An autosomal recessive variant in PYGM causes myophosphorylase deficiency in Red Angus composite cattle.

BACKGROUND: Between 2020 and 2022, eight calves in a Nebraska herd (composite Simmental, Red Angus, Gelbvieh) displayed exercise intolerance during forced activity. In some cases, the calves collapsed and did not recover. Available sire pedigrees contained a paternal ancestor within 2-4 generations in all affected calves. Pedigrees of the calves' dams were unavailable, however, the cows were ranch-raised and retained from prior breeding seasons, where bulls used for breeding occasionally had a common ancestor. Therefore, it was hypothesized that a de novo autosomal recessive variant was causative of exercise intolerance in these calves. RESULTS: A genome-wide association analysis utilizing SNP data from 6 affected calves and 715 herd mates, followed by whole-genome sequencing of 2 affected calves led to the identification of a variant in the gene PYGM (BTA29:g.42989581G > A). The variant, confirmed to be present in the skeletal muscle transcriptome, was predicted to produce a premature stop codon (p.Arg650*). The protein product of PYGM, myophosphorylase, breaks down glycogen in skeletal muscle. Glycogen concentrations were fluorometrically assayed as glucose residues demonstrating significantly elevated glycogen concentrations in affected calves compared to cattle carrying the variant and to wild-type controls. The absence of the PYGM protein product in skeletal muscle was confirmed by immunohistochemistry and label-free quantitative proteomics analysis; muscle degeneration was confirmed in biopsy and necropsy samples. Elevated skeletal muscle glycogen persisted after harvest, resulting in a high pH and dark-cutting beef, which is negatively perceived by consumers and results in an economic loss to the industry. Carriers of the variant did not exhibit differences in meat quality or any measures of animal well-being. CONCLUSIONS: Myophosphorylase deficiency poses welfare concerns for affected animals and negatively impacts the final product. The association of the recessive genotype with dark-cutting beef further demonstrates the importance of genetics to not only animal health but to the quality of their product. Although cattle heterozygous for the variant may not immediately affect the beef industry, identifying carriers will enable selection and breeding strategies to prevent the production of affected calves.

Cattle production strategies to deliver protein with less land and lower environmental impact.

Global land resources are over-exploited and natural habitats are declining, often driven by expanding livestock production. In Ireland, pastureland for grazing cattle and sheep account for circa 60% of terrestrial land use. The agriculture, forestry and other land use sector (AFOLU) is responsible for 44% of national greenhouse gas (GHG) emissions. A new Grassland Animal response Model (GLAM) was developed to relate livestock-cohort grass and feed requirements to farm-grassland system areas, enhancing environmental assessment of prospective AFOLU configurations. Although land conversion targets are often well-defined, they tend to lack a clear definition of where land sparing can occur. Through analyses of 10 scenarios of milk and beef production and management strategies, we found that displacing beef cows with dairy cows can increase national protein output while sparing up to 0.75 million ha (18%) of grassland (albeit with a minor increase in overseas land requirement for additional concentrate feed). Reducing slaughter age, increasing exports of male dairy calves and increasing grassland use efficiency on beef farms each achieved between 0.19 and 0.32 million ha of land sparing. Sexed semen to achieve more favourable male-female birth ratios had a minor impact. GHG emissions, ammonia emissions and nutrient leaching were only reduced substantially when overall cattle numbers declined, confirming the need for cattle reductions to achieve environmental objectives. Nonetheless, application of GLAM shows potential for improved grass and cattle management to spare good quality land suitable for productive forestry and wetland restoration. This change is urgently needed to generate scalable carbon dioxide removals from the land sector in Ireland, and globally.

A review of mitigation technologies and management strategies for greenhouse gas and air pollutant emissions in livestock production.

