Detalhe da pesquisa
1.
Discovery, optimization and biological activity evaluation of genipin derivatives as potential KRAS G12D inhibitors.
Bioorg Chem
; 148: 107460, 2024 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-38781668
2.
Moderation of mitochondrial respiration mitigates metabolic syndrome of aging.
Proc Natl Acad Sci U S A
; 117(18): 9840-9850, 2020 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32303655
3.
Biological evaluation of mitochondria targeting small molecules as potent anticancer drugs.
Bioorg Chem
; 114: 105055, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34144278
4.
Design, synthesis and biological evaluation of novel thiazole-derivatives as mitochondrial targeting inhibitors of cancer cells.
Bioorg Chem
; 114: 105015, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34139611
5.
Design, synthesis and antitumor activities of thiazole-containing mitochondrial targeting agents.
Bioorg Chem
; 115: 105271, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34426155
6.
Drug discovery approaches targeting the incretin pathway.
Bioorg Chem
; 99: 103810, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32325333
7.
Phosphatase activity of small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST).
J Biol Chem
; 293(43): 16851-16861, 2018 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30217818
8.
Discovery of 2-ethoxy-4-(methoxymethyl)benzamide derivatives as potent and selective PTP1B inhibitors.
Bioorg Chem
; 92: 103273, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31539748
9.
Identification of lipid-like salicylic acid-based derivatives as potent and membrane-permeable PTP1B inhibitors.
Bioorg Chem
; 93: 103296, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31585268
10.
Anti-diabetic potential of Pueraria lobata root extract through promoting insulin signaling by PTP1B inhibition.
Bioorg Chem
; 87: 12-15, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30852232
11.
Surrogating and redirection of pyrazolo[1,5-a]pyrimidin-7(4H)-one core, a novel class of potent and selective DPP-4 inhibitors.
Bioorg Med Chem
; 26(4): 903-912, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29373269
12.
Y-shaped bis-arylethenesulfonic acid esters: Potential potent and membrane permeable protein tyrosine phosphatase 1B inhibitors.
Bioorg Med Chem Lett
; 27(10): 2166-2170, 2017 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28372909
13.
Synthesis, biological evaluation and molecular docking analysis of 2-phenyl-benzofuran-3-carboxamide derivatives as potential inhibitors of Staphylococcus aureus Sortase A.
Bioorg Med Chem
; 25(4): 1341-1351, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28094221
14.
Synthesis, biological evaluation and molecular docking of 2-phenyl-benzo[d]oxazole-7-carboxamide derivatives as potential Staphylococcus aureus Sortase A inhibitors.
Bioorg Med Chem Lett
; 26(16): 4081-5, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27400889
15.
Design, synthesis, and biological evaluation of 2-substituted ethenesulfonic acid ester derivatives as selective PTP1B inhibitors.
Pharmazie
; 70(7): 446-51, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26373204
16.
Identification of 2-substituted ethenesulfonic acid ester derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatase 1B.
Pharmazie
; 70(12): 777-83, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26817274
17.
Synthesis, biological activity evaluation and mechanism analysis of new ganglioside GM3 derivatives as potential agents for nervous functional recovery.
Eur J Med Chem
; 266: 116108, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38218125
18.
Discovery of Sortase A covalent inhibitors with benzofuranene cyanide structures as potential antibacterial agents against Staphylococcus aureus.
Eur J Med Chem
; 229: 114032, 2022 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34954590
19.
Design, synthesis and neurite outgrowth activity of novel ganglioside GM1 derivatives by remodeling of the fatty acid moiety.
Eur J Med Chem
; 241: 114636, 2022 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35952400
20.
Plasmalogens Eliminate Aging-Associated Synaptic Defects and Microglia-Mediated Neuroinflammation in Mice.
Front Mol Biosci
; 9: 815320, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35281262