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1.
Facial Plast Surg ; 39(2): 125-129, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35577032

RESUMO

Fixation of the cartilaginous vault is an important maneuver in preservation rhinoplasty to reduce hump recurrences. This paper presents a cartilaginous vault fixation technique with a barbed suture. Forty-six patients who underwent closed-approach high-septal-resection dorsal preservation rhinoplasty between August 2019 and March 2020 were included in this retrospective study. According to the cartilaginous vault fixation sutures applied, the patients were divided into two main groups as follows: (1) barbed suture and (2) conventional suture. Standardized postoperative 1-month lateral view photographs were scanned for the presence of any degree of hump recurrence. The Rhinoplasty Outcome Evaluation (ROE) scale was applied at 12 months. Hump recurrence was detected in one patient in the barbed suture group (n = 21) and one patient in the conventional suture group (n = 25; p > 0.05). For the ROE scores and number of satisfied patients, no statistically significant difference was found between the barbed and conventional suture fixation techniques (p > 0.05). Fixation with barbed suture showed similar results to conventional suture fixation. Barbed sutures can be used for cartilaginous vault fixation, taking advantage of the ease of placement in closed rhinoplasty. This study reflects level of evidence IV.


Assuntos
Rinoplastia , Humanos , Rinoplastia/métodos , Estudos Retrospectivos , Resultado do Tratamento , Cartilagem , Técnicas de Sutura , Suturas
2.
Clin Exp Obstet Gynecol ; 43(3): 388-92, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27328497

RESUMO

UNLABELLED: PURPOSE OFINVESTIGATION: To assess the frequency of oral cytological abnormalities in women who have cervical intraepithelial lesions, and transmission of infection depending on their sexual behavior. The authors also aimed to investigate the oral cytological changes in male partners. MATERIAL AND METHODS: Thirty patients with abnormal cervical cytological results via punch biopsy formed the case group, and 68 patients constituted the control group with normal cervical smear results. The Bethesda system was used for classification of the cytological alterations. RESULTS: Oral dysplasia was significantly higher in the squamous intraepithelial lesion (SIL) group. Oral sex percentage was 43.3% in SIL group, whereas it was 19.1% in the control group. History of genital warts in women with SIL was also significantly higher in the case group. Three patients were diagnosed with abnormal oral cytology in the SIL group (10%), however abnormal oral cytology was not detected in the control group. No oral dysplastic changes was identified in the male partners of women with oral lesions. CONCLUSION: The authors detected oral dysplastic changes in the SIL group, especially in the (low grade squamous intraepithelial lesion (LGSIL) patients. Interestingly they could not find any oral dysplastic changes in the male partners of the study population.


Assuntos
Condiloma Acuminado/epidemiologia , Mucosa Bucal/patologia , Neoplasias Bucais/epidemiologia , Comportamento Sexual/estatística & dados numéricos , Parceiros Sexuais , Lesões Intraepiteliais Escamosas Cervicais/epidemiologia , Adolescente , Adulto , Consumo de Bebidas Alcoólicas/epidemiologia , Biópsia , Estudos de Casos e Controles , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias Bucais/patologia , Lesões Pré-Cancerosas/epidemiologia , Lesões Pré-Cancerosas/patologia , Prevalência , Fumar/epidemiologia , Lesões Intraepiteliais Escamosas Cervicais/patologia , Turquia/epidemiologia , Displasia do Colo do Útero/epidemiologia , Displasia do Colo do Útero/patologia , Adulto Jovem
3.
Psychopharmacology (Berl) ; 90(2): 244-6, 1986.
Artigo em Inglês | MEDLINE | ID: mdl-3024198

RESUMO

In the present study, the mechanism of the antagonistic action of 0.5 mg/kg diazepam on the analgesic effect of morphine was investigated. While Ro 15-1788, a benzodiazepine receptor antagonist, was found to partially reverse the inhibitory action of diazepam on morphine analgesia, a chloride channel blocking agent, picrotoxin, produced complete antagonism of the action of diazepam. Furthermore, picrotoxin potentiated the partial antagonistic effect of Ro 15-1788 at a normally ineffective dose to affect the 0.5 mg/kg diazepam-morphine dose-response curve. These overall effects of picrotoxin on the supramolecular GABA receptor complex are discussed.


