Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 104
Filtrar
1.
Med Microbiol Immunol ; 213(1): 4, 2024 Mar 27.
Artigo em Inglês | MEDLINE | ID: mdl-38532203

RESUMO

Besides being scarce, the drugs available for treating cutaneous leishmaniasis have many adverse effects. Ozone is an option to enhance the standard treatment due to the wound-healing activity reported in the literature. In this study, we evaluated the efficiency of ozonated sunflower oil as an adjuvant in treating cutaneous lesions caused by Leishmania amazonensis. BALB/c mice were infected with L. amazonensis, and after the lesions appeared, they were treated in four different schedules using the drug treatment with meglumine antimoniate (Glucantime®), with or without ozonated oil. After thirty days of treatment, the lesions' thickness and their parasitic burden, blood leukocytes, production of NO and cytokines from peritoneal macrophages and lymph node cells were analyzed. The group treated with ozonated oil plus meglumine antimoniate showed the best performance, improving the lesion significantly. The parasitic burden showed that ozonated oil enhanced the leishmanicidal activity of the treatment, eliminating the parasites in the lesion. Besides, a decrease in the TNF levels from peritoneal macrophages and blood leukocytes demonstrated an immunomodulatory action of ozone in the ozonated oil-treated animals compared to the untreated group. Thus, ozonated sunflower oil therapy has been shown as an adjuvant in treating Leishmania lesions since this treatment enhanced the leishmanicidal and wound healing effects of meglumine antimoniate.


Assuntos
Antiprotozoários , Leishmaniose Cutânea , Ozônio , Animais , Camundongos , Antimoniato de Meglumina/farmacologia , Antimoniato de Meglumina/uso terapêutico , Óleo de Girassol/uso terapêutico , Antiprotozoários/farmacologia , Meglumina/farmacologia , Meglumina/uso terapêutico , Leishmaniose Cutânea/tratamento farmacológico , Leishmaniose Cutânea/parasitologia , Cicatrização , Ozônio/uso terapêutico , Camundongos Endogâmicos BALB C
2.
Int Wound J ; 21(3): e14812, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38444059

RESUMO

Kawasaki disease (KD) is one of the most challenging diseases that is defined as an acute vasculitis that affects the coronary arteries primarily in children. It causes complications if left untreated at early stages, ultimately leading to death. Corticosteroids have been recognized to treat and cause great impact on the patients with KD. Glucocorticoid is one of the main corticosteroids that are being used to treat KD and cutaneous wounds. However, ineffectiveness of a few glucocorticoids can limit the efficacy of this treatment. This study particularly aimed to elucidate the impact of glucocorticoids on cutaneous wounds in KD. To perform the meta-analysis, a comprehensive literature survey was conducted to unveil the studies and research conducted on Kawasaki patients that revealed different glucocorticoids in the form of specific interventions influencing KD. The literature was searched using numerous keywords, screened and data was extracted to perform the meta-analysis and then it was conducted using the metabin function of R package meta. A total of 2000 patients from both intervention and control groups were employed to carry out the meta-analysis to analyse and evaluate the impact of glucocorticoids on curing KD and cutaneous wounds in patients. The results disclosed that glucocorticoids along with other steroids, mainly IVIG (intravenous immunoglobulin), was an effective intervention to patients suffering from Kawasaki. The results depicted significant outcomes with the values (risk ratio [RR]: 1.08, 95% confidence interval [CI]: 0.58-2.00, p < 0.01) and enlightened the fact that adopting different glucocorticoids may significantly improve the efficacy of skin lesions along with KD. Hence, interventions of glucocorticoids must be utilized in the clinical practice to reduce the incidence of skin wounds and adverse effects caused due to KD.


