Detalhe da pesquisa
1.
Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung.
Nature
; 528(7580): 127-31, 2015 Dec 03.
Artigo
Inglês
| MEDLINE | ID: mdl-26580007
2.
Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J Biol Chem
; 293(43): 16803-16817, 2018 10 26.
Artigo
Inglês
| MEDLINE | ID: mdl-30206119
3.
Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300.
Bioorg Med Chem Lett
; 28(1): 15-23, 2018 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29169673
4.
Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists.
Bioorg Med Chem Lett
; 24(16): 3891-7, 2014 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25017032
5.
A reversed sulfonamide series of selective RORc inverse agonists.
Bioorg Med Chem Lett
; 24(24): 5769-5776, 2014 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25453817
6.
Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.
Bioorg Med Chem Lett
; 23(24): 6604-9, 2013 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24239186
7.
Antibody interfaces revealed through structural mining.
Comput Struct Biotechnol J
; 20: 4952-4968, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36147680
8.
Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members.
MAbs
; 11(6): 996-1011, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31156033
9.
A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors.
J Med Chem
; 60(24): 10151-10171, 2017 12 28.
Artigo
Inglês
| MEDLINE | ID: mdl-29155580
10.
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J Med Chem
; 60(22): 9162-9183, 2017 11 22.
Artigo
Inglês
| MEDLINE | ID: mdl-28892380
11.
Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J Med Chem
; 59(23): 10549-10563, 2016 12 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27682507
12.
Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).
ACS Med Chem Lett
; 7(5): 531-6, 2016 May 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27190605
13.
The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site.
Structure
; 20(10): 1704-14, 2012 Oct 10.
Artigo
Inglês
| MEDLINE | ID: mdl-22921830