Detalhe da pesquisa
1.
Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways.
J Neurosci
; 35(14): 5781-91, 2015 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25855188
2.
CCK Receptor Inhibition Reduces Pancreatic Tumor Fibrosis and Promotes Nanoparticle Delivery.
Biomedicines
; 12(5)2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38790986
3.
Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.
J Pharmacol Exp Ther
; 341(2): 396-409, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22328573
4.
Chronic suppression of phosphodiesterase 10A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in Huntington's disease.
J Pharmacol Exp Ther
; 336(1): 64-76, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20923867
5.
Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide.
Front Neurosci
; 13: 837, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31507355
6.
Behavioral characterization of mice deficient in the phosphodiesterase-10A (PDE10A) enzyme on a C57/Bl6N congenic background.
Neuropharmacology
; 54(2): 417-27, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18061215
7.
Vagotomy enhances experimental metastases of 4THMpc breast cancer cells and alters substance P level.
Regul Pept
; 151(1-3): 35-42, 2008 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-18499282
8.
Utilizing Peptide Ligand GPCRs to Image and Treat Pancreatic Cancer.
Biomedicines
; 6(2)2018 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29865257
9.
Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate.
J Med Chem
; 61(3): 1001-1018, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29293004
10.
Kinetics of metastatic breast cancer cell trafficking in bone.
Clin Cancer Res
; 12(5): 1431-40, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16533765
11.
Endogenous osteonectin/SPARC/BM-40 expression inhibits MDA-MB-231 breast cancer cell metastasis.
Cancer Res
; 65(16): 7370-7, 2005 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16103089
12.
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.
J Med Chem
; 60(13): 5673-5698, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28574706
13.
Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis.
Neuropharmacology
; 51(2): 386-96, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16780899
14.
Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington's Disease Models.
Neuron
; 92(6): 1220-1237, 2016 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27916455
15.
MDA-MB-435 human breast carcinoma metastasis to bone.
Clin Exp Metastasis
; 20(4): 327-34, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12856720
16.
KISS1 metastasis suppression and emergent pathways.
Clin Exp Metastasis
; 20(1): 11-8, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12650602
17.
Effects of alpha-difluoromethylornithine on local recurrence and pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude mice.
Clin Exp Metastasis
; 20(4): 321-5, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12856719
18.
A small molecule antagonist of the alpha(v)beta3 integrin suppresses MDA-MB-435 skeletal metastasis.
Clin Exp Metastasis
; 21(2): 119-28, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15168729
19.
Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.
J Med Chem
; 61(8): 3753, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29624389
20.
A single nucleotide polymorphism of the cholecystokinin-B receptor predicts risk for pancreatic cancer.
Cancer Biol Ther
; 13(3): 164-74, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22277584