Assuntos
Síndrome de Linfonodos Mucocutâneos , Lesões dos Tecidos Moles , Criança , Humanos , Síndrome de Linfonodos Mucocutâneos/tratamento farmacológico , Glucocorticoides/uso terapêutico , Ensaios Clínicos Controlados Aleatórios como Assunto , Razão de Chances
3.
Int Wound J ; 21(4): e14807, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38591163

RESUMO

Skin Cutaneous Melanoma (SKCM) is a form of cancer that originates in the pigment-producing cells, known as melanocytes, of the skin. Delay wound healing is often correlated with the occurrence of and progression of SKCM. In this comprehensive study, we investigated the intricate roles of two important wound healing genes in SKCM, including Matrix Metalloproteinase-2 (MMP2) and Matrix Metalloproteinase-9 (MMP9). Through a multi-faceted approach, we collected clinical samples, conducted molecular experiments, including RT-qPCR, bisulphite sequencing, cell culture, cell Counting Kit-8, colony formation, and wound healing assays. Beside this, we also used various other databases/tools/approaches for additional analysis including, UALCAN, GEPIA, HPA, MEXPRESS, cBioPortal, KM plotter, DrugBank, and molecular docking. Our results revealed a significant up-regulation of MMP2 and MMP9 in SKCM tissues compared to normal counterparts. Moreover, promoter methylation analysis suggested an epigenetic regulatory mechanism. Validations using TCGA datasets and immunohistochemistry emphasized the clinical relevance of MMP2 and MMP9 dysregulation. Functional assays demonstrated their synergistic impact on proliferation and migration in SKCM cells. Furthermore, we identified potential therapeutic candidates, Estradiol and Calcitriol, through drug prediction and molecular docking analyses. These compounds exhibited binding affinities, suggesting their potential as MMP2/MMP9 inhibitors. Overall, our study elucidates the diagnostic, prognostic, and therapeutic implications of MMP2 and MMP9 in SKCM, shedding light on their complex interplay in SKCM occurrence and progression.


Assuntos
Melanoma , Neoplasias Cutâneas , Humanos , Melanoma/genética , Melanoma/terapia , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/terapia , Metaloproteinase 2 da Matriz/genética , Metaloproteinase 9 da Matriz , Simulação de Acoplamento Molecular , Cicatrização/genética , Mutação , Metilação
4.
Can J Urol ; 30(3): 11562-11567, 2023 06.
Artigo em Inglês | MEDLINE | ID: mdl-37344469

RESUMO

Monkeypox virus (MPV) is a rare zoonotic infection caused by an orthopoxvirus. The sudden outbreak of more than 3000 MPV infection from 50 countries has led the WHO to declare the infection as an "evolving threat of moderate public health concern". Here, we describe a case series of two cases of the MPV with a similar onset of cutaneous lesions in the genital area but with different progression in 35 and 41-year-old males respectively. Both of our patients were reported heterosexual with a 10-day prior history of unprotected sexual activity with a sex worker. Case 1 was uncomplicated having rashes over the chest, back, arms, and legs along with the occurrence of fluid-filled painless vesicles which was managed with topical antibiotic cream and wound care using povidone-iodine dressing along with oral amoxicillin/clavulanic acid. On the contrary, case 2 had a progressive necrotic lesion, which spread from the root of the penis involving the foreskin despite supportive measures eventually requiring circumferential surgical debridement of the foreskin. Hence, given the current outbreak, we must consider the possibility of genital MPV in patients with suggestive lesions, anywhere on the body (including the genitals), added to an epidemiological link or history of intimate contact with individuals that may be at high risk for transmission.


Assuntos
Combinação Amoxicilina e Clavulanato de Potássio , Antibacterianos , Mpox , Adulto , Humanos , Masculino , Combinação Amoxicilina e Clavulanato de Potássio/uso terapêutico , Antibacterianos/uso terapêutico , Genitália Masculina/virologia , Mpox/diagnóstico , Mpox/tratamento farmacológico , Monkeypox virus , Resultado do Tratamento
5.
Mycopathologia ; 188(1-2): 63-70, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-36273348

