Detalhe da pesquisa
1.
Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
Mol Cell
; 75(3): 483-497.e9, 2019 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31253574
2.
Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.
Nature
; 531(7596): 598-603, 2016 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-27029275
3.
MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans.
Blood
; 133(13): 1507-1516, 2019 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30692123
4.
Crystal structure of the human COP9 signalosome.
Nature
; 512(7513): 161-5, 2014 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25043011
5.
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.
Nature
; 512(7512): 49-53, 2014 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25043012
6.
Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.
Angew Chem Int Ed Engl
; 56(5): 1294-1297, 2017 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27981705
7.
Plasma contact system activation drives anaphylaxis in severe mast cell-mediated allergic reactions.
J Allergy Clin Immunol
; 135(4): 1031-1043.e6, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25240785
8.
Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV.
Bioorg Med Chem Lett
; 24(3): 731-6, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24439847
9.
A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target.
Proc Natl Acad Sci U S A
; 108(52): 21052-6, 2011 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22160684
10.
Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase.
ACS Med Chem Lett
; 14(12): 1631-1639, 2023 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38116426
11.
Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes.
Bioorg Med Chem Lett
; 22(3): 1464-8, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22177783
12.
The crystal structure of caspase-6, a selective effector of axonal degeneration.
Biochem J
; 423(3): 429-39, 2009 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19694615
13.
Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays.
Biochem J
; 420(1): 105-13, 2009 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-19207106
14.
Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.
J Med Chem
; 63(15): 8088-8113, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551603
15.
A fluorescence lifetime-based assay for protease inhibitor profiling on human kallikrein 7.
J Biomol Screen
; 14(1): 1-9, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19171917
16.
Targeting of the Cholecystokinin-2 Receptor with the Minigastrin Analog 177Lu-DOTA-PP-F11N: Does the Use of Protease Inhibitors Further Improve In Vivo Distribution?
J Nucl Med
; 60(3): 393-399, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30002107
17.
Structural basis of ubiquitin recognition by the deubiquitinating protease USP2.
Structure
; 14(8): 1293-302, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16905103
18.
The Intrinsic Pepsin Resistance of Interleukin-8 Can Be Explained from a Combined Bioinformatical and Experimental Approach.
IEEE/ACM Trans Comput Biol Bioinform
; 15(1): 300-308, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-28113517
19.
Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor.
J Mol Biol
; 355(2): 249-61, 2006 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-16305800
20.
Towards sensitive, high-throughput, biomolecular assays based on fluorescence lifetime.
Methods Appl Fluoresc
; 5(3): 034002, 2017 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28699919