Detalhe da pesquisa
1.
Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer.
Cell
; 175(5): 1244-1258.e26, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30454645
2.
Novel compounds that reverse the disease phenotype in Type 2 Gaucher disease patient-derived cells.
Bioorg Med Chem Lett
; 30(2): 126806, 2020 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31757667
3.
Ribosome-Templated Azide-Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry.
J Am Chem Soc
; 138(9): 3136-44, 2016 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26878192
4.
Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis.
Bioorg Med Chem Lett
; 26(4): 1260-4, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26810316
5.
State-dependent inhibition of BK channels by the opioid agonist loperamide.
J Gen Physiol
; 153(9)2021 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34357374
6.
Synthesis, Biological Evaluation, and Computational Analysis of Biaryl Side-Chain Analogs of Solithromycin.
ChemMedChem
; 16(21): 3368-3373, 2021 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34355515
7.
The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site.
Mol Pharmacol
; 78(4): 648-57, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20660086
8.
3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts.
Bioorg Med Chem Lett
; 20(10): 3129-33, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20409708
9.
The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine.
J Pharmacol Exp Ther
; 328(3): 921-30, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19088300
10.
Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors.
Bioorg Med Chem Lett
; 19(5): 1488-91, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19179073
11.
Discovery of GlyT1 inhibitors with improved pharmacokinetic properties.
Bioorg Med Chem Lett
; 19(5): 1492-5, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19181525
12.
Patient-Derived Phenotypic High-Throughput Assay to Identify Small Molecules Restoring Lysosomal Function in Tay-Sachs Disease.
SLAS Discov
; 24(3): 295-303, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30616450
13.
High-Throughput Ca2+ Flux Assay To Monitor Cyclic Nucleotide-Gated Channel Activity and Characterize Achromatopsia Mutant Channel Function.
ACS Chem Neurosci
; 10(8): 3662-3670, 2019 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31290651
14.
mTOR hyperactivity mediates lysosomal dysfunction in Gaucher's disease iPSC-neuronal cells.
Dis Model Mech
; 12(10)2019 10 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31519738
15.
Identification of Novel Inhibitors of DLK Palmitoylation and Signaling by High Content Screening.
Sci Rep
; 9(1): 3632, 2019 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30842471
16.
Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors.
Circulation
; 115(12): 1581-90, 2007 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-17353435
17.
Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice.
Physiol Behav
; 95(5): 668-76, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18930070
18.
Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI.
ACS Med Chem Lett
; 7(3): 312-7, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985321
19.
Dynamic mass redistribution analysis of endogenous ß-adrenergic receptor signaling in neonatal rat cardiac fibroblasts.
Pharmacol Res Perspect
; 2(1)2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24683488
20.
Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration.
Neuropharmacology
; 62(3): 1453-60, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21112344