Assuntos
Analgésicos , Morfina/farmacologia , Receptores de GABA-A/fisiologia , Animais , Diazepam/farmacologia , Relação Dose-Resposta a Droga , Flumazenil/farmacologia , Masculino , Camundongos , Picrotoxina/farmacologia , Receptores de GABA-A/efeitos dos fármacos
4.
Psychopharmacology (Berl) ; 63(2): 169-72, 1979 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-112635

RESUMO

The present experiments dealt the effects of delta 9-tetrahydrocannabinol (THC) on the locomotor activity stimulating action of morphine in mice. In the first series of experiments, the pretreatments of mice by THC in doses up to 20 mg/kg have been found to potentiate the morphine-induced hyperactivity in dose-dependent manner, but higher doses of THC did not produce such an action. In the second series of experiments the dose-response curve of morphine for the motor activity has been found to shift to the left by the pretreatment of mice with 10 mg/kg of THC. These results show a synergism between morphine and THC and suggest that both drugs may share some common site of action.


Assuntos
Dronabinol/farmacologia , Morfina/farmacologia , Atividade Motora/efeitos dos fármacos , Animais , Interações Medicamentosas , Masculino , Camundongos , Fatores de Tempo
5.
Psychopharmacology (Berl) ; 78(4): 358-60, 1982.
Artigo em Inglês | MEDLINE | ID: mdl-6296906

RESUMO

Acute treatment of rats either by high doses of morphine or delta 9-tetrahydrocannabinol (THC) decreased locomotor activity. Naloxone reversed morphine-induced depression completely and reversed THC-induced depression only partially. On day 3 of treatment, tolerance developed to the locomotor inhibitory action of THC or morphine and partial cross-tolerance was observed to the depressant action of THC. Naloxone slightly depressed locomotor activity in THC-tolerant rats, but increased motor activity in morphine-tolerant rats.


Assuntos
Dronabinol/farmacologia , Morfina/farmacologia , Atividade Motora/efeitos dos fármacos , Animais , Tolerância a Medicamentos , Humanos , Masculino , Dependência de Morfina/psicologia , Ratos
6.
Psychopharmacology (Berl) ; 69(2): 201-5, 1980.
Artigo em Inglês | MEDLINE | ID: mdl-6256790

RESUMO

The effect of delta 9-tetrahydrocannabinol (THC) on the locomotor activity-stimulating action of morphine has been investigated in mice. THC (10 mg/kg) has been found to potentiate morphine-induced hyperactivity. On the other hand, the stimulating action of morphine on motor activity strongly diminished in mice rendered tolerant by the implantation of a morphine pellet. The pretreatment of morphine-tolerant mice with the same dose of THC did not change the effect of morphine on the motor activity. These results suggest that tolerance also developed to the potentiating action of THC on morphine-induced hyperactivity during the development of tolerance to this action of morphine.


Assuntos
Dronabinol/farmacologia , Morfina/farmacologia , Atividade Motora/efeitos dos fármacos , Animais , Implantes de Medicamento , Sinergismo Farmacológico , Tolerância a Medicamentos , Camundongos , Morfina/administração & dosagem , Fatores de Tempo
7.
Eur J Pharmacol ; 70(2): 219-24, 1981 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-6266844

RESUMO

Chlornaltrexamine (beta-CNA) a selective, long-acting irreversible opiate antagonist inhibited the analgesia, hypothermia, hypothermia tolerance and physical dependence produced by delta 9-tetrahydrocannabinol (THC) in rats. The results suggest that there are some common features between cannabis and opiates and some actions of THC may be mediated by opioid related mechanisms in the central nervous system.


