Detalhe da pesquisa
1.
CSTI-300 (SMP-100); a Novel 5-HT3 Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome.
J Pharmacol Exp Ther
; 373(1): 122-134, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32102919
2.
From preclinical to clinical development: the example of a novel treatment for obesity.
Neurobiol Dis
; 61: 47-54, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23891728
3.
The discovery of diazepinone-based 5-HT3 receptor partial agonists.
Bioorg Med Chem Lett
; 24(11): 2578-81, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24755431
4.
The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties.
Bioorg Med Chem
; 22(13): 3414-22, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24842618
5.
Structural basis for partial agonism in 5-HT3A receptors.
Nat Struct Mol Biol
; 31(4): 598-609, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38177669
6.
Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1.
Bioorg Med Chem Lett
; 23(5): 1257-61, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23380375
7.
Epiminocyclohepta[b]indole analogs as 5-HT6 antagonists.
Bioorg Med Chem Lett
; 22(4): 1494-8, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22290076
8.
Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome.
Bioorg Med Chem Lett
; 21(1): 58-61, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21146988
9.
5-Functionalized indazoles as glucocorticoid receptor agonists.
Bioorg Med Chem Lett
; 20(10): 3017-20, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20427184
10.
5-(pyridinon-1-yl)indazoles and 5-(furopyridinon-5-yl)indazoles as MCH-1 antagonists.
Bioorg Med Chem Lett
; 20(23): 7015-9, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20961756
11.
Synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1H)ones as MCH-1 antagonists for the treatment of obesity.
Bioorg Med Chem Lett
; 20(23): 7020-3, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20951036
12.
Tetrahydrocarboline analogs as MCH-1 antagonists.
Bioorg Med Chem Lett
; 20(23): 7024-8, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20952195
13.
Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists.
Bioorg Med Chem Lett
; 20(9): 2785-9, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20371178
14.
Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.
Bioorg Med Chem Lett
; 20(9): 2912-5, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20347296
15.
Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists.
Bioorg Med Chem Lett
; 20(6): 1913-7, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20167483
16.
Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.
Bioorg Med Chem Lett
; 20(7): 2074-7, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20219372
17.
Author Correction: Structural basis for partial agonism in 5-HT3A receptors.
Nat Struct Mol Biol
; 31(4): 728, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38580848
18.
Bifidenone: Structure-Activity Relationship and Advanced Preclinical Candidate.
J Med Chem
; 61(15): 6736-6747, 2018 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29995409
19.
Inhibitors of Glycine Transporter-1: Potential Therapeutics for the Treatment of CNS Disorders.
Curr Top Med Chem
; 16(29): 3404-3437, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27048272
20.
Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1.
J Med Chem
; 59(18): 8473-94, 2016 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27559615