Detalhe da pesquisa
1.
Modular Synthesis of Constrained Ethyl (cEt) Purine and Pyrimidine Nucleosides.
J Org Chem
; 80(10): 5337-43, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25894018
2.
Palladium-catalyzed synthesis of ammonium sulfinates from aryl halides and a sulfur dioxide surrogate: a gas- and reductant-free process.
Angew Chem Int Ed Engl
; 53(38): 10204-8, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25066222
3.
Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer.
Bioorg Med Chem Lett
; 23(7): 1945-8, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23466225
4.
Palladium-catalysed aminosulfonylation of aryl-, alkenyl- and heteroaryl halides: scope of the three-component synthesis of N-aminosulfonamides.
Org Biomol Chem
; 10(20): 4007-14, 2012 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22407213
5.
Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo.
Bioorg Med Chem Lett
; 19(23): 6670-4, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19854647
6.
Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable.
Bioorg Med Chem Lett
; 18(16): 4723-6, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18676144
7.
Palladium-catalyzed three-component diaryl sulfone synthesis exploiting the sulfur dioxide surrogate DABSO.
Angew Chem Int Ed Engl
; 52(48): 12679-83, 2013 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24115325
8.
Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
J Med Chem
; 58(20): 8128-40, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26407012
9.
Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: broad-spectrum antibacterial agents with reduced hERG activity.
J Med Chem
; 54(22): 7834-47, 2011 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21999508
10.
Glycosylated foldamers to probe the carbohydrate-carbohydrate interaction.
J Am Chem Soc
; 128(33): 10638-9, 2006 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-16910632
11.
Discovery, synthesis and biological evaluation of novel glucokinase activators.
Bioorg Med Chem Lett
; 15(8): 2103-6, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15808477
12.
Synthesis of cytidine ribonucleotides by stepwise assembly of the heterocycle on a sugar phosphate.
Chembiochem
; 4(6): 504-7, 2003 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12794860
13.
Enantioselective epoxidation of alkenes catalyzed by 2-fluoro-N-carbethoxytropinone and related tropinone derivatives.
J Org Chem
; 67(24): 8610-7, 2002 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-12444645