Assuntos
Dronabinol/antagonistas & inibidores , Naloxona/análogos & derivados , Naltrexona/análogos & derivados , Antagonistas de Entorpecentes/farmacologia , Analgesia , Animais , Dronabinol/farmacologia , Tolerância a Medicamentos , Humanos , Hipotermia/induzido quimicamente , Masculino , Morfina/farmacologia , Naltrexona/farmacologia , Compostos de Mostarda Nitrogenada/farmacologia , Ratos , Receptores Opioides/efeitos dos fármacos , Transtornos Relacionados ao Uso de Substâncias
8.
Eur Neuropsychopharmacol ; 7(2): 161-3, 1997 May.
Artigo em Inglês | MEDLINE | ID: mdl-9169304

RESUMO

A young female with organic delusional syndrome induced by hyperprolactinemia was admitted to the Psychiatry Clinic of Ankara Social Security Hospital. The most striking characteristic of her history was either worsening of the endocrinologic clinical outcome under conventional neuroleptic treatment or worsening of clinical psychiatric outcome under bromocriptine therapy. A new atypical neuroleptic, melperone, suggested to minimally affect plasma prolactin levels, was started. Her psychotic complaints significantly subsided and she was devoid of any symptomatological change regarding her endocrinological status. These results were discussed.


Assuntos
Antipsicóticos/uso terapêutico , Butirofenonas/uso terapêutico , Delusões/tratamento farmacológico , Hiperprolactinemia/fisiopatologia , Adulto , Feminino , Humanos
9.
Eur Neuropsychopharmacol ; 9(1-2): 45-50, 1999 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-10082227

RESUMO

The present study was undertaken to determine the effects of chronic flumazenil treatment alone and simultaneously with diazepam on acquisition performance in an active-avoidance task and on locomotor activity in rats. Flumazenil (5, 10 and 20 mg/kg) and diazepam (0,5, 1.0 and 2.0 mg/kg) were administered intraperitoneally to rats before each daily training session for 5 days. The baseline of avoidance performance was set to approximately 50% and responses were expressed as acquisition rate. Locomotor activity of the rats was simultaneously recorded but only following the first training session. Diazepam decreased acquisition rate between the dose range used. Flumazenil had no effect on the acquisition rate of naive rats but reversed low dose diazepam-induced learning and memory impairment. Diazepam induced locomotor depression within the same dose range that decreased acquisition rate. Flumazenil had no effect on locomotor activity, but reversed the locomotor depressant effect of diazepam. The striking contradiction with previous data that flumazenil has no effect on learning-memory processing is discussed.


Assuntos
Ansiolíticos/farmacologia , Aprendizagem da Esquiva/efeitos dos fármacos , Diazepam/farmacologia , Flumazenil/farmacologia , Moduladores GABAérgicos/farmacologia , Atividade Motora/efeitos dos fármacos , Animais , Ansiolíticos/administração & dosagem , Depressão Química , Diazepam/administração & dosagem , Relação Dose-Resposta a Droga , Flumazenil/administração & dosagem , Moduladores GABAérgicos/administração & dosagem , Injeções Intraperitoneais , Masculino , Ratos , Ratos Wistar , Fatores de Tempo
10.
Epilepsy Res ; 25(3): 185-90, 1996 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-8956915

RESUMO

The present study was undertaken to evaluate the antiseizure activity spectrum of insulin against various behavioral seizure models in rats. Insulin was injected intraperitoneally (i.p.) at a test dose of 1 U/kg. Dextrose (3 g/kg) was administered simultaneously with insulin to counteract its hypoglycemic effect and induce a normoglycemic state. Insulin was found to significantly decrease the incidence, intensity and mortality rate and prolong the latency of generalized tonic-clonic convulsions induced by pentylenetetrazole (60 mg/kg i.p.) and significantly decrease the intensity and mortality rate and prolong the latency of generalized tonic-clonic convulsions induced by penicillin (2000 U/intracerebrocortical). Insulin was not only found to prolong the latency of all the seizure components but was found to reduce the incidence of focal myoclonic twitches and generalized tonic-clonic convulsions induced by kainic acid (12 mg/kg i.p.) as well. Insulin was shown to be ineffective to suppress ouabain (5 micrograms/intracerebroventricular) induced seizures. These findings indicate that insulin possesses a broad spectrum of antiseizure activity in rats. Interaction with brain Na(+)-K(+)-ATPase has been discussed as a possible mechanism of action.


