1.
Trends Biochem Sci
; 44(1): 2-6, 2019 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30293659
RESUMO
Nuclear receptors (NRs) form homo- and/or heterodimers as central scaffolds of multiprotein complexes, which activate or repress gene transcription to regulate development, homeostasis, and metabolism. Recent studies on NR quaternary structure reveal novel mechanisms of receptor dimerization, the existence of tetrameric chromatin-bound NRs, and previously unanticipated protein-protein/protein-DNA interactions.