One of the key issues in manure management of livestock production is to reduce greenhouse gas (GHG) and air pollutant emissions, which lead to significant environmental footprint and human/animal health threats. This study provides a review of potentially efficacious technologies and management strategies that reduce GHG and air pollutant emissions during the three key stages of manure management in livestock production, i.e., animal housing, manure storage and treatment, and manure application. Several effective mitigation technologies and practices for each manure management stage are identified and analyzed in detail, including feeding formulation adjustment, frequent manure removal and air scrubber during animal housing stage; solid-liquid separation, manure covers for storage, acidification, anaerobic digestion and composting during manure storage and treatment stage; land application techniques at appropriate timing during manure application stage. The results indicated several promising approaches to reduce multiple gas emissions from the entire manure management. Removing manure 2-3 times per week or every day during animal housing stage is an effective and simple way to reduce GHG and air pollutant emissions. Acidification during manure storage and treatment stage can reduce ammonia and methane emissions by 33%-93% and 67%-87%, respectively and proper acid, such as lactic acid can also reduce nitrous oxide emission by about 90%. Shallow injection of manure for field application has the best performance in reducing ammonia emission by 62%-70% but increase nitrous oxide emission. The possible trade-off brings insight to the prioritization of targeted gas emissions for the researchers, stakeholders and policymakers, and also highlights the importance of assessing the mitigation technologies across the entire manure management chain. Implementing a combination of the management strategies needs comprehensive considerations about mitigation efficiency, technical feasibility, local regulations, climate condition, scalability and cost-effectiveness.

Control of odor emissions from livestock farms: A review.

Odor emission seriously affects human and animal health, and the ecological environment. Nevertheless, a systematic summary regarding the control technology for odor emissions in livestock breeding is currently lacking. This paper summarizes odor control technology, highlighting its applicability, advantages, and limitations, which can be used to evaluate and identify the most appropriate methods in livestock production management. Odor control technologies are divided into four categories: dietary manipulation (low-crude protein diet and enzyme additives in feed), in-housing management (separation of urine from feces, adsorbents used as litter additive, and indoor environment/manure surface spraying agent), manure management (semi-permeable membrane-covered, reactor composting, slurry cover, and slurry acidification), and end-of-pipe measures for air treatment (wet scrubbing of the exhaust air from animal houses and biofiltration of the exhaust air from animal houses or composting). Findings of this paper provide a theoretical basis for the application of odor control technology in livestock farms.

Artificial Intelligence and Sensor Technologies in Dairy Livestock Export: Charting a Digital Transformation.

This technical note critically evaluates the transformative potential of Artificial Intelligence (AI) and sensor technologies in the swiftly evolving dairy livestock export industry. We focus on the novel application of the Internet of Things (IoT) in long-distance livestock transportation, particularly in livestock enumeration and identification for precise traceability. Technological advancements in identifying behavioral patterns in 'shy feeder' cows and real-time weight monitoring enhance the accuracy of long-haul livestock transportation. These innovations offer benefits such as improved animal welfare standards, reduced supply chain inaccuracies, and increased operational productivity, expanding market access and enhancing global competitiveness. However, these technologies present challenges, including individual animal customization, economic analysis, data security, privacy, technological adaptability, training, stakeholder engagement, and sustainability concerns. These challenges intertwine with broader ethical considerations around animal treatment, data misuse, and the environmental impacts. By providing a strategic framework for successful technology integration, we emphasize the importance of continuous adaptation and learning. This note underscores the potential of AI, IoT, and sensor technologies to shape the future of the dairy livestock export industry, contributing to a more sustainable and efficient global dairy sector.

Costs and effects of measures to reduce ammonia emissions from dairy cattle and pig production: A comparison of country-specific estimations and model calculations.

