RESUMO
BACKGROUND: Blood operators screen donors to reduce the risk of transfusion-transmitted infections (TTIs). Many are evolving screening procedures from those that defer all who have had a sexual interaction with gay, bisexual, or other men who have sex with men (gbMSM) to an approach that assesses individual donors' recent sexual risk behavior with any partner. STUDY DESIGN AND METHODS: A representative sample of current blood donors (N = 1194) was recruited online and randomized to complete either the existing (at the time of the study) Canadian Blood Services' donor questionnaire (DQ) that screens out those with recent gbMSM sexual experience, a modified donor questionnaire (MDQ) that assesses individuals' recent sexual behavior with any partner, or an MDQ that assesses individual sexual behavior with any partner and explains why these questions are asked. Respondents were asked for their perceptions concerning difficulty, comfort, and acceptability of these screening questionnaires. RESULTS: Across experimental conditions, current donors regarded screening questionnaire difficulty to be low; discomfort in responding was minimal; screening questionnaires were perceived to be relatively inoffensive and justified, and very few donors would cease donating if the screening questionnaire they responded to became the one in general use. Some minor sex differences were observed, and in some cases, perceptions of the MDQ with explanation were somewhat more positive than those of the DQ and MDQ without explanation. DISCUSSION: An individual risk behavior screening approach appears to be acceptable to current blood donors as an alternative to screening out all who have recently engaged in gbMSM sexual interactions.
Assuntos
Infecções por HIV , Minorias Sexuais e de Gênero , Humanos , Masculino , Feminino , Homossexualidade Masculina , Doadores de Sangue , Infecções por HIV/diagnóstico , Infecções por HIV/epidemiologia , Infecções por HIV/prevenção & controle , Canadá , Comportamento Sexual , Assunção de RiscosRESUMO
BACKGROUND: Canadian Blood Services (CBS) screens donors based on group status (e.g., men who have sex with men, MSM) instead of specific, high-risk sexual practices (e.g., occurrence of condomless sex). The MSM screening question is embedded in a cluster of questions about stigmatized attributes such as history of imprisonment and illicit substance use. This juxtaposition of the "MSM question" and stigmatized attributes may unintentionally cause blood donors to perceive MSM more negatively. The aim of this research is to determine whether the CBS donor eligibility questionnaire generates negative bias against MSM. STUDY DESIGN AND METHODS: A national, randomized online study of 903 CBS donors was conducted. Participants completed either the existing blood donor eligibility questionnaire or a modified donor questionnaire that repositioned the MSM question among neutral questions. After completing the existing or modified questionnaire, bias against MSM was measured using the sexuality implicit association test (IAT) and Modern Homonegativity Scale - Gay Men (MHS-G). Lastly, participants estimated prevalence rates among MSM of certain stigmatized behaviors. RESULTS: Participants who completed the existing donor eligibility questionnaire more strongly associated gay men with negative attributes on the IAT (pone-tailed = .045), suggesting question position generated implicit negative bias toward MSM. Responses to the MHS-G (pone-tailed = .506) and prevalence estimation task (p = .443) indicated that question order had no significant impact on explicit bias. DISCUSSION: Positioning the MSM screening question among stigmatizing questions creates implicit negative bias against MSM. Policy makers should be mindful of question positioning when designing donor questionnaires.
