Detalhe da pesquisa
1.
10-Hydroxy-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants.
Bioorg Med Chem Lett
; 18(16): 4581-3, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18657970
2.
8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 17(23): 6511-5, 2007 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17931865
3.
Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
J Med Chem
; 46(4): 453-6, 2003 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12570367
4.
Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 17(20): 5595-9, 2007 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17822898
5.
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.
Proc Natl Acad Sci U S A
; 101(31): 11233-8, 2004 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15277684