Understanding the costs of emission abatement measures is essential for devising reduction efforts. It allows to identify cost-effective solutions to achieve target values set by international agreements or national policies. This work aims to summarize and discuss the current knowledge on costs and effects associated with selected ammonia (NH3) mitigation measures in livestock production through comparison of country-specific and model-estimated values. Often, large differences appear between the results of individual countries, also in comparison with model results that are generally better harmonized between countries. It seems that different system boundaries in cost assessments, but also different geographic and structural conditions create perceived as well as real cost differences, also caused by the variability of individual situations. Our results are robust with respect to identifying feeding strategies as the most cost-effective, but results for other mitigation options do not show any clear trends, thus making it difficult to distinguish further cost-effective solutions. We point out and discuss some key aspects which may affect estimates of national costs, leading to challenges with the interpretation of final results. Our study concludes that further and more consistent assessments (e.g. standardized protocols) are needed to improve the evaluation base for other individual abatement options, including options that are under development.

Nitrogen in the Yangtze River Basin: Pollution Reduction through Coupling Crop and Livestock Production.

Livestock production poses a threat to water quality worldwide. A better understanding of the contribution of individual livestock species to nitrogen (N) pollution in rivers is essential to improve water quality. This paper aims to quantify inputs of dissolved inorganic nitrogen (DIN) to the Yangtze River from different livestock species at multiple scales and explore ways for reducing these inputs through coupling crop and livestock production. We extended the previously developed model MARINA (Model to Assess River Input of Nutrient to seAs) with the NUFER (Nutrient flows in Food chains, Environment, and Resource use) approach for livestock. Results show that DIN inputs to the Yangtze River vary across basins, sub-basins, and 0.5° grids, as well as across livestock species. In 2012, livestock production resulted in 2000 Gg of DIN inputs to the Yangtze River. Pig production was responsible for 55-85% of manure-related DIN inputs. Rivers in the downstream sub-basin received higher manure-related DIN inputs than rivers in the other sub-basins. Around 20% of the Yangtze basin is considered as a manure-related hotspot of river pollution. Recycling manure on cropland can avoid direct discharges of manure from pig production and thus reduce river pollution. The potential for recycling manure is larger in cereal production than in other crop species. Our results can help to identify effective solutions for coupling crop and livestock production in the Yangtze basin.

Ecological thresholds of toxic plants for sheep production and ecosystem multifunctionality and their trade-off in an alpine meadow.

Toxic plants are a natural component of alpine meadow which co-evolved with Tibetan sheep for thousands of years. One challenge for indigenous herders is to know the ecological thresholds of toxic plants and maintain their vital functions in ways that are compatible with economic income and ecological conservation. To achieve this, field trials with Tibetan sheep grazing in alpine meadow were conducted to examine the ecological thresholds of toxic plants for sheep production and ecosystem functions and their trade-offs. Our results demonstrated that the changing point values of biomass proportion of toxic plants for dry matter intake and liveweight gain of sheep were 17% and 22%, respectively. The changing point value of biomass (richness) proportion of toxic plants for soil carbon accumulation index was 31% (59%), for soil nutrient cycling index was 38% (42%), and for ecosystem multifunctionality index was 28% (50%). The trade-off between liveweight gain of sheep and ecosystem multifunctionality first decreased and then increased along the gradient of biomass proportion of toxic plants (the value of changing point was 37%), and had a significant negative correlation with richness of toxic plants. In addition, structural equation modeling indicated that toxic plants can affect the trade-off between liveweight gain of sheep and ecosystem multifunctionality though increasing acid detergent fiber of plant and decreasing plant species richness, belowground biomass and soil total phosphorus. Consequently, opinions towards toxic plants should shift from the conventional view that they are serious threat to grassland ecosystem health to an inclusive understanding that they are beneficial to livestock and ecosystem functions under certain ecological thresholds.

Global pastureland use as reflected in inter-regional supply chain.