RESUMO

Chromoblastomycosis (CBM) is a chronic, progressive fungal disease of the skin and subcutaneous tissue caused by a group of dematiaceous fungi. Verrucous lesions present parasite-rich granulomas and predominance of a Th2 patterns of cytokines. The inflammasome constitutes a macromolecular protein complex that play a role in the activation of caspase 1 that cleaves pro-IL1ß and pro-IL18, essential mediators of inflammation, and also activates pyroptosis. We intended to explore the presence and a possible role of inflammasome elements in cutaneous human lesions in CBM, considering the expression of IL1ß, IL18, caspase 1, NLRP1, and also RIPK3, a key downstream component of necroptosis signaling. 35 skin biopsies of cutaneous lesions of verrucous form of CBM and 10 biopsies from normal skin were selected. The diagnosis was based on histological and clinical analysis. An immunohistochemical protocol was performed. The histopathological analysis evidenced epidermis with hyperkeratosis, irregular acanthosis, and micro abscesses. The dermis presented suppurative granulomas and inflammatory infiltrate composed by giant cells, macrophages, epithelioid cells, lymphocytes, and some eosinophils. Positive cells were distributed in the inflammatory infiltrate, with an increased number of cells expressing caspase 1, IL1ß and IL18. Cells expressing RIPK3 and NLRP1 were less frequent. The intense presence of caspase 1, IL1ß and IL18, allied to NLRP1 expression, suggest that inflammasome and pyroptosis could play a role in the immune response against fungal agents of CBM. Our results, allied to data from literature, could suggest that inflammasome-mediated response and pyroptosis could be a target to be explored to decrease CBM lesions.


Assuntos
Cromoblastomicose , Inflamassomos , Humanos , Inflamassomos/metabolismo , Cromoblastomicose/patologia , Caspase 1/metabolismo , Interleucina-18/metabolismo , Apoptose
6.
Dermatol Ther ; 35(8): e15647, 2022 08.
Artigo em Inglês | MEDLINE | ID: mdl-35714173

RESUMO

There are several types of medical settings which use lasers. Dermatologists use lasers as it is non-invasive with preferential cosmetic outcomes and finer wound healing. The types of lasers are relying on their wavelengths and delivery systems. Over time, by using several distinct devices and strategies, new lasers have been generated; as a consequence, they are manipulated in a wide range of dermatological settings. In this review, laser applications in various vascular, infectious, and hyperpigmented cutaneous lesions were framed. We aimed to represent the fitness of phototherapy for each condition as well as the overall challenges that face laser. In addition, low-level laser therapy, and laser resurfacing were noted as the marketable line of lasers in the current time for cosmetic purposes.


Assuntos
Terapia a Laser , Terapia com Luz de Baixa Intensidade , Humanos , Lasers , Fototerapia , Cicatrização
7.
Acta Derm Venereol ; 101(7): adv00505, 2021 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-34159396

RESUMO

Genodermatoses are inherited syndromes with cutaneous manifestations. Some genodermatoses are associated with malignancy of internal organs and tissues. Early detection of the typical signs of these syndromes is important, because those lesions are a sign of underlying predisposition to extracutaneous neoplasms. The dermatologist has an important role in the early detection of these signs and syndromes, as early detection may affect the clinical course of the disease. We report here the characteristic cutaneous findings that dermatologists should be aware of in order to identify a genodermatosis with a possible associated malignancy. An updated overview of the pathogenesis and clinical findings of these syndromes is provided. Furthermore, surveillance protocols and treatment recommendations are explored.


Assuntos
Síndromes Neoplásicas Hereditárias , Humanos , Síndromes Neoplásicas Hereditárias/diagnóstico , Síndromes Neoplásicas Hereditárias/genética , Pele
8.
Australas J Dermatol ; 62(1): e98-e101, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32920868

RESUMO

An increasing number of publications have brought attention to COVID-19-associated cutaneous lesions. Histopathological descriptions and clinical correlation of the histopathological findings of COVID-19 skin lesions are lacking. In this manuscript, we reviewed and described the histopathological characteristics of COVID-19 infection cutaneous patterns reported in the literature.


