Efficient light couplers to topological slow light waveguides in valley photonic crystals.

We numerically and experimentally demonstrate efficient light couplers between topological slow light waveguides in valley photonic crystals (VPhCs) and wire waveguides. By numerical simulations, we obtained a high coupling efficiency of -0.84 dB/coupler on average in the slow light regime of a group index ng = 10 - 30. Experimentally, we fabricated the couplers in a Si slab and measured the transmitted power of the devices. We realized a high coupling efficiency of approximately -1.2 dB/coupler in the slow light region of ng = 10 - 30, which is close to the result from the numerical simulations. These demonstrations will lay the groundwork for low-loss photonic integrated circuits using topological slow light waveguides.

High-Q two-dimensional photonic crystal nanocavity on glass with an upper glass thin film.

We numerically analyze two-dimensional photonic crystal (PhC) nanocavities on glass with a thin glass film on top of the structure. We investigated a multistep heterostructure GaAs PhC nanocavity located on glass. We found that covering the structure even with a very thin glass film efficiently suppresses unwanted polarization mode conversion occurring due to the asymmetric refractive index environment around the PhC. We also uncovered that the glass-covered structure can exhibit a higher Q factor than that observed in the structure symmetrically cladded with thick glass. We point out that the mode mismatch between the PhC nanocavity and modes in the upper glass film largely contributed to the observed Q-factor enhancement. These observations were further analyzed through the comparison among different types of on-glass PhC nanocavities covered with thin glass films. We also discuss that the in-plane structure of the upper glass film is important for additionally enhancing the Q factor of the nanocavity.

Optimizing the optical and magneto-optical response of all-dielectric metasurfaces with tilted side walls.

All-dielectric metasurfaces based on ferrimagnetic iron garnets are a promising platform for realizing ultra-compact magneto-optical (MO) devices with low loss. However, ferrimagnetic iron garnets are notorious for being intractable on fine nanopatterning, hindering the faithful fabrication of designed nanostructures. In this regard, it is important to assess the influence of fabrication imperfections on the performance of MO metasurfaces. Here, we investigate the optical properties of a MO metasurface with structural imperfections. As the most typical fabrication error, we studied the impact of the tilted side walls of cylindrical garnet disks that constitute the metasurfaces. We found that tilting the side walls drastically degrades the MO response and light transmittance of the device. Nevertheless, it was also found that the performance can be recovered by optimizing the refractive index of the material covering the upper half of the nanodisks.

Transmission properties of microwaves at an optical Weyl point in a three-dimensional chiral photonic crystal.

Microwave transmission measurements were performed for a three-dimensional (3D) layer-by-layer chiral photonic crystal (PhC), whose photonic band structure contains 3D singular points, Weyl points. For the frequency and wavevector in the vicinity of a Weyl point, the transmitted intensity was found to be inversely proportional to the square of the propagation length. In addition, the transmitted wave was well-collimated in the plane parallel to the PhC layers, even for point-source incidence. When a plane wave was incident on the PhC containing metal scatters, the planar wavefront was reconstructed after the transmission, indicating a cloaking effect.

Experimental demonstration of topological slow light waveguides in valley photonic crystals.

We experimentally demonstrate topological slow light waveguides in valley photonic crystals (VPhCs). We employed a bearded interface formed between two topologically-distinct VPhCs patterned in an air-bridged silicon slab. The interface supports both topological and non-topological slow light modes below the light line. By means of optical microscopy, we observed light propagation in the topological mode in the slow light regime with a group index ng over 30. Furthermore, we confirmed light transmission via the slow light mode even under the presence of sharp waveguide bends. In comparison between the topological and non-topological modes, we found that the topological mode exhibits much more efficient waveguiding than the trivial one, demonstrating topological protection in the slow light regime. This work paves the way for exploring topological slow-light devices compatible with existing photonics technologies.

Unidirectional output from a quantum-dot single-photon source hybrid integrated on silicon.

We report a quantum-dot single-photon source (QD SPS) hybrid integrated on a silicon waveguide embedding a photonic crystal mirror, which reflects photons and enables efficient unidirectional output from the waveguide. The silicon waveguide is constituted of a subwavelength grating so as to maintain the high efficiency even under the presence of stacking misalignment accompanied by hybrid integration processes. Experimentally, we assembled the hybrid photonic structure by transfer printing and demonstrated single-photon generation from a QD and its unidirectional output from the waveguide. These results point out a promising approach toward scalable integration of SPSs on silicon quantum photonics platforms.

