Detalhe da pesquisa
1.
A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH.
N Engl J Med
; 385(17): 1547-1558, 2021 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34670042
2.
Pan-PPAR agonist lanifibranor improves portal hypertension and hepatic fibrosis in experimental advanced chronic liver disease.
J Hepatol
; 74(5): 1188-1199, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33278455
3.
Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active RORγ inverse agonists.
Bioorg Med Chem Lett
; 29(14): 1799-1806, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31101472
4.
Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension.
Ann Rheum Dis
; 76(11): 1931-1940, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28801346
5.
Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis.
Ann Rheum Dis
; 75(12): 2175-2183, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26961294
6.
The pan-PPAR agonist lanifibranor improves cardiometabolic health in patients with metabolic dysfunction-associated steatohepatitis.
Nat Commun
; 15(1): 3962, 2024 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38730247
7.
Biomarkers of Glycosaminoglycans (GAG) accumulation in patients with mucopolysaccharidosis type VI-LeukoGAG, Corneal Opacification (COM) and Carotid Intima Media Thickening (CIMT).
Mol Genet Metab Rep
; 38: 101041, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38234862
8.
Reduction of lysosome abundance and GAG accumulation after odiparcil treatment in MPS I and MPS VI models.
Mol Genet Metab Rep
; 37: 101011, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38053941
9.
CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas.
Nat Commun
; 13(1): 3739, 2022 06 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35768432
10.
The pan-PPAR agonist lanifibranor reduces development of lung fibrosis and attenuates cardiorespiratory manifestations in a transgenic mouse model of systemic sclerosis.
Arthritis Res Ther
; 23(1): 234, 2021 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34488870
11.
WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: a novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity.
J Pharmacol Exp Ther
; 332(1): 190-201, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19828876
12.
Odiparcil, a potential glycosaminoglycans clearance therapy in mucopolysaccharidosis VI-Evidence from in vitro and in vivo models.
PLoS One
; 15(5): e0233032, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32413051
13.
Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate.
J Med Chem
; 61(6): 2246-2265, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29446942
14.
Author Correction: CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas.
Nat Commun
; 14(1): 3127, 2023 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37253849
15.
The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis.
Hepatol Commun
; 1(6): 524-537, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29404476
16.
Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats.
Diabetes
; 51(5): 1461-9, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-11978643
17.
Biodegradable PLGA microparticles for sustained release of a new GnRH antagonist: part II. In vivo performance.
Eur J Pharm Biopharm
; 57(3): 441-6, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15093591
18.
Rapid suppression of plasma testosterone levels and tumor growth in the dunning rat model treated with degarelix, a new gonadotropin-releasing hormone antagonist.
J Pharmacol Exp Ther
; 320(3): 1113-8, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17179469
19.
Pharmacological profile of a new, potent, and long-acting gonadotropin-releasing hormone antagonist: degarelix.
J Pharmacol Exp Ther
; 301(1): 95-102, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11907162