Assuntos
Teste para COVID-19 , COVID-19/complicações , SARS-CoV-2/isolamento & purificação , Dermatopatias Virais/patologia , Biópsia , COVID-19/diagnóstico , COVID-19/patologia , Humanos , Dermatopatias Virais/diagnóstico
9.
J Pak Med Assoc ; 71(8): 2090-2092, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34418038

RESUMO

Germ cell tumours (GCT) are the most common malignancy in men between the ages of 15 and 35 years. Pure choriocarcinoma is a very rare entity of non- seminomatous germ cell tumour and comprises only 1% -3% of all the testicular tumours. Choriocarcinoma syndrome is a clinical condition in which haemorrhage occurs from the metastatic sites with elevated level of the Beta-Human Chorionic gonadotropin (Beta -HCG). A 15-year-old adolescent boy presented in with left sided testicular swelling along with dark coloured cutaneous lesions of the scalp, chest and chin for the last one month. He underwent left sided orchiectomy, and the histopathology report showed Pure Choriocarcinoma. Unfortunately, he died after the beginning of chemotherapy due to alveolar haemorrhage.


Assuntos
Coriocarcinoma , Neoplasias Embrionárias de Células Germinativas , Neoplasias Testiculares , Adolescente , Adulto , Gonadotropina Coriônica Humana Subunidade beta , Feminino , Humanos , Masculino , Neoplasias Embrionárias de Células Germinativas/diagnóstico , Gravidez , Neoplasias Testiculares/diagnóstico , Neoplasias Testiculares/cirurgia , Adulto Jovem
10.
Eur J Clin Microbiol Infect Dis ; 39(6): 1027-1042, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31873864

RESUMO

Blastocystis is one of the most common intestinal protozoan parasites worldwide, which is linked to cutaneous lesions and urticaria. In a setting of systematic review, the data on the association of Blastocystis infection with cutaneous lesions were searched in order to summarize the main clinical symptoms, diagnostic methods, treatment, and outcome of the patients. The search identified 28 eligible articles, including 12 cross-sectional studies and 16 case reports/case series (including 23 cases). A diverse spectrum of skin symptoms, mainly urticaria, rash, and itching, was reported from the studies. Of the 23 infected cases with the skin symptoms, gastrointestinal symptoms were reported from the 16 cases, whereas 7 cases with urticaria had asymptomatic infection. The most frequent subtypes were ST1, ST2, and ST3, respectively. Metronidazole, paromomycin, and tinidazole were the most prescribed drugs in patients with single Blastocystis infection. Notably, urticaria and other cutaneous symptoms of all treated patients were resolved after treatment. In conclusion, this study indicates that Blastocystis infection can be a neglected cause of urticaria and skin disorders. Since the treatment of Blastocystis infection is simple, screening and treatment of this infection should be considered in patients with urticaria and other skin disorders.


Assuntos
Infecções por Blastocystis/complicações , Dermatopatias/parasitologia , Urticária/parasitologia , Antiprotozoários/uso terapêutico , Infecções Assintomáticas/terapia , Blastocystis/classificação , Blastocystis/genética , Blastocystis/isolamento & purificação , Infecções por Blastocystis/diagnóstico , Infecções por Blastocystis/tratamento farmacológico , Variação Genética , Humanos , Enteropatias Parasitárias/complicações , Enteropatias Parasitárias/diagnóstico , Enteropatias Parasitárias/tratamento farmacológico , Dermatopatias/diagnóstico , Dermatopatias/tratamento farmacológico , Resultado do Tratamento , Urticária/diagnóstico , Urticária/tratamento farmacológico
11.
J Am Acad Dermatol ; 83(3): 773-779, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31706934

