Detalhe da pesquisa
1.
Discovery of fluorobenzimidazole HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 26(22): 5462-5467, 2016 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27780635
2.
A (14)C-leucine absorption, distribution, metabolism and excretion (ADME) study in adult Sprague-Dawley rat reveals ß-hydroxy-ß-methylbutyrate as a metabolite.
Amino Acids
; 47(5): 917-24, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25618754
3.
High potency improvements to weak aryl uracil HCV polymerase inhibitor leads.
Bioorg Med Chem Lett
; 23(15): 4367-9, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23791079
4.
Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif.
Bioorg Med Chem Lett
; 23(12): 3487-90, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23664214
5.
Novel hepatitis C virus replicon inhibitors: synthesis and structure-activity relationships of fused pyrimidine derivatives.
Bioorg Med Chem Lett
; 22(6): 2212-5, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22342631
6.
Hepatitis C NS5B polymerase inhibitors: functional equivalents for the benzothiadiazine moiety.
Bioorg Med Chem Lett
; 21(6): 1876-9, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316235
7.
Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor.
J Med Chem
; 51(3): 380-3, 2008 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18183944
8.
Hepatitis C NS5B polymerase inhibitors: 4,4-Dialkyl-1-hydroxy-3-oxo-3,4-dihydronaphthalene-3-yl benzothiadiazine derivatives.
Bioorg Med Chem Lett
; 18(14): 3887-90, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18599294
9.
Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability.
J Med Chem
; 61(3): 1153-1163, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29342358
10.
Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530).
J Med Chem
; 61(9): 4052-4066, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29653491
11.
Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors.
J Med Chem
; 50(8): 1983-7, 2007 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17367123
12.
N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications.
J Med Chem
; 50(5): 1078-82, 2007 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-17298049
13.
Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
J Med Chem
; 50(1): 149-64, 2007 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17201418
14.
Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors.
J Med Chem
; 50(13): 3086-100, 2007 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17530838
15.
Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 49(22): 6439-42, 2006 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17064063
16.
Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists.
J Med Chem
; 49(15): 4459-69, 2006 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-16854051
17.
2,4-diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists.
J Med Chem
; 49(8): 2568-78, 2006 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16610800
18.
Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.
J Med Chem
; 49(12): 3520-35, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16759095
19.
Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.
J Med Chem
; 49(21): 6416-20, 2006 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17034148
20.
Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production.
Metabolism
; 55(9): 1255-62, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16919547