Detalhe da pesquisa
1.
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
Mol Cell
; 81(21): 4509-4526.e10, 2021 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34560002
2.
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis.
Cell
; 152(3): 599-611, 2013 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-23374352
3.
Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance.
Immunity
; 49(6): 1132-1147.e7, 2018 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30552022
4.
K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells.
Mol Cell
; 51(3): 283-96, 2013 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23911927
5.
NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly.
J Hepatol
; 72(6): 1182-1195, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32105670
6.
p62 is a key regulator of nutrient sensing in the mTORC1 pathway.
Mol Cell
; 44(1): 134-46, 2011 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21981924
7.
Assessing eco-efficiency and the determinants of horticultural family-farming in southeast Spain.
J Environ Manage
; 204(Pt 1): 594-604, 2017 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28942190
8.
Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation.
Proc Natl Acad Sci U S A
; 108(24): 9957-62, 2011 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21653884
9.
Whole-mount staining of mouse colorectal cancer organoids and fibroblast-organoid co-cultures.
STAR Protoc
; 4(2): 102243, 2023 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37083323
10.
Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer.
Cancer Cell
; 41(2): 252-271.e9, 2023 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36525970
11.
Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.
Nat Commun
; 14(1): 8075, 2023 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38092754
12.
THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer.
Nat Commun
; 14(1): 5534, 2023 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37749092
13.
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis.
EMBO J
; 27(16): 2181-93, 2008 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-18650932
14.
A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis.
EMBO Rep
; 11(3): 226-32, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20154642
15.
Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivo.
Proc Natl Acad Sci U S A
; 106(4): 1099-104, 2009 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19144923
16.
Protein kinase Cλ/ι in cancer: a contextual balance of time and signals.
Trends Cell Biol
; 32(12): 1023-1034, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35501226
17.
Air-liquid organotypic assays to investigate cellular crosstalk in the tumor microenvironment of cancer cells.
STAR Protoc
; 3(3): 101635, 2022 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36035805
18.
The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62.
Cell Rep
; 39(6): 110792, 2022 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35545049
19.
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.
Cell Metab
; 3(3): 211-22, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16517408
20.
NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ.
Nat Commun
; 12(1): 2876, 2021 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34001883