Assuntos
Anticonvulsivantes/uso terapêutico , Convulsivantes/antagonistas & inibidores , Hipoglicemiantes/uso terapêutico , Insulina/uso terapêutico , Convulsões/tratamento farmacológico , Animais , Anticonvulsivantes/sangue , Glicemia/metabolismo , Avaliação Pré-Clínica de Medicamentos , Glucose/farmacologia , Hipoglicemiantes/sangue , Insulina/sangue , Ácido Caínico/antagonistas & inibidores , Masculino , Ouabaína/antagonistas & inibidores , Penicilinas/antagonistas & inibidores , Pentilenotetrazol/antagonistas & inibidores , Ratos , Ratos Wistar , Tempo de Reação/efeitos dos fármacos , Convulsões/induzido quimicamente
11.
Pharmacol Biochem Behav ; 46(2): 383-9, 1993 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-7505455

RESUMO

Centrally mediated effects of iloprost, a stable analogue of PGI2, on rectal temperature have been investigated in conscious rats. ICV administration of iloprost (100-1,000 ng, ICV) produced a dose-dependent, monophasic hyperthermic response that was not inhibited by indomethacin. When injected into the preoptic anterior hypothalamic (POAH) region, iloprost (2-50 ng/POAH) induced a biphasic increase in rectal temperature. While the first phase was inhibited by AH 6809, an E1-type prostaglandin (EP1) receptor antagonist, the second phase was abolished by indomethacin pretreatment. Iloprost was found not to alter rectal temperature when injected into the ventromedial hypothalamic area. Administration of iloprost into the POAH in a dose that had no effect on rectal temperature significantly potentiated the hyperthermic effect of PGE2 (50 ng, ICV). These findings suggest that the pyrogenic effect of iloprost is partly mediated by EP1 receptors located on the POAH. Regarding the similarities of iloprost and PGI2, it is further proposed that endogenous PGI2 might act to modulate hyperthermic effect of PGE2 released during arachidonic acid- or endogenous pyrogen-induced fever.


Assuntos
Temperatura Corporal/efeitos dos fármacos , Dinoprostona/farmacologia , Iloprosta/farmacologia , Xantonas , Animais , Dinoprostona/administração & dosagem , Dinoprostona/antagonistas & inibidores , Relação Dose-Resposta a Droga , Sinergismo Farmacológico , Iloprosta/administração & dosagem , Iloprosta/antagonistas & inibidores , Indometacina/farmacologia , Injeções , Injeções Intraventriculares , Masculino , Área Pré-Óptica , Antagonistas de Prostaglandina/farmacologia , Ratos , Ratos Wistar , Receptores de Prostaglandina E/efeitos dos fármacos , Xantenos/farmacologia
12.
Pharmacol Biochem Behav ; 25(1): 215-7, 1986 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-3018793

RESUMO

Diazepam within its therapeutic dose range, was shown to have no effect on nociception, but was shown to antagonize the analgesic action of morphine. This antagonism was found to be statistically significant at 0.5 mg/kg diazepam. To elucidate the mechanism of this inhibitory action of diazepam against morphine analgesia, Ro 15-1788, the specific antagonist of benzodiazepine receptors was used. As a result, Ro 15-1788 was found to partially reverse the inhibitory action of diazepam against morphine analgesia. This overall interaction between the supramolecular GABA receptor complex and morphine is discussed.