Assuntos
Infecções por HIV , Minorias Sexuais e de Gênero , Canadá/epidemiologia , Seleção do Doador , Infecções por HIV/epidemiologia , Homossexualidade Masculina , Humanos , Masculino , Assunção de Riscos , Comportamento Sexual , Inquéritos e QuestionáriosRESUMO
OBJECTIVE: To provide guidance on culturally competent contraception counselling that is free of coercion and promotes shared decision-making and patient autonomy. TARGET POPULATION: Individuals of reproductive age who seek contraception or counselling for family planning. OPTIONS: Contraception counselling is provided within a rights-based family planning framework, where the individual's beliefs, culture, preferences, and ability to use the chosen method are respected. OUTCOMES: To promote patient autonomy in decision-making surrounding family planning, including the right to access and use their contraceptive method of choice, to decline contraception or use less effective methods of contraception, and to freely choose to discontinue a method of contraception, as well as the right to unbiased, non-coercive contraception counselling and evidence-based information from their health care provider BENEFITS, HARMS, AND COSTS: Implementation of these recommendations would reduce real or perceived coercive contraceptive care, particularly among vulnerable populations, resulting in improved patient autonomy and a better patient experience in health care settings. EVIDENCE: Databases searched: MEDLINE, Cochrane, PubMed, and CanLII. Medical terms used: contraception, family planning services, informed consent, coercion, decision making, sterilization, permanent contraception, counselling. Legal terms searched: forced sterilization, and aboriginal. Initial search conducted in 2020 and updated in 2021. INTENDED AUDIENCE: This committee opinion is intended for health care providers (obstetricians, gynaecologists, family physicians, general surgeons, nurse practitioners, nurses, midwives, undergraduate/postgraduate medical trainees, and other health care providers) who provide sexual and reproductive health services.
Assuntos
Coerção , Anticoncepcionais , Anticoncepção , Aconselhamento , Serviços de Planejamento Familiar , HumanosRESUMO
INTRODUCTION: With the emergence of rapidly expanding access to sexually explicit materials, research concerning pornography prevalence, pornography content, pornography users, and pornography effects has increased steadily among scientists and clinicians. Findings in this research area are often inconsistent and controversial. AIM: The current discussion aims to assist scientists and clinicians to "read pornography-that is, pornography research-" from an appropriately rigorous scientific perspective, so that we may approach work in this area with a clearer understanding of the often contested evidence base and a clearer understanding of what science can, and cannot, tell us, at present, about pornography prevalence, content, users, and effects. METHODS: Discussion focuses on the critical implications, for scientific validity and clinical application, of variations in research design, participant sampling, conceptual and operational definitions of "pornography" and "use," measurement of sexually violent content, and measurement of pornography use effects. RESULTS: Failure to acknowledge the implications of research design limitations and heterogeneity of conceptual and operational definitions of pornography have resulted in an inconsistent and contested evidence base in this area. CLINICAL IMPLICATIONS: Clinicians must rigorously evaluate the published literature concerning pornography, according to classical principles of scientific research, before clinical application of diverse and inconsistent research claims. STRENGTH & LIMITATIONS: This analysis brings to bear classic scientific considerations in attempting to strengthen critical reading and research contributions in the area of pornography prevalence, content, users, correlates, and effects. Many of the assertions and suggestions contained in this discussion await empirical verification. CONCLUSION: Rigorous application of basic scientific research principles should guide the evaluation and conduct of research concerning pornography prevalence, content, users, covariates, and effects. Fisher WA, Kohut T. Reading Pornography: Methodological Considerations in Evaluating Pornography Research. J Sex Med 2020;17:195-209.
Assuntos
Literatura Erótica , Projetos de Pesquisa , Feminino , Humanos , Prevalência , Leitura , Delitos Sexuais , Comportamento SexualRESUMO
OBJECTIVE: The current research focuses on sexual risk behaviour among young adult Canadians who have not been vaccinated against HPV. METHODS: Six hundred and forty-six Canadian university undergraduates completed a self-administered survey assessing HPV vaccination status and sexual risk behaviour. RESULTS: Five hundred and thirty-seven participants (154 men and 383 women aged 17-23) who met eligibility criteria were analyzed. 48.5% (n = 185) of female and 89.6% (n = 138) of male participants had not been vaccinated against HPV. In the unvaccinated cohort, 51.4% (n = 95) of women were coitally experienced, 49.2% (n = 91) reported experience with oral sex, and 6.5% (n = 12) reported experience with receptive anal intercourse. 55.1% (n = 76) of men were coitally experienced, 22.5% (n = 31) of men reported receptive oral sex, and 2.9% (n = 4) of men reported receptive anal intercourse. Using validated sexual risk behaviour cut-offs, we determined that in the female unvaccinated population, the proportion at significantly increased risk for genital warts, cervical, anal, and oropharyngeal cancer was 11.0%, 30.0%, 6.5%, and 49.2% respectively. In the male unvaccinated population, the proportion at significantly elevated risk for genital warts and anal cancer was 27.2% and 2.9% respectively. CONCLUSION: Unvaccinated young Canadian women and men commonly engaged in sexual risk behaviours for HPV infection, engaged in sexual risk behaviours at a similar level as their vaccinated counterparts, and a substantial number were at elevated risk of HPV related morbidities at a young age. Findings contribute to an evidence-based case for redoubling efforts to encourage HPV vaccination among unvaccinated young Canadians who are at risk of HPV infection.
