Detalhe da pesquisa
1.
Exploration of a Nitromethane-Carbonylation Strategy during Route Design of an Atropisomeric KRASG12C Inhibitor.
J Org Chem
; 87(4): 2075-2086, 2022 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34652911
2.
Solubility prediction from first principles: a density of states approach.
Phys Chem Chem Phys
; 20(32): 20981-20987, 2018 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30070281
3.
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology.
J Med Chem
; 66(1): 384-397, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36525250
4.
The Global Characterisation of a Drug-Dendrimer Conjugate - PEGylated poly-lysine Dendrimer.
J Pharm Sci
; 112(3): 844-858, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36372229
5.
Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor.
Bioorg Med Chem Lett
; 22(12): 4163-8, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22607682
6.
Machine learning meets mechanistic modelling for accurate prediction of experimental activation energies.
Chem Sci
; 12(3): 1163-1175, 2021 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36299676
7.
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
Bioorg Med Chem
; 18(21): 7486-96, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20869876
8.
Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo.
Bioorg Med Chem Lett
; 19(23): 6670-4, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19854647
9.
Tricyclic Indazoles-A Novel Class of Selective Estrogen Receptor Degrader Antagonists.
J Med Chem
; 62(3): 1593-1608, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30640465
10.
Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable.
Bioorg Med Chem Lett
; 18(16): 4723-6, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18676144
11.
AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models.
Cancer Res
; 76(11): 3307-18, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27020862
12.
Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
J Med Chem
; 58(20): 8128-40, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26407012
13.
Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.
J Med Chem
; 56(5): 2059-73, 2013 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23394218
14.
Automated QSAR with a Hierarchy of Global and Local Models.
Mol Inform
; 30(11-12): 960-72, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27468151
15.
Scaffold hopping using clique detection applied to reduced graphs.
J Chem Inf Model
; 46(2): 503-11, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16562978