Detalhe da pesquisa
1.
Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.
PLoS Pathog
; 14(2): e1006850, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29425238
2.
Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT).
Bioorg Med Chem Lett
; 28(1): 6-10, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29169674
3.
Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob Agents Chemother
; 60(10): 5817-27, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27431220
4.
Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase.
Antimicrob Agents Chemother
; 60(8): 4886-95, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27270277
5.
Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.
Antimicrob Agents Chemother
; 57(3): 1394-403, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23295920
6.
Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novel benzoxaborole.
J Pharmacol Exp Ther
; 344(2): 436-46, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23192653
7.
Discovery and structure-activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents.
Bioorg Med Chem Lett
; 23(21): 5870-3, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24075731
8.
Structure-activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent.
Bioorg Med Chem Lett
; 23(6): 1680-3, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23411072
9.
Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.
Bioorg Med Chem Lett
; 22(3): 1299-307, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22243961
10.
Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents.
Bioorg Med Chem Lett
; 21(2): 644-51, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21195617
11.
Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation.
mBio
; 11(1)2020 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31992618
12.
In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.
PLoS Negl Trop Dis
; 14(1): e0007957, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31986143
13.
Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs.
ACS Infect Dis
; 6(2): 180-185, 2020 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31876143
14.
Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs.
ACS Infect Dis
; 6(2): 173-179, 2020 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31876154
15.
Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis.
Nat Commun
; 10(1): 2816, 2019 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31249291
16.
Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.
J Med Chem
; 62(5): 2521-2540, 2019 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30730745
17.
Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis.
EMBO Mol Med
; 9(3): 385-394, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28148555
18.
Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.
J Med Chem
; 60(13): 5889-5908, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28635296
19.
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.
Nat Commun
; 8: 14574, 2017 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28262680
20.
Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.
J Med Chem
; 58(13): 5344-54, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26067904