Pastureland used for livestock grazing is globally much bigger than arable land. This study investigates the pastureland use embedded in global supply chains by using multi-regional systems input-output anlysis, tracing embodied pastureland use from source of exploitation to sink of final consumption in the global economy. The world's pastureland resources is shown reallocated through the supply chain mainly to the four major economies: EU, the United States, China, and Japan. These four economies are responsible for driving more than half of the global pastureland exploitation. Major supply chains responsible for the global reallocation of pastureland use include the cattle supply chain from Other Asia & Pacific to the United States, China, and Japan, and the cattle supply chain from Africa to EU and the Middle East. This paper demonstrates the nature and scale of the global reallocation of pastureland resources through the supply chain, highlighting the fact that the global shift of pastureland use from nature-based to economic-based may exacerbate ecological inequity between world regions. It is proposed that future policies and regulations should encourage sustainability goals not only on a regional level but on a global scale, finding pathways to sustainable and equitable livestock production by inter-regional collaboration.

How light is too light touch: The effect of a short training-based intervention on household poultry production in Burkina Faso.

This paper reports on the effects of a training-based intervention seeking to increase household engagement in poultry production in Burkina Faso, analyzing data from a large-scale cluster randomized trial in which 1798 households in 60 communes were observed over a period of three years. The intervention SELEVER - entailing a short series of trainings for households as well as capacity building for local animal health and credit services - had little effect on household poultry production and no effect on profits. There is some evidence of an increase in the utilization of poultry inputs and an associated reduction in poultry mortality, primarily for larger poultry producers; however, there is no evidence of any treatment effects for the smallest producers.

Quantification of nitrogen and phosphorus inputs from farming activities into the water bodies in the Leningrad and Kaliningrad regions.

Agricultural intensification leads to higher diffuse environmental pollution. Successful pollution control requires the continuous monitoring of farming activities, reliable baseline data, and tested computational models for the quantitative assessment of diffuse loads. The study aimed to quantify the diffuse inputs of manure nitrogen (N) and phosphorus (P) to the marine environment from large livestock farms and to identify the lowering effect of the best available techniques of manure/organic fertiliser handling. The study area was the Leningrad and Kaliningrad regions, found in the Russian part of the Baltic Sea catchment area. The total diffuse load in 2017 was estimated by the Russian and Belarus methodologies based on the calculations of the livestock density and the total field application of nitrogen and phosphorus with organic fertilisers. In the Leningrad Region, it was 4571.53 t N year-1 and 280.01 t P year-1; in the Kaliningrad Region-6132.48 t N year-1 and 372.32 t P year-1. The introduction of relevant best available techniques and the supply of all farms with waterproof manure storages and pads could reduce the diffuse load on the catchment in the Leningrad region by 1078.07 t N year-1 and 55.5 t P year-1 and in the Kaliningrad Region-by 1060.43 t N year-1 and 40.5 t P year-1. Such a reduction would provide a marked contribution to fulfilling the nutrient input ceilings set for the Russian Federation under the Helsinki Commission (HELCOM) Baltic Sea Action Plan.

Animal welfare analysis: a case of smallholder farmers in Zambia.

Animal welfare remains a contemporary issue in livestock development as World Organization for Animal Health stresses its importance in the livestock trade. Key elements of good animal welfare include animals being healthy, comfortable, well-nourished, safe, not suffering from unpleasant states such as pain, fear, and distress, and expressing behaviours that are important for their physical and mental health. These are important for the high performance of animals in terms of productivity and product quality. Given the importance of animal welfare in enhancing livestock productivity, quality, food safety, and economic returns, the study aimed to identify the aspects of animal welfare that need more attention among the Zambian smallholder livestock farmers and determine whether the current policy and legal frameworks governing animal welfare are adequate. Using data collected from 271 smallholder households, the study found that routine management practices such as dipping animals, branding, castration, and vaccination were the major animal welfare concerns that needed more attention. Therefore more efforts and extension services should also be dedicated to addressing these concerns. Furthermore, the policy framework guiding animal welfare is inadequate as particular welfare concerns such as housing and nutrition are not well covered. This calls for the revision of the policy framework to incorporate all aspects of animal welfare.