Assuntos
Diazepam/farmacologia , Morfina/antagonistas & inibidores , Dor/tratamento farmacológico , Receptores de GABA-A/efeitos dos fármacos , Animais , Benzodiazepinonas/administração & dosagem , Diazepam/administração & dosagem , Interações Medicamentosas , Flumazenil , Masculino , Camundongos , Morfina/administração & dosagem
13.
Methods Find Exp Clin Pharmacol ; 14(7): 517-22, 1992 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-1283772

RESUMO

The effects of iloprost, a chemically stable analog of prostacyclin, on motor activity, pentylenetetrazol (PTZ)- and strychnine (ST)-induced seizures were studied in rats. Depression on motor activity was observed after a 500 ng/icv dose. Thus, both spontaneous locomotor activity and exploratory behavior were significantly reduced. While iloprost was ineffective against ST-induced seizures, it produced dose-dependent inhibition of PTZ-induced seizures. ED50 (95% confidence limits) value of iloprost for the suppression of clonic convulsions induced by PTZ was 224.96 (100.43-504.00) ng/icv. Anticonvulsive effect of iloprost was significantly potentiated by clonazepam pretreatment. In this case ED50 of iloprost was 39.40 (23.88-65.01) ng/icv. Unilateral iloprost injections into substantia nigra pars reticulata in a relatively lower dose range (0.5-2.0 ng/ic) also dose-dependently inhibited PTZ-induced seizures. In comparison to other prostanoids iloprost seems to have more potent and selective anticonvulsive activity against PTZ-induced seizures without marked motor depressant action in rats. It is further suggested that antiseizure effect of iloprost might be mediated by GABAergic inhibitory mechanisms.


Assuntos
Iloprosta/farmacologia , Atividade Motora/efeitos dos fármacos , Convulsões/tratamento farmacológico , Animais , Clonazepam/farmacologia , Iloprosta/administração & dosagem , Injeções Intraventriculares , Masculino , Ratos , Convulsões/induzido quimicamente
14.
Methods Find Exp Clin Pharmacol ; 11(4): 273-5, 1989 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-2474118

RESUMO

Intraperitoneally (i.p.) administered iloprost produced a writhing response indicating nociception. This effect induced by 4 micrograms/kg iloprost was dose dependently protected by morphine with an ED50 (95% confidence limits) value of 0.039 (0.0018-0.067) mg/kg. On the other hand, indomethacin had no effect on iloprost-induced writhing. Thus, this effect of iloprost seems to be relatively more sensitive than other irritants-induced responses on determining the analgesic potency of narcotic drugs.


Assuntos
Fármacos Cardiovasculares/farmacologia , Epoprostenol/farmacologia , Morfina/farmacologia , Dor/induzido quimicamente , Animais , Fármacos Cardiovasculares/antagonistas & inibidores , Relação Dose-Resposta a Droga , Epoprostenol/antagonistas & inibidores , Iloprosta , Injeções Intraperitoneais , Masculino , Camundongos , Fatores de Tempo
17.
Med Educ Online ; 13: 8, 2008 Jun 09.
Artigo em Inglês | MEDLINE | ID: mdl-20165538

RESUMO

The present study was undertaken to identify the perceptions of students about their educational environment in a newly restructured curriculum. The Turkish version of the DREEM questionnaire (total score: 200) was used to diagnose the strengths and weaknesses of the curriculum which is known to be a major determinant of educational environment. Five hundred fifty three students (years 1, 3, 5) voluntarily replied to the questionnaire. The mean DREEM score was found to be 117.63 (58.8%). The mean scores for the whole DREEM questionnaire and the five essential domains were found to be significantly different in different phases of medical education. The scores were found to be highest (123.65) for year 3 students and lowest (109.39) for year 5 students. The results are the first data of a curriculum reform obtained from the students about the educational environment and give important feedback to curriculum planners and change managers of the faculty for necessary improvement.

18.
Arch Int Pharmacodyn Ther ; 223(2): 282-6, 1976 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-999411

RESUMO

The influence of 6-hydroxydopamine on morphine-induced convulsions were investigated in rats. Morphine, in doses up to 100 mg/kg did not produce any convulsive pattern in vehicle-pretreated rats. The pretreatment of rats by 6-hydroxydopamine strongly potentiated the seizure producing activity of morphine and the dose-response curve of seizure severity shifted to the right. These results suggest that brain catecholamines are involved in the mechanism of morphine-induced convulsions.