Assuntos
Comportamentos de Risco à Saúde , Vacinas contra Papillomavirus , Comportamento Sexual/estatística & dados numéricos , Vacinação/estatística & dados numéricos , Adolescente , Canadá , Feminino , Humanos , Masculino , Inquéritos e Questionários , Vacinação/psicologia , Adulto JovemRESUMO
The focus of this article, the fourth in the series, Standards for Clinical Trials in Male and Female Sexual Dysfunction, is on aspects of clinical trial design and measurement that are specific to clinical trials for treatments of female sexual dysfunction. Challenges in this area include the limited extent of treatment development and clinical trial research across the spectrum of female sexual dysfunctions, changing regulatory considerations, changing diagnostic criteria for female sexual dysfunction, and the need to articulate assessment procedures to these changes. Discussion focuses on approaches to addressing these challenges in clinical trials in female sexual dysfunction.
Assuntos
Ensaios Clínicos como Assunto/normas , Disfunções Sexuais Fisiológicas/terapia , Disfunções Sexuais Psicogênicas/terapia , Feminino , Humanos , Disfunções Sexuais Psicogênicas/diagnósticoRESUMO
This series of articles, Standards for Clinical Trials in Male and Female Sexual Dysfunction, began with the discussion of a common expected standard for clinical trial design in male and female sexual dysfunction, a common rationale for the design of phase I to IV clinical trials, and common considerations for the selection of study population and study duration in male and female sexual dysfunction. The second article in this series discussed fundamental principles in development, validation, and selection of patient- (and partner-) reported outcome assessment. The third and present article in this series discusses selected aspects of sexual dysfunction that are that are unique to male sexual dysfunctions and relevant to the conduct of clinical trials of candidate treatments for men.
Assuntos
Ensaios Clínicos como Assunto/normas , Disfunções Sexuais Fisiológicas/terapia , Disfunções Sexuais Psicogênicas/terapia , Humanos , Masculino , Avaliação de Resultados em Cuidados de SaúdeRESUMO
The current study adopted a participant-informed, "bottom-up," qualitative approach to identifying perceived effects of pornography on the couple relationship. A large sample (N = 430) of men and women in heterosexual relationships in which pornography was used by at least one partner was recruited through online (e.g., Facebook, Twitter, etc.) and offline (e.g., newspapers, radio, etc.) sources. Participants responded to open-ended questions regarding perceived consequences of pornography use for each couple member and for their relationship in the context of an online survey. In the current sample of respondents, "no negative effects" was the most commonly reported impact of pornography use. Among remaining responses, positive perceived effects of pornography use on couple members and their relationship (e.g., improved sexual communication, more sexual experimentation, enhanced sexual comfort) were reported frequently; negative perceived effects of pornography (e.g., unrealistic expectations, decreased sexual interest in partner, increased insecurity) were also reported, albeit with considerably less frequency. The results of this work suggest new research directions that require more systematic attention.