Slow light waveguides in topological valley photonic crystals.

Valley photonic crystals (VPhCs) are an attractive platform for the implementation of topologically protected optical waveguides in photonic integrated circuits (PICs). The realization of slow light modes in the topological waveguides may lead to further miniaturization and functionalization of the PICs. In this Letter, we report an approach to realize topological slow light waveguides in semiconductor-slab-based VPhCs. We show that a bearded interface of two topologically distinct VPhCs can support topological kink modes with large group indices over 100 within the topological bandgap. We numerically demonstrate robust light propagation in the topological slow light waveguide with large group indices of ∼60, even under the presence of sharp bends. Our work opens a novel route to implement topological slow light waveguides in a way compatible with current PIC technology.

Spin-dependent directional emission from a quantum dot ensemble embedded in an asymmetric waveguide.

In this study, we examine a photonic wire waveguide embedded with an ensemble of quantum dots (QDs) that directionally emits into the waveguide depending on the spin state of the ensemble. The directional emission is facilitated by the spin-orbit interaction of light. The waveguide has a two-step stair-like cross section and QDs are embedded only in the upper step, such that the circular polarization of emission from the spin-polarized QDs controls the direction of the radiation. We numerically verify that more than 70% of the radiation from the ensemble emitter is toward a specific direction in the waveguide. We also examine a microdisk resonator with a stair-like edge, which supports selective coupling of the QD ensemble radiation into a whispering gallery mode that rotates unidirectionally. Our study provides a foundation for spin-dependent optoelectronic devices.

Donor characteristics and risk factors for methicillin-resistant Staphylococcus aureus contamination in storage medium for corneal transplantation: A 10-year retrospective study.

PURPOSE: This study investigated the donor characteristics of methicillin-resistant Staphylococcus aureus (MRSA) contamination in storage medium before transfer of corneas to preservation medium for corneal transplantation, in order to identify donor characteristic risk factors for MRSA contamination. METHODS: This retrospective, cross-sectional study was performed using Juntendo Eye Bank records for all corneal transplantation procedures. Storage medium (EP-II® ) cultures for right eyes were included for the period between July 2008 and December 2017. The following donor characteristics were collected: age, sex, cause of death, history of cataract surgery, death-to-enucleation interval, death-to-preservation interval, and endothelial cell density (ECD). Donor characteristics were compared between MRSA and non-MRSA contamination groups. Odds ratios (ORs) for donor-related risk factors for MRSA contamination were determined using logistic regression. RESULTS: In total, 370 storage medium samples were examined; 222 were positive for bacterial cultures (60.0%) and 36 were MRSA-positive (9.7%). Donor age was significantly higher in the MRSA contamination group than in the non-MRSA contamination group (86.1 ± 9.5 years vs 75.9 ± 15.9 years, P < 0.001). Univariate logistic regression analysis showed that MRSA contamination risk factors were older age (OR = 1.07; 95% confidence interval [95% CI]: 1.03-1.11) and decreased ECD (OR = 0.9993; 95% CI: 0.9986-0.9992). The fully adjusted OR for every year of age as a risk factor for MRSA contamination was 1.07 (95% CI: 1.03-1.11). CONCLUSIONS: Aging was a risk factor for MRSA contamination in storage medium. Careful pre-banking assessment of elderly donor corneas is needed to prevent intractable postoperative MRSA infection.

Periostin deletion suppresses late-phase response in mouse experimental allergic conjunctivitis.

BACKGROUND: To investigate the potential roles of periostin (POSTN), an extracellular matrix preferentially expressed in Th2-skewed conditions in the pathophysiology of allergic conjunctivitis. METHODS: The roles of POSTN in ragweed-induced experimental allergic conjunctivitis (RW-EAC) were evaluated using both POSTN-knockout (KO) and congenic BALB/c wild-type mice. Histological analysis was carried out to enumerate eosinophils/basophils in the conjunctival tissue. Th2 cytokine expression was evaluated by quantitative polymerase chain reaction (Q-PCR), and microarray analysis was performed to elucidate genes differentially expressed in POSTN-KO and wild-type mice in the RW-EAC model. RESULTS: Upregulation of POSTN expression and eosinophil infiltration was observed in subconjunctival tissue of RW-EAC in the wild-type mice. The number of infiltrating eosinophils in the conjunctivae of RW-EAC was diminished in POSTN-KO mice compared to wild-type mice. Q-PCR analysis of conjunctival tissue showed induction of Th2 cytokine (Ccl5, Il4, Il5, Il13) expression in the RW-EAC and attenuated Ccl5, Il4, Il13 mRNA expression in the conjunctivae of the RW-EAC using POSTN-KO mice. Microarray analysis and immunohistochemical analysis showed diminished basophil marker (Mcpt8) expression and reduced numbers of infiltrating basophils in the conjunctivae of RW-EAC in POSTN-KO mice. CONCLUSIONS: POSTN expression in conjunctival tissue plays an indispensable role in the late-phase reaction of the RW-EAC model by facilitating eosinophil/basophil infiltration and augmenting Th2 cytokine expression.