RESUMO

BACKGROUND: There is limited information on the profile of melanomas diagnosed in a specialist transplant dermatology clinic. OBJECTIVE: To describe the incidence and characteristics of incident primary melanomas in a cohort of organ transplant recipients (OTRs) attending a specialized transplant dermatology clinic and determine the number of pigmented lesions needed to excise for every melanoma diagnosed. METHODS: A retrospective study of 327 OTRs monitored by an Australian clinic during a 10-year period. RESULTS: There were 11 incident melanomas diagnosed during a total follow-up of 1280 patient-years. The mean interval between the first transplant and diagnosis was 5.5 years. Only 2 melanomas were >1 mm in Breslow thickness. Seven melanomas (64%) arose de novo. A contiguous nevus was present in 4 cases. Metastatic disease did not develop in the melanoma patients during the follow-up period, and all remain alive. The needed to excise for every melanoma diagnosed ratio was 16:1. LIMITATIONS: The crude incidence rates were age standardized, unlike the comparison rates of melanoma in the general population, and the cohort was small. CONCLUSION: Most melanomas diagnosed in OTR patients attending a specialized transplant dermatology service were detected early. Our data suggest early detection may reduce the proportion of OTRs presenting with thick melanomas, thus improving prognosis and patient outcomes. A needed to excise for every melanoma diagnosed ratio of 16:1 is not unreasonable for this cohort of high-risk patients. To our knowledge, this is the first time this ratio has been calculated for a cohort of OTRs.


Assuntos
Procedimentos Cirúrgicos Dermatológicos/estatística & dados numéricos , Melanoma/epidemiologia , Transplante de Órgãos/efeitos adversos , Neoplasias Cutâneas/epidemiologia , Transplantados/estatística & dados numéricos , Adulto , Idoso , Biópsia/estatística & dados numéricos , Feminino , Seguimentos , Humanos , Incidência , Masculino , Melanoma/etiologia , Melanoma/patologia , Melanoma/cirurgia , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Estudos Retrospectivos , Pele/patologia , Neoplasias Cutâneas/etiologia , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgia , Resultado do Tratamento , Vitória/epidemiologia
12.
J Cutan Pathol ; 47(2): 154-160, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31437317

RESUMO

Nivolumab and pembrolizumab are humanized IgG4 monoclonal antibodies against programmed cell death 1 (PD-1). Although these agents are effective in treating advanced melanoma, non-small-cell lung carcinoma, and other types of cancers, various adverse events have been reported. Cutaneous adverse events are particularly prevalent and, while granulomatous/sarcoid-like reactions are uncommon, they are increasingly recognized as immune-related adverse events associated with immune checkpoint inhibitors. Herein, we report two cases of granulomatous/sarcoid-like reaction with foreign material, mimicking metastatic malignancy after PD-1 inhibitor treatment. Clinicians should be aware of the existence of cutaneous lesions and perform biopsy if needed to prevent misdiagnosis and unnecessary adjustments to immunotherapy.


Assuntos
Toxidermias , Melanoma , Proteínas de Neoplasias/antagonistas & inibidores , Nivolumabe/efeitos adversos , Receptor de Morte Celular Programada 1/antagonistas & inibidores , Neoplasias Retais , Idoso , Toxidermias/diagnóstico , Toxidermias/metabolismo , Toxidermias/patologia , Humanos , Masculino , Melanoma/diagnóstico , Melanoma/tratamento farmacológico , Melanoma/metabolismo , Melanoma/patologia , Metástase Neoplásica , Proteínas de Neoplasias/metabolismo , Nivolumabe/administração & dosagem , Receptor de Morte Celular Programada 1/metabolismo , Neoplasias Retais/diagnóstico , Neoplasias Retais/tratamento farmacológico , Neoplasias Retais/metabolismo , Neoplasias Retais/patologia
13.
Dermatology ; 236(2): 143-144, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31473732

RESUMO

A fine and fair depiction of basal cell carcinoma is documented with great fidelity in "Caricature" by Bartolomeo Passerotti (1529-1592). The cancer is pearly white and contains an elevated centre with a sharp and somewhat depressed outline due to ulceration of the lesion. The painting is of essential didactic worth for practicing medical doctors. In addition, the masterpiece contains images of the brown elevated lesions that could turn out to be verrucous melanocytic nevi or pigmented seborrheic keratoses, but it cannot be excluded that these nodules are also basal cell carcinomas covered by a brownish crust. It is standard that microscopic verification is required for all these tumours. However, a pearly white irregular tumour is the most characteristic macroscopic presentation of basal cell carcinoma.


