Detalhe da pesquisa
1.
Repurposing the Ionophore, PBT2, for Treatment of Multidrug-Resistant Neisseria gonorrhoeae Infections.
Antimicrob Agents Chemother
; 66(9): e0231821, 2022 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35980187
2.
A drug candidate for Alzheimer's and Huntington's disease, PBT2, can be repurposed to render Neisseria gonorrhoeae susceptible to natural cationic antimicrobial peptides.
J Antimicrob Chemother
; 76(11): 2850-2853, 2021 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34450628
3.
Selective Targeting of Breast Cancer by Tafuramycin A Using SMA-Nanoassemblies.
Molecules
; 26(12)2021 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34207832
4.
The catalytic mechanism of human parainfluenza virus typeâ 3 haemagglutinin-neuraminidase revealed.
Angew Chem Int Ed Engl
; 54(10): 2936-40, 2015 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25676091
5.
A versatile synthesis of "tafuramycin A": a potent anticancer and parasite attenuating agent.
Org Biomol Chem
; 12(24): 4260-4, 2014 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24838868
6.
Neurodegenerative Disease Treatment Drug PBT2 Breaks Intrinsic Polymyxin Resistance in Gram-Positive Bacteria.
Antibiotics (Basel)
; 11(4)2022 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35453201
7.
Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model.
Cell Rep
; 38(2): 110202, 2022 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35021083
8.
Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection.
mBio
; 13(1): e0351721, 2022 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35012353
9.
A novel potential therapeutic avenue for autism: design, synthesis and pharmacophore generation of SSRIs with dual action.
Bioorg Med Chem Lett
; 21(22): 6714-23, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21982496
10.
Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin.
Pharmaceuticals (Basel)
; 15(1)2021 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35056083
11.
Transcriptomic Data Sets To Determine Gene Expression Changes Mediated by the Presence of PBT2 in Growth Medium of Multidrug-Resistant Neisseria gonorrhoeae WHO Z.
Microbiol Resour Announc
; 9(21)2020 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32439664
12.
Neisseria gonorrhoeae Becomes Susceptible to Polymyxin B and Colistin in the Presence of PBT2.
ACS Infect Dis
; 6(1): 50-55, 2020 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31697892
13.
Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2.
mSphere
; 5(2)2020 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32188750
14.
Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis.
Sci Transl Med
; 12(570)2020 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33208501
15.
Design, synthesis, screening, and molecular modeling study of a new series of ROS1 receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett
; 19(19): 5622-6, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19700314
16.
Design, synthesis and biological evaluation of new potent and highly selective ROS1-tyrosine kinase inhibitor.
Bioorg Med Chem Lett
; 19(16): 4720-3, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19596575
17.
Targeting Human Parainfluenza Virus Type-1 Haemagglutinin-Neuraminidase with Mechanism-Based Inhibitors.
Viruses
; 11(5)2019 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31060278
18.
Design and synthesis of novel phenylaminopyrimidines with antiproliferative activity against colorectal cancer.
RSC Adv
; 9(37): 21578-21586, 2019 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35521305
19.
New antiviral approaches for human parainfluenza: Inhibiting the haemagglutinin-neuraminidase.
Antiviral Res
; 167: 89-97, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30951732
20.
Curcuminâ»Copper Complex Nanoparticles for the Management of Triple-Negative Breast Cancer.
Nanomaterials (Basel)
; 8(11)2018 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30388728