Detalhe da pesquisa
1.
Quantitative Translational Analysis of Brain Kynurenic Acid Modulation via Irreversible Kynurenine Aminotransferase II Inhibition.
Mol Pharmacol
; 94(2): 823-833, 2018 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29853495
2.
PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency.
Bioorg Med Chem Lett
; 23(7): 1961-6, 2013 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23466229
3.
Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.
Biochem J
; 444(1): 79-88, 2012 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22397330
4.
Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.
Proc Natl Acad Sci U S A
; 107(34): 15240-5, 2010 Aug 24.
Artigo
Inglês
| MEDLINE | ID: mdl-20696890
5.
Identification of an inhibitor of the MurC enzyme, which catalyzes an essential step in the peptidoglycan precursor synthesis pathway.
Assay Drug Dev Technol
; 6(1): 95-103, 2008 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-18315498
6.
GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like.
J Med Chem
; 61(20): 9301-9315, 2018 10 25.
Artigo
Inglês
| MEDLINE | ID: mdl-30289257
7.
Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.
J Med Chem
; 59(11): 5391-402, 2016 06 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27219867
8.
Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions.
ACS Med Chem Lett
; 4(1): 37-40, 2013 Jan 10.
Artigo
Inglês
| MEDLINE | ID: mdl-24900560
9.
Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.
ACS Med Chem Lett
; 3(3): 187-92, 2012 Mar 08.
Artigo
Inglês
| MEDLINE | ID: mdl-24900455
10.
Decrypting the biochemical function of an essential gene from Streptococcus pneumoniae using ThermoFluor technology.
J Biol Chem
; 280(12): 11704-12, 2005 Mar 25.
Artigo
Inglês
| MEDLINE | ID: mdl-15634672
11.
Targeting the MraY and MurG bacterial enzymes for antimicrobial therapeutic intervention.
Anal Biochem
; 314(2): 243-52, 2003 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-12654311