Detalhe da pesquisa
1.
Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing.
J Am Chem Soc
; 142(19): 8706-8727, 2020 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32364710
2.
The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems.
J Org Chem
; 81(9): 3509-19, 2016 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27056793
3.
Development of a selective activity-based probe for glycosylated LIPA.
Bioorg Med Chem Lett
; 26(8): 1993-6, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26965858
4.
Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg Med Chem Lett
; 25(22): 5352-6, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26411795
5.
Reactive metabolite trapping studies on imidazo- and 2-methylimidazo[2,1-b]thiazole-based inverse agonists of the ghrelin receptor.
Drug Metab Dispos
; 41(7): 1375-88, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23610086
6.
Synthesis of 7-oxo-dihydrospiro[indazole-5,4'-piperidine] acetyl-CoA carboxylase inhibitors.
J Org Chem
; 77(3): 1497-506, 2012 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22239115
7.
Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor.
Bioorg Med Chem Lett
; 22(13): 4281-7, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22677316
8.
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.
J Med Chem
; 65(22): 15000-15013, 2022 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36322383
9.
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.
J Med Chem
; 64(1): 326-342, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33356244
10.
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.
J Med Chem
; 63(19): 10879-10896, 2020 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32809824
11.
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J Med Chem
; 61(6): 2372-2383, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29466005
12.
Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.
J Med Chem
; 59(3): 1165-75, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26734723
13.
Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5).
Sci Rep
; 5: 17391, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26620127
14.
Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).
J Med Chem
; 58(18): 7173-85, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26349027
15.
Three-component, stereoselective palladium-catalyzed synthesis of functionalized bicyclopentanoids.
Org Lett
; 6(23): 4343-5, 2004 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-15524479
16.
Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.
Structure
; 22(8): 1161-1172, 2014 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25066137
17.
Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example.
ACS Med Chem Lett
; 4(11): 1079-84, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900608
18.
New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett
; 15(21): 4770-3, 2005 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16115768