Assuntos
Carcinoma Basocelular/história , Caricaturas como Assunto/história , Medicina nas Artes/história , Neoplasias Cutâneas/história , Carcinoma Basocelular/diagnóstico , História do Século XVI , Humanos , Neoplasias Cutâneas/diagnóstico
14.
Mol Genet Metab ; 128(3): 288-297, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-30685241

RESUMO

Congenital erythropoietic porphyria (CEP) is a rare autosomal recessive disorder characterized by photosensitivity and by hematologic abnormalities in affected individuals. CEP is caused by mutations in the uroporphyrinogen synthase (UROS) gene. In three reported cases, CEP has been associated with a specific X-linked GATA1 mutation. Disease-causing mutations in either gene result in absent or markedly reduced UROS enzymatic activity. This in turn leads to the accumulation of the non-physiologic and photoreactive porphyrinogens, uroporphyrinogen I and coproporphyrinogen I, which damage erythrocytes and elicit a phototoxic reaction upon light exposure. The clinical spectrum of CEP depends on the level of residual UROS activity, which is determined by the underlying pathogenic loss-of-function UROS mutations. Disease severity ranges from non-immune hydrops fetalis in utero to late-onset disease with only mild cutaneous involvement. The clinical characteristics of CEP include exquisite photosensitivity to visible light resulting in bullous vesicular lesions which, when infected lead to progressive photomutilation of sun-exposed areas such as the face and hands. In addition, patients have erythrodontia (brownish discoloration of teeth) and can develop corneal scarring. Chronic transfusion-dependent hemolytic anemia is common and leads to bone marrow hyperplasia, which further increases porphyrin production. Management of CEP consists of strict avoidance of exposure to visible light with sun-protective clothing, sunglasses, and car and home window filters. Adequate care of ruptured vesicles and use of topical antibiotics is indicated to prevent superinfections and osteolysis. In patients with symptomatic hemolytic anemia, frequent erythrocyte cell transfusions may be necessary to suppress hematopoiesis and decrease marrow production of the phototoxic porphyrins. In severe transfection-dependent cases, bone marrow or hematopoietic stem cell transplantation has been performed, which is curative. Therapeutic approaches including gene therapy, proteasome inhibition, and pharmacologic chaperones are under investigation.


Assuntos
Vias Biossintéticas , Doenças Genéticas Inatas , Porfiria Eritropoética/genética , Porfiria Eritropoética/fisiopatologia , Animais , Fator de Transcrição GATA1/genética , Terapia Genética , Heme/metabolismo , Humanos , Camundongos , Mutação , Porfiria Eritropoética/complicações , Porfiria Eritropoética/terapia
15.
World J Surg Oncol ; 17(1): 90, 2019 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-31138233

RESUMO

INTRODUCTION: Dermatofibrosarcoma protuberans (DFSP) is a rare, low-grade malignant mesenchymal tumor of the soft tissue, characterized by slow infiltrative growth and common local recurrence, with rare distant metastases. PATIENTS AND METHODS: We present a retrospective study of nineteen patients who were diagnosed with DFSP and operated at our institution in > 10-year period. We examined the clinicopathological parameters with special emphasis on the margin status regarding the clinical outcome and the follow-up. RESULTS: A total of eight cases underwent re-excision at our institution following primary excision or incisional biopsy performed at a different institution. Seven cases received excision after incisional biopsy at our institution. Four patients developed recurrent disease following primary excision with histological R0 margins at other institutions and received re-excision at our institution. All excisions at our institution resulted in R0 margins with no recurrence recorded at last follow-up (6 to 175; mean 84 months). The mean margin for those who received resection at our institution was 1.67 cm. Negative margins upon primary excision were achieved using a mean margin width of 2.04 cm. Most common tumor localization was the trunk (10 cases). CONCLUSION: Awareness of this rare entity is important for a prompt diagnosis and a proper management of the disease. The greatest clinical challenge in the management of DFSP is achieving local control. Complete excision of the tumor with surgical margin widths of at least 2 cm is recommended.