Assuntos
Literatura Erótica/psicologia , Comportamento Sexual/psicologia , Parceiros Sexuais/psicologia , Cônjuges/psicologia , Cônjuges/estatística & dados numéricos , Adulto , Estudos Transversais , Feminino , Humanos , MasculinoRESUMO
OBJECTIVE: To achieve a comprehensive understanding of patients' adherence to medication following acute coronary syndrome (ACS), we assessed the possible moderating role played by attachment orientation on the effects of attitudes, subjective norms, and perceived behavioral control (PBC), as derived from the Theory of Planned Behavior (TPB; Ajzen, 1991), on intention and reported adherence. METHOD: A prospective longitudinal design was employed. During hospitalization, ACS male patients (N = 106) completed a set of self-report questionnaires including sociodemographic variables, attachment orientation, and measures of TPB constructs. Six months post-discharge, 90 participants completed a questionnaire measuring adherence to medication. RESULTS: Attachment orientations moderated some of the predictions of the TPB model. PBC predicted intention and reported adherence, but these associations were found to be significant only among individuals with lower, as opposed to higher, attachment anxiety. The association between attitudes and intention was stronger among individuals with higher, as opposed to lower, attachment anxiety. Only among individuals with higher attachment avoidance, subjective norms were negatively associated with intention to take medication. CONCLUSIONS: Cognitive variables appear to explain both adherence intention and behavior, but differently, depending on individuals' attachment orientations. Integrating personality and cognitive models may prove effective in understanding patients' health behaviors.
Assuntos
Síndrome Coronariana Aguda/tratamento farmacológico , Comportamentos Relacionados com a Saúde , Adesão à Medicação/psicologia , Apego ao Objeto , Idoso , Seguimentos , Humanos , Intenção , Masculino , Pessoa de Meia-Idade , Teoria PsicológicaRESUMO
This series of articles outlines standards for clinical trials of treatments for male and female sexual dysfunctions, with a focus on research design and patient-reported outcome assessment. These articles consist of revision, updating, and integration of articles on standards for clinical trials in male and female sexual dysfunction from the 2010 International Consultation on Sexual Medicine developed by the authors as part of the 2015 International Consultation on Sexual Medicine. We are guided in this effort by several principles. In contrast to previous versions of these guidelines, we merge discussion of standards for clinical trials in male and female sexual dysfunction in an integrated approach that emphasizes the common foundational practices that underlie clinical trials in the two settings. We present a common expected standard for clinical trial design in male and female sexual dysfunction, a common rationale for the design of phase I to IV clinical trials, and common considerations for selection of study population and study duration in male and female sexual dysfunction. We present a focused discussion of fundamental principles in patient- (and partner-) reported outcome assessment and complete this series of articles with specific discussions of selected aspects of clinical trials that are unique to male and to female sexual dysfunction. Our consideration of standards for clinical trials in male and female sexual dysfunction attempts to embody sensitivity to existing and new regulatory guidance and to address implications of the evolution of the diagnosis of sexual dysfunction that have been brought forward in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. The first article in this series focuses on phase I to phase IV clinical trial design considerations. Subsequent articles in this series focus on the measurement of patient-reported outcomes, unique aspects of clinical trial design for men, and unique aspects of clinical trial design for women.
Assuntos
Ensaios Clínicos como Assunto/normas , Disfunções Sexuais Fisiológicas/terapia , Disfunções Sexuais Psicogênicas/terapia , Manual Diagnóstico e Estatístico de Transtornos Mentais , Feminino , Humanos , Masculino , Avaliação de Resultados em Cuidados de Saúde , Comportamento SexualRESUMO
The second article in this series, Standards for Clinical Trials in Male and Female Sexual Dysfunction, focuses on measurement of patient-reported outcomes (PROs). Together with the design of appropriate phase I to phase IV clinical trials, the development, validation, choice, and implementation of valid PRO measurements-the focus of the present article-form the foundation of research on treatments for male and female sexual dysfunctions. PRO measurements are assessments of any aspect of a patient's health status that come directly from the patient (ie, without the interpretation of the patient's responses by a physician or anyone else). PROs are essential for assessing male and female sexual dysfunction and treatment response, including symptom frequency and severity, personal distress, satisfaction, and other measurements of sexual and general health-related quality of life. Although there are some relatively objective measurements of sexual dysfunction (ie, intravaginal ejaculatory latency time, frequency of sexual activity, etc), these measurements do not comprehensively assess the occurrence and extent of sexual dysfunction or treatment on the patient's symptoms, functioning, and well-being. Data generated by a PRO instrument can provide evidence of a treatment benefit from the patient's perspective.
