Detalhe da pesquisa
1.
Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike.
PLoS Pathog
; 19(5): e1011308, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37126534
2.
The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2'-O-methylation.
PLoS Pathog
; 17(5): e1009562, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33956914
3.
Characterization of reverse-engineered anti-PF4 stereotypic antibodies derived from serum of patients with VITT.
Blood
; 143(4): 370-374, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37976451
4.
Development of a robust crystallization platform for immune receptor TREM2 using a crystallization chaperone strategy.
Protein Expr Purif
; 179: 105796, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33221505
5.
Discovery of novel N-1 substituted pyrazolopyrimidinones as potent, selective PDE2 inhibitors.
Bioorg Med Chem Lett
; 44: 128082, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33991626
6.
SAR towards indoline and 3-azaindoline classes of IDO1 inhibitors.
Bioorg Med Chem Lett
; 47: 128214, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34166782
7.
Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple species.
Bioorg Med Chem Lett
; 28(6): 1122-1126, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29534798
8.
The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design.
Bioorg Med Chem Lett
; 27(23): 5167-5171, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29113762
9.
Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.
Commun Biol
; 6(1): 1074, 2023 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37865687
10.
Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors.
J Virol
; 84(15): 7625-33, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20484498
11.
Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase.
Nat Commun
; 12(1): 3040, 2021 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34031403
12.
Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors.
ACS Med Chem Lett
; 12(3): 389-396, 2021 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33738066
13.
Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase.
BMC Struct Biol
; 10: 16, 2010 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20540760
14.
Expression, purification and crystallization of human prolylcarboxypeptidase.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 66(Pt 6): 702-5, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20516604
15.
Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1).
ACS Med Chem Lett
; 11(4): 550-557, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292563
16.
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol
; 27(1): 32-40.e3, 2020 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31653597
17.
The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors.
Bioorg Med Chem Lett
; 18(11): 3386-91, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18455394
18.
Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV-1 Integrase Inhibitors with Antiretroviral Activity.
ACS Chem Biol
; 12(11): 2858-2865, 2017 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29024587
19.
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol
; 28(2): 243, 2021 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33607006
20.
Protein expression plasmids produced rapidly: streamlining cloning protocols and robotic handling.
Assay Drug Dev Technol
; 3(6): 661-74, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16438661