Detalhe da pesquisa
1.
MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.
FASEB J
; 29(5): 1817-29, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25636740
2.
Design and synthesis of calindol derivatives as potent and selective calcium sensing receptor agonists.
Bioorg Med Chem
; 24(4): 554-69, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26752095
3.
Characterization of Sonic Hedgehog transcripts in the adult mouse brain: co-expression with neuronal and oligodendroglial markers.
Brain Struct Funct
; 229(3): 705-727, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38329543
4.
Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened.
Mol Pharmacol
; 83(5): 1020-9, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23448715
5.
[Structure of the Smoothened receptor]. / Structure du récepteur Smoothened.
Med Sci (Paris)
; 29(10): 855-60, 2013 Oct.
Artigo
em Francês
| MEDLINE | ID: mdl-24148123
6.
Facilitating Prospective Registration of Diagnostic Accuracy Studies: A STARD Initiative.
Clin Chem
; 63(8): 1331-1341, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28630237
7.
Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist.
Mol Pharmacol
; 79(3): 453-60, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21177415
8.
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.
Bioorg Med Chem Lett
; 21(12): 3608-12, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21592788
9.
Smoothened/AMP-Activated Protein Kinase Signaling in Oligodendroglial Cell Maturation.
Front Cell Neurosci
; 15: 801704, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-35082605
10.
Sonic Hedgehog receptor Patched deficiency in astrocytes enhances glucose metabolism in mice.
Mol Metab
; 47: 101172, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33513436
11.
Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists.
Mol Pharmacol
; 78(4): 658-65, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20664000
12.
Design and synthesis of cyclic sulfonamides and sulfamates as new calcium sensing receptor agonists.
Bioorg Med Chem Lett
; 20(24): 7483-7, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21041081
13.
C9C5 positive mature oligodendrocytes are a source of Sonic Hedgehog in the mouse brain.
PLoS One
; 15(2): e0229362, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32078657
14.
Evidence for the presence of GPRC6A receptors in rat mesenteric arteries.
Cell Calcium
; 44(2): 210-9, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18221783
15.
Distribution of Smoothened at hippocampal mossy fiber synapses.
Neuroreport
; 18(4): 395-9, 2007 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17435610
16.
Sharing and reuse of individual participant data from clinical trials: principles and recommendations.
BMJ Open
; 7(12): e018647, 2017 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29247106
17.
N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity.
J Med Chem
; 49(17): 5119-28, 2006 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-16913701
18.
Hedgehog Controls Quiescence and Activation of Neural Stem Cells in the Adult Ventricular-Subventricular Zone.
Stem Cell Reports
; 7(4): 735-748, 2016 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27666792
19.
Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives.
Eur J Med Chem
; 121: 747-757, 2016 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27429255
20.
Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway.
Sci Rep
; 6: 23479, 2016 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27010359