Influence of COVID-19 on the sustainability of livestock performance and welfare on a global scale.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently spreading worldwide. The pandemic has already had significant adverse effects on human civilization, the environment, and the ecosystem at national and global levels. Moreover, the various sectors of the food production chain, particularly agriculture and livestock, have also been significantly affected in terms of production sustainability and economic losses. The global pandemic has already resulted in a sharp drop in meat, milk, and egg production. Restrictions of movement at national and international levels, implemented as a part of control strategies by public health sectors, have negatively impacted business related to the supply of raw materials for livestock farmers and farm outputs, veterinary services, farmworkers, and animal welfare. This review highlights the significant impacts of COVID-19 on the sustainability of livestock performance, welfare on a global scale, and strategies for mitigating these adverse effects.

Understanding vulnerability of agricultural production system to climatic stressors in North Indian Plains: a meso-analysis.

The present study has mapped the hot spots vulnerable to changing climate and identified the underlying driving indicators in subtropical Trans and Upper Gangetic plains (TUGP) of India. The long-term trends indicate that the area between latitude 25 and 28° N has been more exposed to adverse climatic changes especially rise in maximum summer/monsoon and minimum winter temperatures. The more predominant correlates of vulnerability in the region come not from the exposure to adverse meteorological conditions but from prevailing socio-economic conditions (adaptive capacity) and the increased environmental pressure (sensitivity). Among the top 40 most vulnerable districts in the TUGP, in about two-third, the exposure was at moderate to low level, but sensitivity was high and adaptive capacity very weak. Among the sensitivity indicators, the factor loadings, obtained through modified principal component technique, were high for average size of landholdings, Temperature Humidity Index load and productivity of paddy and wheat crops. Irrigation intensity, farm mechanization, cropping intensity, livestock density, proportion of milch animals stock, rural literacy rate and veterinary institutions were the critical factors in determining the adaptive capacity of a district. The study outlines range of research and policy imperatives for enhancing resilience of crop-livestock production system. Supplementary Information: The online version contains supplementary material available at 10.1007/s10668-021-01997-7.

Towards the comprehension of fasciolosis (re-)emergence: an integrative overview.

The increasing distribution and prevalence of fasciolosis in both human and livestock are concerning. Here, we examine the various types of factors influencing fasciolosis transmission and burden and the interrelations that may exist between them. We present the arsenal of molecules, 'adjusting' capabilities and parasitic strategies of Fasciola to infect. Such features define the high adaptability of Fasciola species for parasitism that facilitate their transmission. We discuss current environmental perturbations (increase of livestock and land use, climate change, introduction of alien species and biodiversity loss) in relation to fasciolosis dynamics. As Fasciola infection is directly and ultimately linked to livestock management, living conditions and cultural habits, which are also changing under the pressure of globalization and climate change, the social component of transmission is also discussed. Lastly, we examine the implication of increasing scientific and political awareness in highlighting the current circulation of fasciolosis and boosting epidemiological surveys and novel diagnostic techniques. From a joint perspective, it becomes clear that factors weight differently at each place and moment, depending on the biological, environmental, social and political interrelating contexts. Therefore, the analyses of a disease as complex as fasciolosis should be as integrative as possible to dissect the realities featuring each epidemiological scenario. Such a comprehensive appraisal is presented in this review and constitutes its main asset to serve as a fresh integrative understanding of fasciolosis.

Challenges and opportunities for quantifying greenhouse gas emissions through dairy cattle research in developing countries.

The global dairy sector is facing the challenge of reducing greenhouse gas (GHG) emissions whilst increasing productivity to feed a growing population. Despite the importance of this challenge, many developing countries do not have the required resources, specifically funding, expertise and facilities, for quantifying GHG emissions from dairy production and research. This paper aims to address this challenge by discussing the magnitude of the issue, potential mitigation approaches and benefits in quantifying GHG emissions in a developing country context. Further, the paper explores the opportunities for developing country dairy scientists to leverage resources from developed countries, such as using existing relevant GHG emission estimation models. It is clear that further research is required to support developing countries to quantify and understand GHG emissions from dairy production, as it brings significant benefits including helping to identify and implement appropriate mitigation strategies for local production systems, trading carbon credits and achieving the nationally determined contribution obligations of the Paris Agreement.

