Detalhe da pesquisa
1.
Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases.
Bioorg Med Chem Lett
; 28(8): 1336-1341, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29559278
2.
AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia.
Blood
; 123(6): 905-13, 2014 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24363397
3.
Discovery, design, and synthesis of indole-based EZH2 inhibitors.
Bioorg Med Chem Lett
; 25(17): 3644-9, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26189078
4.
Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507.
Bioorg Med Chem Lett
; 23(16): 4591-6, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23842474
5.
Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO.
Bioorg Med Chem Lett
; 22(14): 4907-11, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22704236
6.
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases.
Bioorg Med Chem Lett
; 22(14): 4599-604, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22727640
7.
3-amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor.
Bioorg Med Chem Lett
; 21(5): 1382-4, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21295474
8.
3-amido-4-anilinoquinolines as CSF-1R kinase inhibitors 2: Optimization of the PK profile.
Bioorg Med Chem Lett
; 19(3): 701-5, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19114305
9.
Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity.
Bioorg Med Chem Lett
; 19(3): 1026-9, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19097792
10.
Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer.
Bioorg Med Chem Lett
; 18(17): 4794-7, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18694641
11.
Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter.
J Med Chem
; 50(2): 219-32, 2007 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-17228864
12.
Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
J Med Chem
; 59(21): 9928-9941, 2016 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27739677
13.
Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.
J Med Chem
; 59(11): 5391-402, 2016 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27219867
14.
Enantioselective [4 + 2]-annulation of chiral crotylsilanes: application to the synthesis of a C1-C22 fragment of leucascandrolide A.
Org Lett
; 5(21): 3995-8, 2003 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-14535762
15.
Sonogashira coupling of functionalized trifloyl oxazoles and thiazoles with terminal alkynes: synthesis of disubstituted heterocycles.
Org Lett
; 4(15): 2485-8, 2002 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-12123357
16.
A mild, chemoselective protocol for the removal of thioketals and thioacetals mediated by Dess-Martin periodinane.
Org Lett
; 5(4): 575-8, 2003 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12583773
17.
A practical synthesis of indoles via a Pd-catalyzed C-N ring formation.
Org Lett
; 16(16): 4114-7, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25068576
18.
EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation.
Chem Biol
; 21(11): 1463-75, 2014 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25457180
19.
Structure- and reactivity-based development of covalent inhibitors of the activating and gatekeeper mutant forms of the epidermal growth factor receptor (EGFR).
J Med Chem
; 56(17): 7025-48, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23930994
20.
[4 + 2]-annulations of chiral organosilanes: Application to the total synthesis of leucascandrolide A.
J Org Chem
; 72(1): 2-24, 2007 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17194076