Detalhe da pesquisa
1.
The von Willebrand factor-binding aptamer rondaptivon pegol as a treatment for severe and nonsevere hemophilia A.
Blood
; 141(10): 1147-1158, 2023 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36108308
2.
The von Willebrand factor A-1 domain binding aptamer BT200 elevates plasma levels of von Willebrand factor and factor VIII: a first-in-human trial.
Haematologica
; 107(9): 2121-2132, 2022 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34818873
3.
Inhibition of complement C1s improves severe hemolytic anemia in cold agglutinin disease: a first-in-human trial.
Blood
; 133(9): 893-901, 2019 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30559259
4.
The VWF binding aptamer rondoraptivon pegol increases platelet counts and VWF/FVIII in type 2B von Willebrand disease.
Blood Adv
; 6(18): 5467-5476, 2022 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35772170
5.
Evidence of persistent neurologic injury following thrombotic thrombocytopenic purpura.
Am J Hematol
; 86(1): 87-9, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20981675
6.
The aptamer BT200 blocks von Willebrand factor and platelet function in blood of stroke patients.
Sci Rep
; 11(1): 3092, 2021 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33542410
7.
The aptamer ARC1779 blocks von Willebrand factor-dependent platelet function in patients with thrombotic thrombocytopenic purpura ex vivo.
Transfusion
; 50(5): 1079-87, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20070617
8.
Potent and rapid reversal of the von Willebrand factor inhibitor aptamer BT200.
J Thromb Haemost
; 18(7): 1695-1704, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32275107
9.
The aptamer BT200 effectively inhibits von Willebrand factor (VWF) dependent platelet function after stimulated VWF release by desmopressin or endotoxin.
Sci Rep
; 10(1): 11180, 2020 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32636459
10.
The development and characterization of a long acting anti-thrombotic von Willebrand factor (VWF) aptamer.
J Thromb Haemost
; 18(5): 1113-1123, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32011054
11.
von Willebrand Factor Predicts Mortality in ACS Patients Treated with Potent P2Y12 Antagonists and is Inhibited by Aptamer BT200 Ex Vivo.
Thromb Haemost
; 120(9): 1282-1290, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32679592
12.
Inhibition of complement C1s in patients with cold agglutinin disease: lessons learned from a named patient program.
Blood Adv
; 4(6): 997-1005, 2020 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32176765
13.
von Willebrand factor in cardiovascular disease: focus on acute coronary syndromes.
Circulation
; 117(11): 1449-59, 2008 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-18347221
14.
Anti-von Willebrand factor aptamer ARC1779 for refractory thrombotic thrombocytopenic purpura.
Transfusion
; 49(10): 2181-5, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19538431
15.
The aptamer ARC1779 is a potent and specific inhibitor of von Willebrand Factor mediated ex vivo platelet function in acute myocardial infarction.
Platelets
; 20(5): 334-40, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19637097
16.
Specific Inhibition of the Classical Complement Pathway Prevents C3 Deposition along the Dermal-Epidermal Junction in Bullous Pemphigoid.
J Invest Dermatol
; 139(12): 2417-2424.e2, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31229501
17.
First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers.
Circulation
; 116(23): 2678-86, 2007 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-18025536
18.
Pharmacokinetics, pharmacodynamics and safety of aptamers.
Adv Drug Deliv Rev
; 134: 36-50, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30321620
19.
Targeting von Willebrand Factor in Ischaemic Stroke: Focus on Clinical Evidence.
Thromb Haemost
; 118(6): 959-978, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29847840
20.
A Randomized, First-in-Human, Healthy Volunteer Trial of sutimlimab, a Humanized Antibody for the Specific Inhibition of the Classical Complement Pathway.
Clin Pharmacol Ther
; 104(4): 655-663, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29737533