Survey on storage, application and incorporation practices for organic fertilizers in Germany.

Organic fertilizers from animal production might contain undesirable components, such as veterinary medical product (VMP) residues, that are released into the environment during application. In addition to measures to reduce the use of VMPs through animal health measures, manure management could be an expedient strategy to prevent VMPs from entering the environment. The quantity applied is mainly determined by the nitrogen content. In addition, the depth of incorporation into the soil plays a major role in the environmental risk assessment of VMPs. The new regulations of the German fertilizer ordinance (DüV, 2020), which came into force at the beginning of 2020, as well as the changes that have not yet been fully implemented, will result in adjustments to the storage, application and incorporation practices for organic fertilizer. The aim of this study was to gain more information about the practice of storage, application and incorporation and the challenges for farmers in Germany. An online survey among farmers was conducted to determine the status quo. Almost all of the 125 participants kept livestock, predominantly cattle (68%) and pigs (33%). A third of participants (30%) needed a temporary storage site, for example at neighboring farms. Of the participants, 81% (n = 125) owned cropland and/or grassland. On cropland, manure was mostly incorporated at a depth of 3-15 cm, whereas on grassland, it was mostly applied superficially. On grassland lower-emission application techniques such as slot drill or injector procedures have so far rarely been used. The survey results provided important insights about storage, application and incorporation practices for organic fertilizers in Germany which could be used for the calculation of predicted environmental concentrations (PEC) as part of the environmental risk assessments of veterinary pharmaceuticals.

Assessment of COVID-19 impacts on U.S. counties using the immediate impact model of local agricultural production (IMLAP).

CONTEXT: The COVID-19 pandemic has resulted in immediate and wide impacts on human and agricultural systems. While some of the positive and negative impacts of COVID-19 on the environment and economies are emerging, there is not a comprehensive understanding of the potential impacts of COVID-19 on the most vulnerable farmers. OBJECTIVE: The purpose of this study is to evaluate the immediate impacts of COVID-19 on agricultural and food systems in the United States. Our aim is to quantify the impacts on labor productivity in crops and livestock production considering the heterogenous vulnerability of different farmworkers. We are interested in measuring the production that is not realized due to COVID-19. METHODS: In this paper, we introduce IMLAP, Immediate impact Model of Local Agricultural Production. This model is an economic framework considering short-term agricultural production responses to economic, environmental, and policy changes. We investigate the potential impacts of COVID-19 on the farmers in the U.S. for each county with a special focus on female, Hispanic, black and African American, and small-scale producers. RESULTS AND CONCLUSIONS: Considering the impacts of COVID-19 on labor, the findings of this study suggest a decline in agricultural output in all the U.S. counties ranging from 1.18% to 7.14% of total production. Our simulation results show that counties with a higher number of small-scale farms, non-white farmers, and female-operated farms are the most vulnerable to COVID-19. Also, we argue that the stimulus policies and support packages must target these communities of producers to ensure that their livelihood is protected. The findings suggest that productivity growth (technological improvements) and international trade can eliminate the negative impacts of pandemics. SIGNIFICANCE: The proposed quantitative framework of this study is a simple yet novel model that empowers diverse research communities to provide a quick analysis of the impacts of unprecedented events. It offers a holistic framework to evaluate the response of agricultural production to changes in availability and productivity of labor, machinery & equipment, land, fertilizer, seeds, and other inputs. This study presents new foundations for agricultural research communities to provide solutions to agricultural resilience challenges and highlights the significance of demand drivers, technological growth, and international trade in strengthening the food system.

