Detalhe da pesquisa
1.
Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.
Mol Cell
; 53(2): 247-61, 2014 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24389101
2.
The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance.
Nat Immunol
; 10(1): 92-100, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19011628
3.
An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.
Nat Chem Biol
; 13(4): 381-388, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28135235
4.
SETDB1 modulates PRC2 activity at developmental genes independently of H3K9 trimethylation in mouse ES cells.
Genome Res
; 25(9): 1325-35, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26160163
5.
Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.
Blood
; 123(9): 1341-52, 2014 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24415537
6.
Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy.
Proc Natl Acad Sci U S A
; 110(17): 6841-6, 2013 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-23569248
7.
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation.
Proc Natl Acad Sci U S A
; 109(52): 21360-5, 2012 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23236167
8.
A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferaseâ 3 (PRMT3).
Angew Chem Int Ed Engl
; 54(17): 5166-70, 2015 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25728001
9.
Absolute quantification of histone PTM marks by MRM-based LC-MS/MS.
Anal Chem
; 86(19): 9679-86, 2014 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25166916
10.
Loss of Wdr5 attenuates MLL-rearranged leukemogenesis by suppressing Myc targets.
Biochim Biophys Acta Mol Basis Dis
; 1869(2): 166600, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36402263
11.
Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction.
ACS Chem Biol
; 18(1): 34-40, 2023 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36594833
12.
Histone deacetylase inhibitors activate NF-κB in human leukemia cells through an ATM/NEMO-related pathway.
J Biol Chem
; 291(34): 17535, 2016 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27543593
13.
Structure of human SMYD2 protein reveals the basis of p53 tumor suppressor methylation.
J Biol Chem
; 286(44): 38725-38737, 2011 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21880715
14.
IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms.
Blood
; 115(12): 2430-40, 2010 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20086250
15.
Pan-histone deacetylase inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic antimyeloid activity in combination with CXCR4 antagonists.
Blood
; 116(24): 5306-15, 2010 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-20810927
16.
Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589).
Drug Metab Dispos
; 40(5): 1041-50, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22344701
17.
Detecting S-adenosyl-L-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay.
Anal Biochem
; 423(1): 171-7, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22342622
18.
Analysis of pan-African Centres of excellence in health innovation highlights opportunities and challenges for local innovation and financing in the continent.
BMC Int Health Hum Rights
; 12: 11, 2012 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22838941
19.
Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J Med Chem
; 65(7): 5317-5333, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35352560
20.
Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway.
J Biol Chem
; 285(13): 10064-10077, 2010 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20065354