Assuntos
Ensaios Clínicos como Assunto/normas , Medidas de Resultados Relatados pelo Paciente , Disfunções Sexuais Psicogênicas/terapia , Feminino , Humanos , Masculino , Qualidade de Vida , Comportamento SexualRESUMO
Epidemiologic studies of sexual function problems in men have focused on the individual male and related sociodemographic characteristics, individual risk factors and lifestyle concomitants, or medical comorbidities. Insufficient attention has been given to the role of sexual and relationship satisfaction and, more particularly, to the perspective of the couple as causes or correlates of sexual problems in men or women. Previously, we reported results of the first large, multi-national study of sexual satisfaction and relationship happiness in 1,009 midlife and older couples in five countries (Brazil, Germany, Japan, Spain, U.S.). For the present study, we examined, within each problem, the association of four major sexual problems in men (loss of sexual desire, erectile problems, premature ejaculation, delayed/absent orgasm) and multiple problems, with male and female partners' assessments of physical intimacy, sexual satisfaction, and relationship happiness, as well as associations with well-known health and psychosocial correlates of sexual problems in men. Sexual problem rates of men in our survey were generally similar to rates observed in past surveys in the general population, and similar risk factors (age, relationship duration, overall health) were associated with lack of desire, anorgasmia, or erection difficulties in our sample. As in previous surveys, there were few correlates of premature ejaculation. As predicted, men with one or more sexual problems reported decreased relationship happiness as well as decreased sexual satisfaction compared to men without sexual problems. Moreover, female partners of men with sexual problems had reduced relationship happiness and sexual satisfaction, although these latter outcomes were less affected in the women than the men. The association of men's sexual problems with men's and women's satisfaction and relationship happiness were modest, as these couples in long-term, committed relationships were notable for their relatively high levels of physical affection and relationship happiness.
Assuntos
Disfunção Erétil/psicologia , Orgasmo , Satisfação Pessoal , Ejaculação Precoce/psicologia , Adolescente , Adulto , Características da Família , Feminino , Felicidade , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Comportamento Sexual/psicologia , Disfunções Sexuais Psicogênicas , Parceiros Sexuais/psicologia , Inquéritos e Questionários , Estados Unidos , Adulto JovemRESUMO
The current research reports a dyadic analysis of sexual satisfaction, relationship happiness, and correlates of these couple outcomes in a large multinational dataset consisting of 1,009 midlife heterosexual couples (2,018 individuals) recruited in Japan, Brazil, Germany, Spain, and the United States (Heiman et al., 2011). Actor-Partner Interdependence Models (Kenny, Kashy, & Cook, 2006) identified correlates of sexual satisfaction that included individuals' reports of good health; frequent kissing, cuddling, and caressing; frequent recent sexual activity; attaching importance to one's own and one's partner's orgasm; better sexual functioning; and greater relationship happiness. Even after controlling for individual-level effects, partners' reports of good health; frequent kissing, cuddling, and caressing; frequent recent sexual activity; attaching importance to one's own and one's partner's orgasm; better sexual functioning; and greater relationship happiness contributed significantly to predicting and understanding individuals' sexual satisfaction. Correlates of relationship happiness included individuals' reports of good health; frequent kissing, cuddling, and caressing; frequent recent sexual activity; attaching importance to one's own and one's partner's orgasm; better sexual functioning; and greater sexual satisfaction, and once again, even after controlling for individual-level effects, partners' reports of each of these correlates contributed significantly to predicting and understanding individuals' relationship happiness. Interactions of individual and partner effects with participant gender are also reported. Current results demonstrate empirically that the partner "matters" to an individual's sexual satisfaction and relationship happiness and indicate that a comprehensive understanding of factors contributing to these couple outcomes requires a couple-level research strategy. Partner effects, even when controlling for individual effects, were consistently observed, and explanation of sexual satisfaction and relationship happiness always depended on identifying and understanding mutual and concurrent individual and partner influences.