Genomics and climate change.

Climate change is predicted to change the nature and distribution of global farming systems, and strategies will be needed to adapt and optimise global food-producing systems. If genomic technologies are to be useful in this scenario, there is a need for the careful definition of phenotypes and routine sample collection, as well as large-scale genotyping of animal populations. Genomic tools will greatly enhance the characterisation of available germplasm and exploration of local genetic resources, while faster and cheaper DNA sequencing is leading to an increased understanding of the underlying genetic basis of traits. The use of genomic tools to increase animal resilience, reduce methane emissions from cattle and sheep, improve disease resistance, decrease environmental impact, reduce competition for land and water and, finally, increase production may be the most feasible path for the future of livestock production. In this review, the authors discuss various genomic strategies in the light of climate change, focusing on the selection of resistant/tolerant animals, landscape genomics, metagenomics and gene editing.

L'un des effets anticipés du changement climatique sera la modification de la nature et de la distribution des systèmes d'élevage dans le monde, raison pour laquelle des stratégies seront nécessaires pour adapter et optimiser les systèmes mondiaux de production alimentaire. Si l'on veut que les technologies de la génomique soient utiles dans ce scénario, il faudra procéder avec soin à la définition des phénotypes et à la collecte de routine des échantillons, et réaliser le génotypage à grande échelle des populations animales. Les outils génomiques permettront d'améliorer nettement la caractérisation du germoplasme disponible et d'effectuer une exploration plus approfondie des ressources génétiques locales, tandis que le séquençage ADN devenu plus rapide et meilleur marché se traduira par une meilleure compréhension de la base génétique sousjacente des caractères. Le recours à des outils génomiques pour augmenter la résilience animale, réduire les émissions de méthane du cheptel bovin et ovin, améliorer la résistance aux maladies, diminuer l'impact environnemental, réduire la concurrence pour les terres et les ressources hydrographiques et, enfin, accroître la production pourrait être la voie à suivre la plus réaliste pour l'avenir de la production animale. Les auteurs examinent plusieurs stratégies génomiques à la lumière du changement climatique, en se concentrant sur la sélection des animaux résistants/tolérants, sur la génomique du paysage, sur la métagénomique et sur l'édition génomique.

Según apuntan las predicciones, el cambio climático va a modificar la naturaleza y la distribución de los sistemas agropecuarios del mundo y por doquier en el planeta harán falta estrategias destinadas a adaptar y optimizar los sistemas de producción de alimentos. Para que las herramientas de la genómica sean útiles, en caso de que efectivamente se cumplan estos augurios, es indispensable disponer de detalladas caracterizaciones fenotípicas, muestreos sistemáticos y tipificaciones génicas a gran escala de las poblaciones animales. Las herramientas de la genómica mejorarán mucho la caracterización del germoplasma existente y el estudio de los recursos genéticos locales, a la vez que la secuenciación de ADN, cada vez más rápida y barata, nos aporta ya un conocimiento más profundo de la base genética de los rasgos fenotípicos. Quizá el camino más practicable para el porvenir de la producción ganadera sea el que pasa por utilizar las herramientas de la genómica para conferir más resiliencia a los animales, reducir las emisiones de metano del ganado vacuno y ovino, mejorar la resistencia a enfermedades, atenuar el impacto ambiental, reducir la competencia por los suelos y el agua y, por último, incrementar la producción. Los autores examinan una serie de estrategias genómicas desde la óptica del cambio climático, centrándose en la selección de animales resistentes o tolerantes, la genómica de paisajes, la metagenómica y la edición génica.

Reducing risks of human exposure to antimicrobial resistance originating from livestock supply chains.

