Detalhe da pesquisa
1.
Synthesis of bis-thiohydantoin derivatives as an antiproliferative agents targeting EGFR inhibitory pathway.
Mol Divers
; 2023 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37306891
2.
New 1,3,4-oxadiazole-chalcone/benzimidazole hybrids as potent antiproliferative agents.
Arch Pharm (Weinheim)
; 356(2): e2200357, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36351754
3.
Discovery of new cyanopyridine/chalcone hybrids as dual inhibitors of EGFR/BRAFV600E with promising antiproliferative properties.
Arch Pharm (Weinheim)
; 356(4): e2200464, 2023 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-36526595
4.
Synthesis and Antiproliferative Potential of Thiazole and 4-Thiazolidinone Containing Motifs as Dual Inhibitors of EGFR and BRAFV600E.
Molecules
; 28(24)2023 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38138441
5.
Novel indazole derivatives as potent apoptotic antiproliferative agents by multi-targeted mechanism: Synthesis and biological evaluation.
Bioorg Chem
; 126: 105922, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35667253
6.
Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities.
Bioorg Chem
; 120: 105616, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35078049
7.
Discovery of new pyrimido[5,4-c]quinolines as potential antiproliferative agents with multitarget actions: Rapid synthesis, docking, and ADME studies.
Bioorg Chem
; 121: 105693, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35219045
8.
Mechanistic study of the antibacterial potential of the prenylated flavonoid auriculasin against Escherichia coli.
Arch Pharm (Weinheim)
; 355(12): e2200360, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36029269
9.
New 1,3,4-oxadiazoles linked with the 1,2,3-triazole moiety as antiproliferative agents targeting the EGFR tyrosine kinase.
Arch Pharm (Weinheim)
; 355(6): e2200009, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35195309
10.
New 1,2,4-oxadiazole/pyrrolidine hybrids as topoisomerase IV and DNA gyrase inhibitors with promising antibacterial activity.
Arch Pharm (Weinheim)
; 355(7): e2100516, 2022 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-35363388
11.
New pyrimidine/thiazole hybrids endowed with analgesic, anti-inflammatory, and lower cardiotoxic activities: Design, synthesis, and COX-2/sEH dual inhibition.
Arch Pharm (Weinheim)
; 355(7): e2200024, 2022 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-35429006
12.
Design, Synthesis and Biological Evaluation of Syn and Anti-like Double Warhead Quinolinones Bearing Dihydroxy Naphthalene Moiety as Epidermal Growth Factor Receptor Inhibitors with Potential Apoptotic Antiproliferative Action.
Molecules
; 27(24)2022 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36557897
13.
Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity.
Bioorg Chem
; 112: 104960, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34020242
14.
Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives bearing 1,3-thiazole moiety as novel anti-inflammatory EGFR inhibitors with cardiac safety profile.
Bioorg Chem
; 111: 104890, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33872924
15.
Design, synthesis, and antibacterial evaluation of new quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids as potential inhibitors of DNA gyrase and topoisomerase IV.
Bioorg Chem
; 112: 104920, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33910078
16.
Novel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects.
Bioorg Chem
; 116: 105302, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34464816
17.
Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease.
Bioorg Chem
; 116: 105363, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34555629
18.
Design and Synthesis of (2-oxo-1,2-Dihydroquinolin-4-yl)-1,2,3-triazole Derivatives via Click Reaction: Potential Apoptotic Antiproliferative Agents.
Molecules
; 26(22)2021 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34833890
19.
Cold-pressed raspberry seeds oil ameliorates high-fat diet triggered non-alcoholic fatty liver disease.
Saudi Pharm J
; 29(11): 1303-1313, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34819792
20.
Novel 1,2,4-triazole derivatives as apoptotic inducers targeting p53: Synthesis and antiproliferative activity.
Bioorg Chem
; 105: 104369, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33091670