Assuntos
Heterossexualidade/psicologia , Satisfação Pessoal , Autorrevelação , Comportamento Sexual/psicologia , Parceiros Sexuais/psicologia , Adulto , Brasil , Feminino , Alemanha , Felicidade , Heterossexualidade/estatística & dados numéricos , Humanos , Relações Interpessoais , Japão , Masculino , Pessoa de Meia-Idade , Comportamento Sexual/estatística & dados numéricos , Espanha , Inquéritos e Questionários , Estados UnidosRESUMO
OBJECTIVES: Lack of providers is a barrier to accessing abortion in Canada. The factors influencing the number of abortion providers are poorly understood. In this study, we assessed the attitudes and intentions of medical students towards abortion training and provision to gain insight into the future supply of abortion providers. METHODS: We surveyed first, second, and third year medical students at an Ontario university to determine their intentions to train in and provide abortion services during different stages of training and in future practice. We assessed students' attitudes and intentions towards training in and providing abortions, their perceptions of social support, their perceived ability to receive training in and to provide abortion services, and their attitudes towards the legality of abortion. RESULTS: Surveys were completed by 337 of 508 potential respondents (66.7%). The responses indicated that the students in the survey held relatively positive attitudes towards the legality and availability of abortion in Canada. Respondents had significantly more positive attitudes towards first trimester medical abortions (and a greater intention to provide them) than towards second trimester surgical abortions. Thirty-five percent of students planned to enter a specialty in which they could perform abortions, but fewer than 30% of these students planned to provide any type of abortion. Intentions to provide abortions were correlated with positive attitudes toward abortion in general and greater perceived social support for abortion provision. CONCLUSION: A small proportion of students sampled intended both to enter a specialty in which abortion would be within the scope of practice and to provide abortion services. Lack of perceived social support for providing abortions and the perceived inability to obtain abortion training or to logistically provide abortions were identified as two potentially modifiable barriers to abortion provision. We propose increasing education on abortion provision and creating policies to promote medical abortion as a method of improving access to abortion across Canada.
Objectifs : Au Canada, l'accès à des services d'avortement est entravé par le manque de fournisseurs de soins étant en mesure d'offrir de tels services. Les facteurs qui influencent le nombre de fournisseurs de services d'avortement sont mal compris. Dans le cadre de cette étude, nous avons évalué les attitudes et les intentions des étudiants de médecine en ce qui concerne la formation en matière d'avortement et l'offre de tels services dans le cadre de leur future pratique, et ce, pour en connaître davantage au sujet de nos futurs effectifs dans ce domaine. Méthodes : Nous avons sondé les étudiants de médecine de première, de deuxième et de troisième année d'une université ontarienne, à différents stades de leur formation (et en leur demandant de remplir un questionnaire traitant de la future pratique qu'ils envisageaient), en vue de déterminer leurs intentions en ce qui concerne l'obtention d'une formation en matière d'avortement et l'offre de services d'avortement. Nous avons évalué les attitudes et les intentions de ces étudiants en ce qui concerne l'obtention d'une formation en matière d'avortement et l'offre de services d'avortement, leurs perceptions en ce qui a trait au soutien social, leur capacité subjective de recevoir une formation en matière d'avortement et d'offrir des services d'avortement, et leurs attitudes envers la légalité de l'avortement. Résultats : Trois cent trente-sept des 508 répondants potentiels (66,7 %) ont répondu aux questionnaires. Les réponses indiquent que les répondants adoptaient des attitudes relativement positives envers la légalité et la disponibilité de l'avortement au Canada. Les répondants adoptaient des attitudes considérablement plus positives envers les avortements médicaux au premier trimestre (et un plus grand nombre d'entre eux avaient l'intention d'offrir de tels services) qu'envers les avortements chirurgicaux menés au deuxième trimestre. Trente-cinq pour cent des étudiants avaient l'intention de choisir une spécialité dans le cadre de laquelle latenue d'avortements serait possible; toutefois, moins de 30 % de ces étudiants avaient l'intention d'offrir quelque type de services d'avortement que ce soit. Les intentions d'offrir des services d'avortement étaient en corrélation avec les attitudes positives envers l'avortement en général et avec la perception d'un soutien social accru envers l'offre de services d'avortement. Conclusion : Une faible proportion de l'échantillon d'étudiants analysé avait l'intention de choisir une spécialité dont le champ d'activité englobe la tenue d'avortements et d'offrir des services d'avortement. L'absence subjective de soutien social envers l'offre de services d'avortement et l'incapacité subjective d'obtenir une formation en matière d'avortement ou d'offrir des services d'avortement au plan logistique ont été identifiés comme étant deux obstacles potentiellement modifiables pour ce qui est de l'offre de services d'avortement. Pour assurer l'amélioration de l'accès à l'avortement d'un bout à l'autre du Canada, nous proposons l'augmentation des efforts d'éducation au sujet de l'offre de services d'avortement et la création de politiques visant la promotion de l'avortement médical.