Antimicrobial resistance is one of the biggest health threats for both humans and animals. This justifies the need for a conceptual framework that provides an integrated assessment of the measures and strategies that can be applied within livestock supply chains to reduce the risks of human exposure to resistant pathogens. The aim of this study is therefore to provide a comprehensive supply- chain-based conceptualisation that describes the main measures and strategies to reduce the risks of human exposure to resistant pathogens. The conceptual framework presented in this study makes a distinction between on-farm and beyond-farm decision-making. The on-farm decision-making context focuses on the strategies that can reduce antimicrobial use. The beyond-farm decision-making context focuses on the prevalence of (pathogenic) microorganisms. The focus of this framework is on Western European food production systems. A panel of Dutch experts on antimicrobial issues assessed various aspects of the framework, including correctness, completeness and consistency. They concluded that the conceptual framework provides a sound theoretical basis for economic decision support for policy-makers to reduce the risks of human exposure to resistant pathogens originating from livestock supply chains.

La résistance aux agents antimicrobiens constitue l'une des plus graves menaces pesant actuellement sur la santé tant humaine qu'animale. Ce constat justifie de concevoir un cadre conceptuel permettant de procéder à l'évaluation intégrée des mesures et des stratégies applicables tout au long de la chaîne d'approvisionnement de la filière élevage afin de réduire les risques d'exposition humaine à des agents pathogènes résistants. L'étude présentée par les auteurs a donc pour but de fournir une conceptualisation exhaustive fondée sur la chaîne d'approvisionnement et décrivant les principales mesures et stratégies de réduction des risques d'exposition humaine aux agents pathogènes résistants. Ce cadre conceptuel différencie deux contextes distincts de la prise de décision, d'une part les exploitations elles-mêmes et d'autre part les contextes extérieurs aux élevages. Les décisions prises dans les exploitations sont centrées sur les stratégies visant à réduire la quantité d'agents antimicrobiens utilisés. Les décisions relevant des contextes extérieurs aux élevages sont axées sur la prévalence des micro-organismes (pathogènes). Le cadre couvre les systèmes de production agroalimentaires d'Europe occidentale. Un groupe néerlandais d'experts de la lutte contre l'antibiorésistance a évalué ce cadre sous divers aspects, dont les paramètres de justesse, de complétude et de cohérence. Il en ressort que ce cadre conceptuel apporte aux responsables de l'élaboration des politiques une base théorique solide en soutien des décisions économiques visant à réduire les risques d'exposition humaine aux agents pathogènes résistants ayant pour source les chaînes d'approvisionnement du secteur de l'élevage.

La resistencia a los antimicrobianos es una de las mayores amenazas que pesan sobre la salud de humanos y animales, hecho que por sí solo justifica la necesidad de un marco teórico en el que inscribir una evaluación integrada de las medidas y estrategias que se pueden aplicar dentro de las cadenas de abastecimiento de ganado para reducir el riesgo de exposición humana a agentes patógenos resistentes. En este sentido, los autores describen un estudio encaminado a encuadrar la cadena de abastecimiento en coordenadas teóricas desde las cuales describir las principales medidas y estrategias para reducir el mencionado riesgo de exposición humana. El marco teórico presentado en este estudio distingue entre los ámbitos de decisión situados «en la explotación¼ y los que residen «más allá de la explotación¼. El ámbito decisorio de la explotación incide esencialmente en los dispositivos que puedan llevar a reducir el uso de antimicrobianos, mientras que las decisiones que trascienden el ámbito de la explotación se centran en la prevalencia de los microorganismos (agentes patógenos). El marco aquí presentado tiene por principal referencia los sistemas de producción alimentaria de Europa occidental. Tras evaluar varios de sus aspectos, en particular su corrección, su exhaustividad y su coherencia, un grupo sobre antimicrobianos formado por expertos neerlandeses llegó a la conclusión de que este marco conceptual proporciona sólidas bases teóricas en las que fundamentar, desde el punto de vista económico, las decisiones de las instancias de planificación para reducir el riesgo de exposición humana a agentes patógenos resistentes procedentes de las cadenas de abastecimiento de ganado.