Scheme for media conversion between electronic spin and photonic orbital angular momentum based on photonic nanocavity.

Light with nonzero orbital angular momentum (OAM) or twisted light is promising for quantum communication applications such as OAM-entangled photonic qubits. Methods and devices for the conversion of the photonic OAM to photonic spin angular momentum (SAM), as well as for the photonic SAM to electronic SAM transformation are known but the direct conversion between the photonic OAM and electronic SAM is not available within a single device. Here, we propose a scheme which converts photonic OAM to electronic SAM and vice versa within a single nanophotonic device. We employed a photonic crystal nanocavity with an embedded quantum dot (QD) which confines an electron spin as a stationary qubit. The confined spin-polarized electrons could recombine with holes to give circularly polarized emission, which could drive the rotation of the nanocavity modes via the strong optical spin-orbit interaction. The rotating modes then radiate light with nonzero OAM, allowing this device to serve as a transmitter. As this can be a unitary process, the time-reversed case enables the device to function as a receiver. This scheme could be generalized to other systems with a resonator and quantum emitters such as a microdisk and defects in diamond for example. Our scheme shows the potential for realizing an (ultra)compact electronic SAM-photonic OAM interface to accommodate OAM as an additional degree of freedom for quantum information purposes.

Thresholdless quantum dot nanolaser.

Thresholdless lasing is an outstanding challenge in laser science and is achievable only in devices having near unity quantum efficiency even when not lasing. Such lasers are expected to exhibit featureless linear light output curves. However, such thresholdless behavior hinders identification of the laser transition, triggering a long-lasting argument on how to identify the lasing. Here, we demonstrate thresholdless lasing in a semiconductor quantum dot nanolaser with a photonic crystal nanocavity. We employ cavity resonant excitation for enabling the thresholdless operation via focused carrier injection into high cavity field regions. Under conventional (above bandgap) excitation, the same nanolaser exhibits a typical thresholded lasing transition, thereby facilitating a systematic comparison between the thresholdless and thresholded laser transitions in the single device. Our approach enables a clear verification of the thresholdless lasing and reveals core elements for its realization using quantum dots, paving the way to the development of ultimately energy-efficient nanolasers.

A Nanowire-Based Plasmonic Quantum Dot Laser.

Quantum dots enable strong carrier confinement and exhibit a delta-function like density of states, offering significant improvements to laser performance and high-temperature stability when used as a gain medium. However, quantum dot lasers have been limited to photonic cavities that are diffraction-limited and further miniaturization to meet the demands of nanophotonic-electronic integration applications is challenging based on existing designs. Here we introduce the first quantum dot-based plasmonic laser to reduce the cross-sectional area of nanowire quantum dot lasers below the cutoff limit of photonic modes while maintaining the length in the order of the lasing wavelength. Metal organic chemical vapor deposition grown GaAs-AlGaAs core-shell nanowires containing InGaAs quantum dot stacks are placed directly on a silver film, and lasing was observed from single nanowires originating from the InGaAs quantum dot emission into the low-loss higher order plasmonic mode. Lasing threshold pump fluences as low as ∼120 µJ/cm(2) was observed at 7 K, and lasing was observed up to 125 K. Temperature stability from the quantum dot gain, leading to a high characteristic temperature was demonstrated. These results indicate that high-performance, miniaturized quantum dot lasers can be realized with plasmonics.

Escherichia coli-based production of recombinant ovine angiotensinogen and its characterization as a renin substrate.