Assuntos
Aborto Induzido/educação , Atitude do Pessoal de Saúde , Estudantes de Medicina/psicologia , Aborto Induzido/psicologia , Aborto Legal/psicologia , Canadá , Feminino , Idade Gestacional , Acessibilidade aos Serviços de Saúde , Humanos , Percepção , Padrões de Prática Médica , Gravidez , Inquéritos e QuestionáriosRESUMO
The aim of this investigation was to identify factors associated with HIV transmission risk behavior among HIV-positive women and men receiving antiretroviral therapy (ART) in KwaZulu-Natal, South Africa. Across 16 clinics, 1,890 HIV+ patients on ART completed a risk-focused audio computer-assisted self-interview upon enrolling in a prevention-with-positives intervention trial. Results demonstrated that 62 % of HIV-positive patients' recent unprotected sexual acts involved HIV-negative or HIV status unknown partners. For HIV-positive women, multivariable correlates of unprotected sex with HIV-negative or HIV status unknown partners were indicative of poor HIV prevention-related information and of sexual partnership-associated behavioral skills barriers. For HIV-positive men, multivariable correlates represented motivational barriers, characterized by negative condom attitudes and the experience of depressive symptomatology, as well as possible underlying information deficits. Findings suggest that interventions addressing gender-specific and culturally-relevant information, motivation, and behavioral skills barriers could help reduce HIV transmission risk behavior among HIV-positive South Africans.
Assuntos
Preservativos/estatística & dados numéricos , Infecções por HIV/prevenção & controle , Comportamento Sexual/psicologia , Estigma Social , Apoio Social , Adulto , Terapia Antirretroviral de Alta Atividade , Contagem de Linfócito CD4 , Estudos Transversais , Aconselhamento Diretivo , Feminino , Infecções por HIV/tratamento farmacológico , Infecções por HIV/psicologia , Infecções por HIV/transmissão , Educação em Saúde , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Disseminação de Informação , Masculino , Motivação , Relações Médico-Paciente , Fatores de Risco , Assunção de Riscos , África do Sul/epidemiologiaRESUMO
High adherence is important in microbicide trials, but no adherence interventions to date have demonstrated empiric improvements in microbicide adherence or effectiveness. Approximately midway during the CAPRISA 004 trial, we implemented a novel adherence intervention (Adherence Support Program-ASP), based on an Information-Motivation-Behavioral Skills model and incorporating a Motivational Interviewing approach. We assessed the impact of the ASP on adherence and tenofovir gel effectiveness using a before-and-after comparison. Of the 889 women in the trial, 774 contributed 486.1 women-years of follow-up pre-ASP and 828 contributed 845.7 women-years of follow-up post-ASP. Median adherence rose from 53.6 % pre-ASP to 66.5 % post-ASP. Detectable tenofovir levels increased from 40.6 % pre-ASP to 62.5 % post-ASP in 64 women who had paired tenofovir drug samples. Gel effectiveness improved post-ASP; HIV incidence in the tenofovir gel arm was 24 % lower pre-ASP compared to 47 % lower post-ASP. Following implementation of the ASP, microbicide adherence improved with a concomitant increase in the effectiveness of tenofovir gel.