Assuntos
Dermatofibrossarcoma/cirurgia , Procedimentos Cirúrgicos Dermatológicos/mortalidade , Neoplasias Cutâneas/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Dermatofibrossarcoma/patologia , Gerenciamento Clínico , Feminino , Seguimentos , Humanos , Masculino , Margens de Excisão , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Neoplasias Cutâneas/patologia , Taxa de Sobrevida
16.
Malar J ; 17(1): 349, 2018 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-30290813

RESUMO

BACKGROUND: Malaria is known to cause acute and deadly complications. However, malaria can cause unforeseen pathologies due to its chronicity. It increases the risk of endemic Burkitt Lymphoma development by inducing DNA damage in germinal centre (GC) B cells, and leading higher frequency of Epstein-Barr virus (EBV)-infected cells in GCs. EBV is well known for its tropism for B cells. However, less is known about EBV's interaction with T cells and its association with T cell lymphoma. CASE PRESENTATION: A 43-year-old Sudanese male admitted to hospital in Istanbul, Turkey, a non-endemic country, with hyperpigmented painful skin rashes on his whole body. A complete blood count and a peripheral blood smear during admission revealed large granular lymphocytes (LGLs) with abnormally higher CD8 T cell numbers. Additional skin biopsy and pathology results were compatible with CD8+ T cell lymphoproliferative disorder with skin involvement. Patient was treated and discharged. However, a pathologist noticed unusual structures in skin tissue samples. Careful evaluation of skin biopsy samples by polarized microscopy revealed birefringent crystalloid structures resembling malarial haemozoin mainly loaded in macrophages and giant histiocytes. After purification of DNA from the skin biopsy samples, nested PCR was performed for the detection of Plasmodium parasites and Plasmodium falciparum DNA was amplified. Because, the co-presence of EBV infection with malaria is a well-known aetiology of lymphoma, EBV-early RNA (EBER) transcripts were investigated in paraffin-embedded tissue samples and found to be positive in macrophage-like histiocytes. CONCLUSIONS: This is a unique case of malaria and EBV infection in a T-LGL lymphoma patient who presented in a non-endemic country. This case emphasizes the clinical importance of EBV monitoring in T-LGL patients with skin involvement. Notably, Plasmodium infection should be examined in patients from malaria endemic regions by pathological and molecular investigations.


Assuntos
Linfócitos T CD8-Positivos/imunologia , Infecções por Vírus Epstein-Barr/virologia , Linfoma/etiologia , Malária Falciparum/parasitologia , Adulto , Humanos , Masculino , Multimorbidade , Plasmodium falciparum/isolamento & purificação , Sudão/etnologia , Turquia
17.
J Cutan Pathol ; 45(1): 71-73, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29028126

RESUMO

Q fever caused by Coxiella burnetii usually presents asymptomatically or as an undifferentiated febrile disease and rarely as rash or other cutaneous manifestations of the disease. Here we present a 41-year-old male complaining of body ache, fever, nausea, malaise, bilateral knee pain and vomiting. Clinical examination revealed a notable erythematous blanching rash all over his body. Workup revealed positive serologic testing for C. burnetii and skin biopsy of the rash revealed leukocytoclastic vasculitis.


