Detalhe da pesquisa
1.
Synthesis and anti-HCV activity of ß-d-2'-deoxy-2'-α-chloro-2'-ß-fluoro and ß-d-2'-deoxy-2'-α-bromo-2'-ß-fluoro nucleosides and their phosphoramidate prodrugs.
Bioorg Med Chem
; 27(4): 664-676, 2019 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30655167
2.
Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase.
Antimicrob Agents Chemother
; 61(8)2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28559253
3.
Synthesis of (2S)-2-Chloro-2-fluororibolactone via Stereoselective Electrophilic Fluorination.
J Org Chem
; 82(24): 13171-13178, 2017 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29140703
4.
Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors.
Bioorg Med Chem Lett
; 27(4): 904-910, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28094179
5.
Synthesis and anti-HCV activity of a series of ß-d-2'-deoxy-2'-dibromo nucleosides and their corresponding phosphoramidate prodrugs.
Bioorg Med Chem Lett
; 27(23): 5296-5299, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29066308
6.
Synthesis and antiviral evaluation of 2',2',3',3'-tetrafluoro nucleoside analogs.
Tetrahedron Lett
; 58(7): 642-644, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28163339
7.
Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.
Antimicrob Agents Chemother
; 60(8): 4659-69, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27216050
8.
Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors.
Bioorg Med Chem Lett
; 25(17): 3711-5, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26099532
9.
Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases.
Tetrahedron Lett
; 56(23): 3587-3590, 2015 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26028788
10.
Synthesis and antiviral evaluation of 2',3'-dideoxy-2',3'-difluoro-D-arabinofuranosyl 2,6-disubstituted purine nucleosides.
Heterocycl Comm
; 21(5): 315-327, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-34316093
11.
Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs.
Bioorg Med Chem
; 22(23): 6665-6671, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25458500
12.
Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs.
Nucleic Acids Res
; 40(1): 381-90, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21914723
13.
Synthesis of cyclopentanyl carbocyclic 5-fluorocytosine ((-)-5-fluorocarbodine) using a facially selective hydrogenation approach.
J Org Chem
; 78(2): 723-7, 2013 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23231055
14.
Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 23(11): 3385-8, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23623492
15.
Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 23(7): 2031-4, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23466233
16.
Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors.
Bioorg Med Chem Lett
; 23(23): 6325-30, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24135727
17.
Synthesis and evaluation of novel potent HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 22(14): 4864-8, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22704887
18.
Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 22(10): 3488-91, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22507961
19.
Scaleable processes for the synthesis of (-)-ß-D-2,6-diaminopurine dioxolane (Amdoxovir, DAPD) and (-)-ß-D-2-aminopurine dioxolane (APD).
Tetrahedron
; 68(29): 5738-5743, 2012 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23162170
20.
HIV nucleoside reverse transcriptase inhibitors.
Eur J Med Chem
; 240: 114554, 2022 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35792384