Assuntos
Hidroxidopaminas/farmacologia , Morfina/farmacologia , Convulsões/induzido quimicamente , Animais , Sinergismo Farmacológico , Masculino , Ratos
19.
Gen Pharmacol ; 33(3): 237-41, 1999 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-10480656

RESUMO

Metamizol produced a dose- and time-dependent relaxation in rabbit thoracic aorta smooth muscle that was precontracted by phenylephrine. Such a relaxation was not observed with indomethacin, which is also a nonsteroidal anti-inflammatory drug. The relaxing effect of metamizol was independent of the presence of vascular endothelium. Tetraethylammonium (a calcium-activated potassium channel inhibitor), glybenclamide (an ATP-dependent potassium channel inhibitor), indomethacin (a cyclooxygenase inhibitor), and methylene blue (a soluble guanylate cyclase inhibitor) did not have any effect on metamizol-induced relaxation response. Metamizol did not produce any relaxation effect on aortic smooth muscle when KCl (30, 60, and 117 mM KCl) was used instead of phenylephrine to precontract the preparation. Ouabain (a Na-K ATPase pump inhibitor) showed a dose-dependent inhibition on metamizol's relaxation response. However, in potassium-free medium, which is an alternative way to block the Na-K ATPase pump, no inhibition in metamizol-induced relaxation response was observed. When metamizol was incubated for 2 h in organ-bath conditions before evaluating its relaxing effect, it produced a relatively faster relaxation, indicating that the relaxing effect of metamizol is produced by one of its (active) spontaneous degradation products (possibly 4-methylaminoantipyrine).


Assuntos
Anti-Inflamatórios não Esteroides/farmacologia , Aorta Torácica/efeitos dos fármacos , Dipirona/farmacologia , Relaxamento Muscular/efeitos dos fármacos , Músculo Liso Vascular/efeitos dos fármacos , Fenilefrina/farmacologia , Animais , Aorta Torácica/fisiologia , Relação Dose-Resposta a Droga , Inibidores Enzimáticos/farmacologia , Feminino , Glibureto/farmacologia , Técnicas In Vitro , Indometacina/farmacologia , Masculino , Azul de Metileno/farmacologia , Contração Muscular/efeitos dos fármacos , Músculo Liso Vascular/fisiologia , Ouabaína/farmacologia , Coelhos , ATPase Trocadora de Sódio-Potássio/antagonistas & inibidores , Tetraetilamônio/farmacologia , Fatores de Tempo , Vasoconstritores/farmacologia
20.
Arch Int Pharmacodyn Ther ; 262(2): 215-20, 1983 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-6135398

RESUMO

A simple and rapid method is described for the screening of narcotic and non-narcotic analgesics in conscious rabbits. This method is based upon the increase in threshold by electrical stimulation of the ears of rabbit, by analgesics. A reliable dose-response and time-response relations were observed for both groups of analgesics. Naloxone did not produce a hyperalgesia when given alone. It antagonized, however, the analgesic activity of morphine without altering that of aspirin. From these results it is concluded that nociception induced by electrical stimulation of rabbit ears is a simple and rapid method for the screening of analgesics as well as their interactions with specific antagonists.


Assuntos
Analgésicos Opioides/farmacologia , Anti-Inflamatórios não Esteroides/farmacologia , Avaliação Pré-Clínica de Medicamentos/métodos , Animais , Aspirina/farmacologia , Relação Dose-Resposta a Droga , Interações Medicamentosas , Estimulação Elétrica , Feminino , Cobaias , Masculino , Camundongos , Morfina/farmacologia , Naloxona/farmacologia , Nociceptores/efeitos dos fármacos , Nociceptores/fisiologia , Coelhos , Ratos , Especificidade da Espécie
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