Assuntos
Febre Q/complicações , Vasculite Leucocitoclástica Cutânea/microbiologia , Adulto , Humanos , Masculino
18.
Ann Dermatol Venereol ; 144(11): 676-684, 2017 Nov.
Artigo em Francês | MEDLINE | ID: mdl-28965699

RESUMO

BACKGOUND: Over the last thirty years, the scientific community has become increasingly interested in the intestinal flora, whether commensal or pathogenic, and its impact on other organs. In dermatology, the correlation between intestinal microbial agents and cutaneous lesions is well established. Giardia duodenalis, an intestinal parasite, has been particularly widely studied. The aim of this work is to provide a review of studies demonstrating the involvement of G. duodenalis in various forms of dermatosis. PATIENTS AND METHODS: The data were obtained by an English-language literature search of Medline, PubMed and Google Scholar for the period 1975-2015. Among the thirty case reports since 1976, we selected the twenty most objective and clinically relevant. RESULTS AND DISCUSSION: This review demonstrates that intestinal giardiasis may be an etiological factor, either alone or in combination with other agents, of various dermatoses through inflammatory and allergic mechanisms or intestinal hyperpermeability. The mucocutaneous lesions are varied: urticaria, angioedema, atopic dermatitis, erythema nodosum, Wells syndrome, among others. The role and origin of the infection are often unknown, and it is thus difficult to determine the interval between parasite infestation and the onset of skin lesions. Consequently, a fecal examination to identify G. duodenalis should be considered in chronic urticaria or angioedema, and where atopic dermatitis occurs in adulthood without any specific etiology. Therapeutic test should be done in every suspicion.


Assuntos
Giardia lamblia/patogenicidade , Giardíase/complicações , Dermatopatias/etiologia , Angioedema/etiologia , Antiprotozoários/uso terapêutico , Celulite (Flegmão)/etiologia , Dermatite Atópica/etiologia , Eosinofilia/etiologia , Eritema Nodoso/etiologia , Feminino , Giardia lamblia/imunologia , Giardia lamblia/fisiologia , Giardíase/diagnóstico , Giardíase/tratamento farmacológico , Humanos , Hipersensibilidade/etiologia , Inflamação , Intestinos/parasitologia , Masculino , Dermatopatias/imunologia , Urticária/etiologia , Água/parasitologia
19.
Cancer Treat Res ; 167: 107-29, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26601860

RESUMO

The malignant cell in melanoma is the melanocyte. Because melanocytes are located in the basal layer of the epidermis, melanoma is most commonly seen on the skin. However, melanoma can also arise on mucosal surfaces such as the oral cavity, the upper gastrointestinal mucosa, the genital mucosa, as well as the uveal tract of the eye and leptomeninges. Melanomas tend to be pigmented but can also present as pink or red lesions. They can mimic benign or other malignant skin lesions. This chapter presents the spectrum of typical and less typical presentations of melanoma, as well as patterns of spread. It is divided into (1) cutaneous lesions; (2) patterns of regional spread, (3) non-cutaneous lesions; and (4) distant metastases.


Assuntos
Melanoma/patologia , Humanos , Melanoma/imunologia , Melanoma/secundário , Pele/patologia , Neoplasias Cutâneas/patologia , Neoplasias Uveais/patologia
20.
Eur J Pediatr ; 175(1): 147-9, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26195178

RESUMO

UNLABELLED: Colchicine is not usually considered a treatment option for cutaneous lesions of Henoch-Schönlein purpura (HSP) in children. We report a case of pediatric HSP with severe chronic and relapsing cutaneous manifestations that were resistant to corticosteroids. Colchicine had remarkable therapeutic efficacy, with positive dechallenge and rechallenge, without any adverse effects. CONCLUSION: Colchicine should be considered for chronic, severe cutaneous lesions of pediatric HSP. WHAT IS KNOWN: Colchicine is not usually considered a treatment option for cutaneous lesions of Henoch-Schönlein purpura (HSP) in children. What is New: We report a case of pediatric HSP with severe cutaneous manifestations that responded well to colchicine. Colchicine should be considered for chronic cutaneous lesions of HSP in children.


Assuntos
Colchicina/uso terapêutico , Vasculite por IgA/tratamento farmacológico , Pré-Escolar , Doença Crônica , Humanos , Vasculite por IgA/patologia , Masculino , Recidiva
SELEÇÃO DE REFERÊNCIAS
Detalhe da pesquisa