: mdl-36083155
4.
Absorption, Distribution, Metabolism, and Excretion of Therapeutic Proteins: Current Industry Practices and Future Perspectives.
Drug Metab Dispos
; 50(6): 837-845, 2022 06.
Artigo
Inglês
| MEDLINE | ID: mdl-35149541
5.
A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation.
Drug Metab Dispos
; 50(6): 846-857, 2022 06.
Artigo
Inglês
| MEDLINE | ID: mdl-35306476
6.
The impact of obesity on adipocyte-derived extracellular vesicles.
Cell Mol Life Sci
; 78(23): 7275-7288, 2021 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-34677643
7.
Automated, Generic Reagent and Ultratargeted 2D-LC-MS/MS Enabling Quantification of Biotherapeutics and Soluble Targets down to pg/mL Range in Serum.
Anal Chem
; 92(13): 9412-9420, 2020 07 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32510921
8.
Protein Biomarker Quantification by Immunoaffinity Liquid Chromatography-Tandem Mass Spectrometry: Current State and Future Vision.
Clin Chem
; 66(2): 282-301, 2020 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32040572
9.
Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).
Bioorg Med Chem Lett
; 30(4): 126907, 2020 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31902710
10.
Role of identified noncoding RNA in erectile dysfunction.
Andrologia
; 52(7): e13596, 2020 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-32441367
11.
Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo.
Bioconjug Chem
; 30(5): 1356-1370, 2019 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30966735
12.
Role of identified RNA N6-methyladenosine methylation in liver.
Anal Biochem
; 578: 45-50, 2019 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31075230
13.
Modulating Antibody-Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification.
Bioconjug Chem
; 29(4): 1155-1167, 2018 04 18.
Artigo
Inglês
| MEDLINE | ID: mdl-29481745
14.
Conjugation of Indoles to Antibodies through a Novel Self-Immolating Linker.
Chemistry
; 24(19): 4830-4834, 2018 Apr 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29493023
15.
Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody-Drug Conjugates.
Mol Pharm
; 15(9): 3979-3996, 2018 09 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30040421
16.
High-Resolution Accurate-Mass Mass Spectrometry Enabling In-Depth Characterization of in Vivo Biotransformations for Intact Antibody-Drug Conjugates.
Anal Chem
; 89(10): 5476-5483, 2017 05 16.
Artigo
Inglês
| MEDLINE | ID: mdl-28429938
17.
Attachment Site Cysteine Thiol pKa Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody-Drug Conjugates.
Bioconjug Chem
; 28(10): 2538-2548, 2017 10 18.
Artigo
Inglês
| MEDLINE | ID: mdl-28885827
18.
Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates.
Bioconjug Chem
; 28(8): 2086-2098, 2017 08 16.
Artigo
Inglês
| MEDLINE | ID: mdl-28636382
19.
Custom-Designed Affinity Capture LC-MS F(ab')2 Assay for Biotransformation Assessment of Site-Specific Antibody Drug Conjugates.
Anal Chem
; 88(23): 11340-11346, 2016 12 06.
Artigo
Inglês
| MEDLINE | ID: mdl-27779866
20.
Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates.
Drug Metab Dispos
; 44(9): 1517-23, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27417182