Detalhe da pesquisa
1.
Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer.
Mol Cancer Ther
; 21(6): 890-902, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35642432
2.
Benzimidazolone as potent chymase inhibitor: modulation of reactive metabolite formation in the hydrophobic (P1) region.
Bioorg Med Chem Lett
; 21(15): 4533-9, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21733690
3.
E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity.
ChemMedChem
; 16(11): 1740-1743, 2021 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33522135
4.
The discovery of thienopyridine analogues as potent IkappaB kinase beta inhibitors. Part II.
Bioorg Med Chem Lett
; 19(19): 5547-51, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19716697
5.
Estrogen Receptor Covalent Antagonists: The Best Is Yet to Come.
Cancer Res
; 79(8): 1740-1745, 2019 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30952631
6.
Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.
Nat Commun
; 10(1): 2527, 2019 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31164653
7.
RCM macrocyclization made practical: an efficient synthesis of HCV protease inhibitor BILN 2061.
Org Lett
; 10(6): 1303-6, 2008 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-18293994
8.
Synthesis and SAR studies of indole-based MK2 inhibitors.
Bioorg Med Chem Lett
; 18(6): 1994-9, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18291646
9.
Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variants.
Drug Metab Pharmacokinet
; 33(5): 219-227, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-30219715
10.
Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer.
Cancer Discov
; 8(9): 1176-1193, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29991605
11.
Discovery and optimization of p38 inhibitors via computer-assisted drug design.
J Med Chem
; 50(17): 4016-26, 2007 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-17658737
12.
H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma.
Cancer Res
; 77(24): 6999-7013, 2017 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29247039
13.
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.
Nat Commun
; 8(1): 103, 2017 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28740126
14.
Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).
J Med Chem
; 58(4): 1669-90, 2015 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25671290
15.
Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors.
J Med Chem
; 45(25): 5471-82, 2002 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12459015
16.
Total synthesis of 6-deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 cancer cell line.
Org Lett
; 16(21): 5560-3, 2014 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25376106
17.
Discovery of potent, selective chymase inhibitors via fragment linking strategies.
J Med Chem
; 56(11): 4465-81, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23659209
18.
Efficient chiral monophosphorus ligands for asymmetric Suzuki-Miyaura coupling reactions.
Org Lett
; 14(9): 2258-61, 2012 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22497425
19.
Torsion angle preference and energetics of small-molecule ligands bound to proteins.
J Chem Inf Model
; 47(6): 2242-52, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17880058
20.
Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors.
Bioorg Med Chem Lett
; 17(9): 2465-9, 2007 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17379516