BACKGROUND: Angiotensinogen (ANG) is a macromolecular precursor of angiotensin, which regulates blood pressure and electrolyte balance. ANG is specifically cleaved by renin, an aspartic protease, to initiate the angiotensin-processing cascade. Ovine ANG (oANG) from sheep plasma has been shown to be a better substrate for human renin, and it has been used in clinical renin assays. To expand the availability of oANG, we aimed to produce milligram levels of recombinant oANG using an Escherichia coli expression system. RESULTS: When recombinant oANG was expressed from a T7 promoter in various E. coli strains at 37 °C, it accumulated in the insoluble fraction. However, by expressing oANG at 37 °C from a tac promoter, which has weaker transcriptional activity than a T7 promoter, we significantly elevated the ratio of soluble to insoluble recombinant oANG. Using a novel culturing system and auto-induction culture medium, we purified tac-expressed recombinant oANG to homogeneity, with a yield of 4.0 mg per liter of culture. Based on size-exclusion gel filtration analysis and dynamic light scattering analysis, the resulting purified oANG is a monomer in solution. The circular dichroism spectrum of E. coli-expressed recombinant oANG was similar to that of oANG expressed in CHO cells. Differential scanning fluorimetry showed that both preparations undergo a two-state transition during thermal denaturation, and the melting temperatures of recombinant oANG expressed in E. coli and CHO cells were 49.4 ± 0.16 °C and 51.6 ± 0.19 °C, respectively. The K(m) values of both oANG preparations were similar; the k(cat) value of E. coli-expressed recombinant oANG was slightly higher than that of CHO-expressed oANG. CONCLUSIONS: Recombinant oANG expressed in E. coli functions as a human renin substrate. This study presents an E. coli-based system for the rapid production of milligram quantities of a human renin substrate, which will be useful for both fundamental and clinical studies on renin and hypertension.

Direct modulation of 1.3 µm quantum dot lasers on silicon at 60 °C.

We demonstrate direct modulation of an InAs/GaAs quantum dot (QD) laser on Si. A Fabry-Pérot QD laser was integrated on Si by an ultraviolet-activated direct bonding method, and a cavity was formed using cleaved facets without HR/AR coatings. The bonded laser was operated under continuous-wave pumping at room temperature with a threshold current of 41 mA and a maximum output power of 30 mW (single facet). Even with such a simple device structure and fabrication process, our bonded laser is directly modulated using a 10 Gbps non-return-to-zero signal with an extinction ratio of 1.9 dB at room temperature. Furthermore, 6 Gbps modulation with an extinction ratio of 4.5 dB is achieved at temperatures up to 60 °C without any current or voltage adjustment. These results of device performances indicate an encouraging demonstration on III-V QD lasers on Si for the applications of the photonic integrated circuits.

High quality-factor Si/SiO(2)-InP hybrid micropillar cavities with submicrometer diameter for 1.55-µm telecommunication band.

We theoretically demonstrate high quality(Q)-factor micropillar cavities at 1.55-µm wavelength based on Si/SiO(2)-InP hybrid structure. An adiabatic design in distributed Bragg reflectors (DBRs) improves Q-factor for upto 3 orders of magnitude, while reducing the diameter to sub-micrometer. A moderate Q-factor of ~3000 and a Purcell factor of ~200 are realized by only 2 taper segments and fewer conventional DBR pairs, enabling single photon generation at GHz rate. As the taper segment number is increased, Q-factor can be boosted to ~10(5)-10(6), enabling coherent exchange between the emitter and the optical mode at 1.55 µm, which is applicable in quantum information networks.

Asymmetric out-of-plane power distribution in a two-dimensional photonic crystal nanocavity.

Conventional air-bridge two-dimensional photonic crystal (2D-PhC) nanocavities emit light with an equal power distribution for upward and downward out-of-plane directions. Some applications, however, require concentration of the radiation in a preferred direction. In this Letter, we design a 2D-PhC nanocavity that radiates dominantly into one of the out-of-plane directions with a narrow far-field distribution. Our design is based on a conventional air-bridge L3 photonic crystal nanocavity. The asymmetric out-of-plane power distribution is achieved solely by adding periodic shallow holes on the slab surface, which also function as a second-order grating for the directional beaming.

Vacuum Rabi spectra of a single quantum emitter.

We report the observation of the vacuum Rabi splitting of a single quantum emitter by measuring its direct spontaneous emission into free space. We use a semiconductor quantum dot inside a photonic crystal nanocavity, in conjunction with an appropriate cavity design and filtering with a polarizer and an aperture, enabling the extraction of the inherently weak emitter's signal. The emitter's vacuum Rabi spectra exhibit clear differences from those measured by detecting the cavity photon leakage. Moreover, we observe an asymmetric vacuum Rabi spectrum induced by interference between the emitter and cavity detection channels. Our observations lay the groundwork for accessing various cavity quantum electrodynamics phenomena that manifest themselves only in the emitter's direct spontaneous emission.