Assuntos
Adenina/análogos & derivados , Fármacos Anti-HIV/administração & dosagem , Anti-Infecciosos Locais/administração & dosagem , Infecções por HIV/prevenção & controle , Comportamentos Relacionados com a Saúde , Adesão à Medicação/psicologia , Organofosfonatos/administração & dosagem , Adenina/administração & dosagem , Adulto , Fármacos Anti-HIV/uso terapêutico , Anti-Infecciosos Locais/uso terapêutico , Método Duplo-Cego , Feminino , Géis , Infecções por HIV/epidemiologia , Humanos , Incidência , Adesão à Medicação/estatística & dados numéricos , Modelos Psicológicos , Entrevista Motivacional , Fatores Socioeconômicos , África do Sul/epidemiologia , Tenofovir , Resultado do TratamentoRESUMO
Social and structural factors including HIV stigma are theorized to drive global disparities in HIV prevalence. This study tests whether HIV self-stigma, or experiences of stigma at the individual level, is associated with engagement in unprotected sex among people living with HIV (PLWH) in KwaZulu-Natal, South Africa, where 37.4% of adults are living with HIV compared with 0.8% worldwide. It further explores whether depressive symptoms, HIV status disclosure to sex partners, and/or condom use attitudes mediate potential associations between HIV self-stigma and unprotected sex. Participants, including 924 PLWH, were recruited from primary care clinics and completed baseline, 6-, 12-, and 18-month survey assessments between 2008 and 2011. Hierarchical linear modeling analyses were used to examine longitudinal within-subjects associations between HIV self-stigma, mediators, and unprotected sex with both HIV-negative/unknown and HIV-positive partners. Results demonstrate that HIV self-stigma was prospectively associated with greater likelihood of unprotected sex with HIV-negative/unknown partners. None of the variables explored significantly mediated this association. HIV self-stigma was also prospectively associated with greater likelihood of unprotected sex with HIV-positive partners via the mediators of greater depressive symptoms and more negative condom use attitudes. The current study suggests that HIV self-stigma undermines HIV secondary prevention and care efforts among PLWH in KwaZulu-Natal. It is therefore critical to address HIV stigma at the social/structural level to reduce HIV self-stigma at the individual level and ultimately curb global disparities in HIV prevalence. In the absence of widespread social/structural change, interventions that treat depressive symptoms and encourage more positive condom use attitudes despite the existence of HIV stigma may buffer associations between HIV self-stigma and unprotected sex with HIV-positive partners among PLWH in KwaZulu-Natal.
Assuntos
Preservativos/estatística & dados numéricos , Depressão/epidemiologia , Infecções por HIV/epidemiologia , Projetos de Pesquisa , Estigma Social , Apoio Social , Sexo sem Proteção/estatística & dados numéricos , Adulto , Depressão/prevenção & controle , Feminino , Infecções por HIV/prevenção & controle , Infecções por HIV/psicologia , Conhecimentos, Atitudes e Prática em Saúde , Inquéritos Epidemiológicos , Humanos , Estudos Longitudinais , Masculino , Pobreza , Prevalência , Fatores de Risco , Parceiros Sexuais , África do Sul/epidemiologia , Inquéritos e QuestionáriosRESUMO
This research tested Confluence Model reasoning that pornography use should be related to sexual aggression among men who are high but not low in the predisposing risk factors of hostile masculinity (HM) and impersonal sexuality (IS). This hypothesis was examined with three online surveys of young adult males, including an American Mechanical Turk sample (N1 = 1,528, Mage = 22.46 years); a national sample of Canadian students (N2 = 1,049, Mage = 20.89 years); and a national sample of Canadian non-students (N3 = 905, Mage = 21.66 years). As expected, synergistic interactions between HM and IS reliably predicted self-reported sexual aggression across samples. Results with respect to interactions with pornography use were more complex. The Confluence Model hypothesis was supported when pornography use was operationalized as the use of nine specific magazines but it was not supported when pornography use was operationalized with a contemporary inclusive approach that included use of internet materials. These discrepant findings are difficult to account for with Confluence Model theorizing and highlight the non-equivalence of pornography use measures in survey research.