Detalhe da pesquisa
1.
RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4.
Immunity
; 45(1): 46-59, 2016 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27396959
2.
RIP3 induces apoptosis independent of pronecrotic kinase activity.
Mol Cell
; 56(4): 481-95, 2014 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25459880
3.
Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis.
Stroke
; 48(4): 1033-1043, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28250197
4.
Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.
J Immunol
; 192(12): 5476-80, 2014 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24821972
5.
Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity.
J Biol Chem
; 287(30): 25030-7, 2012 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22665479
6.
Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.
ACS Med Chem Lett
; 10(6): 857-862, 2019 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31223438
7.
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
J Med Chem
; 62(10): 5096-5110, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31013427
8.
Identification of testis-specific male contraceptive targets: insights from transcriptional profiling of the cycle of the rat seminiferous epithelium and purified testicular cells.
Ann N Y Acad Sci
; 1120: 36-46, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18184910
9.
Gene expression during development of fetal and adult Leydig cells.
Ann N Y Acad Sci
; 1120: 16-35, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18184909
10.
Identification of epididymis-specific transcripts in the mouse and rat by transcriptional profiling.
Asian J Androl
; 9(4): 522-7, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17589790
11.
Segment boundaries of the adult rat epididymis limit interstitial signaling by potential paracrine factors and segments lose differential gene expression after efferent duct ligation.
Asian J Androl
; 9(4): 565-73, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17589796
12.
Identification of an antibody-based immunoassay for measuring direct target binding of RIPK1 inhibitors in cells and tissues.
Pharmacol Res Perspect
; 5(6)2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29226625
13.
Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers.
Pharmacol Res Perspect
; 5(6)2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29226626
14.
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
J Med Chem
; 60(4): 1247-1261, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28151659
15.
DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
J Med Chem
; 59(5): 2163-78, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26854747
16.
The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.
J Med Chem
; 59(10): 4867-80, 2016 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27109867
17.
Herpes simplex virus suppresses necroptosis in human cells.
Cell Host Microbe
; 17(2): 243-51, 2015 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25674983
18.
MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses.
PLoS One
; 10(5): e0127083, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25965667
19.
Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis.
ACS Med Chem Lett
; 4(12): 1238-43, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900635
20.
Differential gene expression among the proximal segments of the rat epididymis is lost after efferent duct ligation.
Biol Reprod
; 77(1): 165-71, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17377138